60 research outputs found
Jurodstvo i um kak protivopoložnye točki zrenija u A. Platonova
No full textGünther H. Jurodstvo i um kak protivopoložnye točki zrenija u A. Platonova. In: Hodel R, Locher JP, eds. Sprache und Erzählhaltung bei Andrej Platonov. Slavica Helvetica. Vol 58. Bern, Berlin, Frankfurt u.a.: Lang; 1998: 117-131
4-Toluene sulfonate methyl-monooxygenase from Comamonas testosteroni T-2: purification and some properties of the oxygenase component
No full textComamonas testosteroni T-2 synthesizes an inducible enzyme system that oxygenates 4-toluene sulfontate (TS) to 4-sulfobenzyl alcohol when grown in TS-salts medium. We purified this TS methyl-monooxygenase system (TSMOS) and found it to consist of two components. A monomeric, iron-sulfur flavoprotein (component B), which has been shown to act as a reductase in the 4-sulfobenzoate dioxygenase system of this organism (H. H. Locher, T. Leisinger, and A. M. Cook, Biochem. J. 274:833-842, 1991), carried electrons from NADH to component M, an oxygenase. This oxygenase had the UV-visible spectral characteristics of an iron-sulfur protein. Mrs of about 152,000 for the native oxygenase and of 43,000 under denaturing conditions indicated a homotri- or homotetrameric enzyme, whose N-terminal amino acids and amino acid composition were determined. The activity of the purified enzyme was enhanced about fivefold by the addition of Fe2+. In the presence of O2 and NADH, components B and M together catalyzed the stoichiometric transformation of TS or p-toluate to the corresponding alcohol. The reaction was confirmed as oxygenation of the methyl group by observation of an oxygen atom from 18O2 in carboxybenzyl alcohol. The substrate range of TSMOS included carboxylated analogs of TS (p- and m-toluates and 4-ethylbenzoate), whereas p-xylene, toluene, and p-cresol were not substrates. TSMOS also catalyzed demethylation; 4-methoxybenzoate was transformed to 4-hydroxybenzoate and formaldehyde.publishe
Biomimetic Total Synthesis and Antimicrobial Evaluation of Anachelin H
No full textThe first biomimetic total synthesis of the iron chelator anachelin H isolated from the cyanobacterium Anabaena cylindrica is reported. A first generation approach delivered one enantiomeric series of the polyketide fragment. Comparison of the 1H NMR data suggested the relative configuration of this anachelin fragment. The relative and absolute configuration of anachelin H was then established by total synthesis. A second generation approach involved the enzymatic conversion of N,N-dimethyltyramine to the anachelin chromophore. It was demonstrated that the enzyme tyrosinase is activated by the product during this reaction, the anachelin chromophore can serve as a tyrosinase activator. Anachelin H was evaluated against a panel of eleven bacterial and fungal pathogens, and moderate antibiotic activity (32 µg/mL) against Moraxella catarrhalis was found.LSYN
Methodus Loci Communis Theologici De Invocatione Religiosa
No full textQuam Juvante Deo Uno et Trino Sub Præsidio ... Johannis Wirtzii ... Publicæ [syzētḗseōs] instituende causa exhibet Sebastianus H[ö]ggerus Sangallensis ...Dedikation an Sebastian Schobinger, Christoph Bufler, David Cuntz, Christoph Hoffmann, Melchior Locher, Jacob Hoffmann, Bartholomäus Anhorn, Jacob Brüllisauer, Heinrich Fels und Johann Konrad Fels auf dem Titelbl. verso. Gedichte von Joh. Heinrich Wirz und Jacob Wiedenkeller auf Bl. B4r.Diss. Hohe Schule Zürich, 164
Biomimetic Total Synthesis and Antimicrobial Evaluation of Anachelin H
No full textThe first biomimetic total synthesis of the iron chelator anachelin H isolated from the cyanobacterium
Anabaena cylindrica is reported. A first generation approach delivered one enantiomeric series of the
polyketide fragment. Comparison of the 1H NMR data suggested the relative configuration of this anachelin
fragment. The relative and absolute configuration of anachelin H was then established by total synthesis.
A second generation approach involved the enzymatic conversion of N,N-dimethyltyramine to the anachelin
chromophore. It was demonstrated that the enzyme tyrosinase is activated by the product during this
reaction, the anachelin chromophore can serve as a tyrosinase activator. Anachelin H was evaluated
against a panel of eleven bacterial and fungal pathogens, and moderate antibiotic activity (32 μg/mL)
against Moraxella catarrhalis was found
The development of a reliable and valid scale to measure aesthetic pleasure in design
No full textThere is a lack of consistency regarding the scales used to measure aesthetic pleasure. They are often chosen ad hoc or derived from other research fields but never validated for design. Moreover, those scales often do not measure aesthetic pleasure in isolation, but instead include its determinants (e.g., novelty). Therefore, we developed a scale to measure aesthetic pleasure. We also included scales to measure determinants known to influence aesthetic pleasure for discriminant validity purposes. In the exploratory phase, we identified highly reliable items representative of aesthetic pleasure and its determinants across product categories. In the validation phase, we confirmed these findings across different countries (Australia, Netherlands). Apart from the theoretical contribution, this research has practical implications for guiding designers.Industrial DesignIndustrial Design Engineerin
Art History in the Nordic Countries
No full textArtiklen belyser kunsthistoriefagets udvikling i Danmark, Norge, Sverige og Finland siden midten af 1800-tallet og frem til i dag, hvorvisuel kultur-studier i stigende grad præger billedforskningen
Waserisches Helden-Lied : dem ... H. Hans Heinrich Wasern, Gerichtsherren zu Lufingen, den 28. tag Brachmonat ... MDCLII, durch die gutthähtige Fürsehung des Höchsten ... erwehlten Haubt und Burgermeistern der Statt Zürich
No full textZu billichen hochverdienten Ehren ... aufgesetzt; und bey fliegender Pressen gesungen: durch ... Georgen Müllern, Pfarrern zu TahlweilBogensignatur: A₆Die Sammlung wurde 1783 von Johann Leus Schwiegersohn, Dr. Georg Locher, der Stadtbibliothek geschenk
ChemInform Abstract: Biomimetic Total Synthesis and Antimicrobial Evaluation of Anachelin H.
No full text
- …
