2,082 research outputs found
Is there really a power shortage in clinical trials testing the "homocysteine hypothesis?".
No full textG.J. Hankey, J.W. Eikelboom, K. Loh, Q. Yi, J. Pizzi, M. Tang, S. Hickling, M. Le, C.J. M. Klijn, P. Dusitanond, F. van Bockxmeer, A. Gelavis, R. Baker and K. Jamrozi
Design of a new Faculty of Architecture - Investigation and design of Media Facades
No full textGraduation Project [G.J. Smit] for both Architecture & Building Technology. [architecture] : design of a new Faculty of Architecture [building technology] : investigation and design of Media FacadesStrategic Architectural Design DevelopmentArchitecture & Building TechnologyArchitectur
Watertovenaars: Delftse ideeën voor nog 200 jaar Rijkswaterstaat
No full textEen bundel artikelen met inspiratie voor Rijkswaterstaat voor de ontwikkeling in de volgende 200 jaar. Watertovenaar of tovenaarsleerling? (K. d'Angremond, P. Huisman en G.I. Schiereek) De oudste deltawerken: dammen en duikers uit het begin van de jaartelling (T. de Ridder) Een erfenis uit de Bataafse periode (W.M. de Jong) Wat eerst: wonen, water, wegen of welvaart? (T.M. de Jong) Een nieuwe rol voor de waterstaatsingenieur (F.M. Sanders) De terugkeer van de stedenbouwkundige discipline (V.J. Meyer Water (P. Huisman, K. d'Angremond en G.J. Schiereek) Dynamische buffers in autosnelwegen (D. Westland en P.H.L. Bovy) Op de automatische piloot door de Randstad? (R. van der Heijden, V. Marchau, E. Molin en K. van Wees) Niet bruggen bouwen, maar zelf brug zijn (B. Enserink, M.P.M. van der Ploeg, WAH. Thissen en G.J. de Vreede) Nederland als vervoersemplacement? (M.P.C. Weijnen, W.A.H. Thissen en E.F. ten Heuvelhof) Immobilisatie van gevaarlijk afval (Ch.F.Hendriks) Dubbel verduurzamen van wegconstructies (A.A.A. Molenaar) Innovatie van de geometrische infrastructuur (P.J.G.Teunissen) Radarhoogtemetingen en de (voorname) rol van Delft (M. Naeije) Een hoog(water)standje (T. Rientjes, C. van den Akker en P. van der Veer) Naar één beslismodel voor de veiligheid (J.K. Vrijling en J. Stoop) De betrouwbaarheid van dijken (A. Verruijt) Windgolven, een fascinerend fenomeen (L.H. Holthuijsen en J.A. Battjes) Mijn droom: het railvaartuig (B. Boon) Een waterfilm in plaats van wielen (A. van Beek) Uren worden minuten (E.A.H. Vollebregt, H. Jansen en M.R.T. Roest) Een kwestie van schuiven (R.Brouwer, A.Hof en J. Schuurmans) Energie door vergisting van slib (M.S.M. letten en M.C.M. van Loosdrecht) Nóg een poldermodel: hoge-sterkte beton (J.C. Walraven) Atollen voor de Noordzeekust (J. Kristinsson) Van maker naar regisseur (H.A.J. de Ridder
Is There Really a Power Shortage in Clinical Trials Testing the "Homocysteine Hypothesis?"
No full textSustainable Chemical Processes and Products. New Design Methodology and Design Tools
No full textThe current chemical industry is not sustainable, which leads to the fact that innovation of chemical processes and products is too often hazardous for society in general and the environment in particular. It really is a challenge to implement sustainability considerations in the design activities of chemical engineers. Therefore, the main question of this thesis is: how can a trained chemical engineer develop a conceptual design of a chemical process or a chemical product in such a way that the final result clearly contributes to sustainable development? This question is answered after a profound discussion about the current chemical engineering practice and its relation to the sustainability debate. This dissertation claims that sustainable development of chemical engineering practices requires a general design methodology accompanied by a set of design tools. Such a combination of methodology and tools does not exist in the chemical engineering field. The author developed a new design methodology and seven new design tools that enable the incorporation of sustainability issues into the design practice of the chemical engineering field. The application and validity of the methodology and its tools are shown in seven, mainly industrial, case studies.Applied Science
Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: A randomized substudy of the VITATOPS trial
No full textPublished online before print November 29, 2004Background and Purpose— Epidemiological and laboratory studies suggest that increasing concentrations of plasma homocysteine (total homocysteine [tHcy]) accelerate cardiovascular disease by promoting vascular inflammation, endothelial dysfunction, and hypercoagulability. Methods— We conducted a randomized controlled trial in 285 patients with recent transient ischemic attack or stroke to examine the effect of lowering tHcy with folic acid 2 mg, vitamin B12 0.5 mg, and vitamin B6 25 mg compared with placebo on laboratory markers of vascular inflammation, endothelial dysfunction, and hypercoagulability. Results— At 6 months after randomization, there was no significant difference in blood concentrations of markers of vascular inflammation (high-sensitivity C-reactive protein [P=0.32]; soluble CD40L [P=0.33]; IL-6 [P=0.77]), endothelial dysfunction (vascular cell adhesion molecule-1 [P=0.27]; intercellular adhesion molecule-1 [P=0.08]; von Willebrand factor [P=0.92]), and hypercoagulability (P-selectin [P=0.33]; prothrombin fragment 1 and 2 [P=0.81]; D-dimer [P=0.88]) among patients assigned vitamin therapy compared with placebo despite a 3.7-µmol/L (95% CI, 2.7 to 4.7) reduction in total homocysteine (tHcy). Conclusions— Lowering tHcy by 3.7 µmol/L with folic acid-based multivitamin therapy does not significantly reduce blood concentrations of the biomarkers of inflammation, endothelial dysfunction, or hypercoagulability measured in our study. The possible explanations for our findings are: (1) these biomarkers are not sensitive to the effects of lowering tHcy (eg, multiple risk factor interventions may be required); (2) elevated tHcy causes cardiovascular disease by mechanisms other than the biomarkers measured; or (3) elevated tHcy is a noncausal marker of increased vascular risk.P. Dusitanond, J.W. Eikelboom, G.J. Hankey, J. Thom, G. Gilmore, K. Loh, Q. Yi, C.J.M. Klijn, P. Langton, F.M. van Bockxmeer, R. Baker and K. Jamrozi
Author response
No full textMost motile bacteria sense and respond to their environment through a transmembrane chemoreceptor array whose structure and function have been well-studied, but many species also contain an additional cluster of chemoreceptors in their cytoplasm. Although the cytoplasmic cluster is essential for normal chemotaxis in some organisms, its structure and function remain unknown. Here we use electron cryotomography to image the cytoplasmic chemoreceptor
cluster in Rhodobacter sphaeroides and Vibrio cholerae. We show that just like transmembrane arrays, cytoplasmic clusters contain trimers-of-receptor-dimers organized in 12-nm hexagonal arrays. In contrast to transmembrane arrays, however, cytoplasmic clusters comprise two CheA/
CheW baseplates sandwiching two opposed receptor arrays. We further show that cytoplasmic fragments of normally transmembrane E. coli chemoreceptors form similar sandwiched structures in the presence of molecular crowding agents. Together these results suggest that the 12-nm
hexagonal architecture is fundamentally important and that sandwiching and crowding can replace the stabilizing effect of the membrane
Verslag omtrent den aanleg van stroomleidende dammen in de Zandkreek en Veergat: opgemaakt door den ingenieur van den Rjjksvvaterstaat G.J. van den Broek
No full textOnderzoek naar kribben om de erosie van de steile oevers van het Veerse gat en Zandkreek tegen te gaa
Verslag omtrent het gebruik van Indische en Australische houtsoorten, volgens door den Rijkswaterstaat verstrekte gegevens, bewerkt door den ingenieur van den Rijkswaterstaat G.J. van den Broek
No full text- …
