1,721,166 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Gene expression in the striatum of cynomolgus monkeys after chronic administration of cocaine and heroin
No full textCocaine and heroin cause impairment of neural plasticity in the brain including striatum. This study aimed to identify genes differentially expressed in the striatum of cynomolgus monkeys in response to cocaine and heroin. After chronic administration of cocaine and heroin in the monkeys, we performed large？scale transcriptome profiling in the striatum using RNA？Seq technology and analysed functional annotation. We found that 547 and 1238 transcripts were more than 1.5？fold up？ or down？regulated in cocaine？ and heroin？treated groups, respectively, compared to the control group, and 3432 transcripts exhibited differential expression between cocaine？ and heroin？treated groups. Functional annotation analysis indicated that genes associated with nervous system development (NAGLU, MOBP and TTL7) and stress granule disassembly (KIF5B and KLC1) were differentially expressed in the cocaine？treated group compared to the control group, whereas gene associated with neuron apoptotic process (ERBB3) was differentially expressed in the heroin？treated group. In addition, IPA network analysis indicated that genes (TRAF6 and TRAF3IP2) associated with inflammation were increased by the chronic administration of cocaine and heroin. These results provide insight into the correlated molecular mechanisms as well as the upregulation and down？regulation of genes in the striatum after chronic exposure to cocaine and heroin.
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
해양방사능 물질이동 모델링 고도화
No full text2011년 후쿠시마 제1 원자력발전소 방사능 유출사고 이후, 해양 내 방사성물질의 이동예측에 대한 연구가 진행되고 있다. 향후 발생할 수 있는 방사능 및 오염물질 유출사고에 대비하기 위해 한국해양과학기술원에서는 고해상도 3차원 해양 재분석자료 생산 및 라그랑지안 입자추적모델을 활용한 방사성물질 확산 예측 시스템 마련을 위한 기초연구를 수행하고 있다.
한국해양과학기술원에서는 고해상도(1/12°수평해상도) 북태평양 해양순환 모델을 개발하여 3차원 해양 재분석자료를 생산하고 모델의 성능 검증을 수행하였다. 이를 바탕으로 붕괴, 물과 부유퇴적물 사이의 흡착-탈착, 해저에서의 퇴적-재부유 과정을 고려하는 라그랑지안 입자추적모델을 활용한 방사성물질 확산 예측모델 시스템을 마련하였다. 또한, 다중입경 부유퇴적물 모델 개발, 해양방사능 모델의 병렬화, 부유퇴적물과의 흡탈착 프로세스를 포함하는 새로운 연직 1차원 모델 개발 등 해양방사능 거동모델의 고도화을 수행하여 모델의 예측 성능을 향상시켰다.
본 해양방사능 거동모델의 결과와 한국원자력연구원의 모델 결과를 조합하여 후쿠시마 오염수 방류의 영향에 대한 예측 결과를 도출하였다. 日측의 실시계획안의 삼중수소 농도(연간 배출량 22 TBq 이하로 방류)를 이용하여 시뮬레이션을 수행한 결과, 제주도 남측 우리나라 관할해역에 도달하는 트리튬은 10년 후 약 0.001 Bq/m3의 농도에 수렴하는 것으로 나타났다
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Age-related effects of heroin on gene expression in the hippocampus and striatum of cynomolgus monkeys
No full textObjective:
The aim of this study was to investigate differentially expressed genes and their functions in the hippocampus and striatum after heroin administration in cynomolgus macaques of different ages.
Methods:
Cynomolgus monkeys were divided by age as follows: 1 year (A1, n = 2); 3 to 4 years (A2, n = 2); 6 to 8 years (A3, n = 2); and older than 11 years (A4, n = 2). After heroin was injected intramuscularly into the monkeys (0.6 mg/kg), we performed large-scale transcriptome profiling in the hippocampus (H) and striatum (S) using RNA sequencing technology. Some genes were validated with real-time quantitative PCR.
Results:
In the hippocampus, the gene expression of A1H was similar to that of A4H, while the gene expression of A2H was similar to that of A3H. Genes associated with the mitogen-activated protein kinase signaling pathway (STMN1, FGF14, and MAPT) and γ-aminobutyric acid-ergic synapses (GABBR2 and GAD1) were differentially expressed among control and heroin-treated animals. Differential gene expression between A1S and A4S was the least significant, while differential gene expression between A3S and A2S was the most significant. Genes associated with the neurotrophin signaling pathway (NTRK1 and NGFR), autophagy (ATG5), and dopaminergic synapses (AKT1) in the striatum were differentially expressed among control and heroin-treated animals.
Conclusion:
These results suggest that even a single heroin exposure can cause differential gene expression in the hippocampus and striatum of nonhuman primates at different ages.
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
- …
