1,721,028 research outputs found
sj-pdf-1-imr-10.1177_03000605221122750 - Supplemental material for Evaluation of Motion Segment Size as a New Sensor-based Functional Outcome Measure in Stroke Rehabilitation
No full textSupplemental material, sj-pdf-1-imr-10.1177_03000605221122750 for Evaluation of Motion Segment Size as a New Sensor-based Functional Outcome Measure in Stroke Rehabilitation by Hyung Seok Nam, Woo Hyung Lee, Han Gil Seo, Matthew W. Smuck and Sungwan Kim in Journal of International Medical Research</p
sj-docx-1-nnr-10.1177_15459683231207354 – Supplemental material for A Systematic Review of the Learning Dynamics of Proprioception Training: Specificity, Acquisition, Retention, and Transfer
No full textSupplemental material, sj-docx-1-nnr-10.1177_15459683231207354 for A Systematic Review of the Learning Dynamics of Proprioception Training: Specificity, Acquisition, Retention, and Transfer by Han Gil Seo, Seo Jung Yun, Andria J. Farrens, Christopher A. Johnson and David J. Reinkensmeyer in Neurorehabilitation and Neural Repair</p
Data for: Effect of Dexmedetomidine Combined Anesthesia on Motor-Evoked Potentials during Brain Tumor Surgery
No full textThese data include de-identified clinical information and intraoperative neuromonitoring recordings of patients with brain tumor collected from one tertiary hospital. #LabelingDex0: Precedex -1: Precedex +Pre_hypesthesia0: hypesthesia(-)1: hypesthesia(+)resect_extent1: GTR: complete resection 2: NTR: <3-mm thin residual FLAIR around the rim of the resection cavity only3: STR: residual nodular fluid-attenuated inversion recovery signal abnormality4: BxRt/Lt/Midline1: Right2: Left3: Bothabruptno event: 0gradual: 1abrupt: 2Bilateral0: no event1: unilateral2: bilateralPathology_type1: meningioma2: glioblastoma3: glioma4: schuwanoma5: vascular malformation or hemangioma6. brain meta7. etcLesion location1: SupraT, Cortical2: SupraT, Subcortical3: SupraT (Cort + SubC)4: InfraT5: ExtensivePre_HCP0: HSP(-)1: HSP(+)MEP_Event1: No event2: Temporary deterioration <50%3: Temporary loss4: Persistent deterioration <50%5: Persistent lossM_Outcome1: No motor deterioration2: Transient deterioration (<1wk or discharge)3: Persistent deteriorationM_Prediction1: TP2: TN3: FP4: FNSEP_Event1: No event2: Temporary deterioration <50%3: Temporary loss4: Persistent deterioration <50%5: Persistent lossSEP_Event_type0: No event1: Bilateral2: UnilateralS_Outcome1: No sensory deterioration2: Transient deterioration (<1wk or discharge)3: Persistent deteriorationS_Prediction1: TP2: TN3: FP4: F
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
뇌졸중 백서 모델에서 지방유래 줄기세포 분비인자의 신경보호 및 신경재생 효과
Get PDF학위논문 (박사)-- 서울대학교 대학원 : 의과대학 의학과, 2018. 2. 백남종.Stem cell therapy is an emerging paradigm of stroke treatment. Recent evidence shows that stem cells exert their therapeutic effects through the secretion of immune modulatory, neurotrophic factors. Although potential neuroprotective and neuroregenerative mediators of stem cells have been previously suggested in both in vitro and in vivo studies, no study has compared their therapeutic effects with that of a whole stem cell secretome in an in vivo stroke model. Therefore, the objective of this study is to assess the neuroprotective and neuroregenerative effect of selected recombinant factors (RFs), detected in human adipose stem cell (hASC)-conditioned medium (CM), in a rat ischemic stroke model.
The CM was prepared by culturing human adipose stem cells for 72h in serum-free Dulbeccos modified Eagle medium (DMEM). Multi-protein analysis using multiplex bead array and ELISA were used to detect secreted factors in the CM. Ischemic stroke was induced in Sprague-Dawley rats using 2 h transient middle cerebral artery occlusion (MCAO). In experiment 1, the vehicle (DMEM), concentrated CM, and selected RFs mixed with DMEM were administered intracerebroventricularly to each group (n = 14, 15, and 16, respectively) at 1 hr after reperfusion. Rats were sacrificed 24 h after MCAO. In experiment 2, the appropriate treatment was injected intraventricularly 24 h after reperfusion (n = 5, 4, and 4, respectively). All animals received daily single intraperitoneal injections of bromodeoxyuridine (BrdU, 50 mg/kg) from day 1 to day 3. Then, all animals exercised on a rat treadmill during 2 weeks and were sacrificed 17 day after reperfusion.
IL-6, VEGF, HGF, and BDNF were detected in hASC-CM. In the experiment 1, the CM and RF groups both showed significantly better sensorimotor neurological test scores than the control group at 24 h post-MCAO. The infarct volume was significantly lower in both the CM and RF groups than in the control group. The number of TUNEL-positive apoptotic cells were reduced, whereas HSP70 expression was enhanced in the peri-infarct area in both the CM and RF groups. Moreover, hASC-CM and RFs reduced IκB phosphorylation and influenced bcl-2 and bax protein expression. In experiment 2, the RF group showed significantly better recovery of sensorimotor deficits at day 10, and increased neuronal proliferation in the perilesional area at day 17 after MCAO.
Our results suggest that RFs, selected from hASC-CM, may exert an immediate neuroprotective effect in an ischemic stroke rat model that is comparable to those effect of full hASC-CM. The therapeutic effects of the RFs may be mediated by an anti-inflammatory mechanism and cell apoptosis inhibition. In addition, the selected RFs may also exert a neuroregenerative effect when administered after acute phase of stroke . Hence, treatment with RFs can be considered a feasible substitute for stem cell therapy after stroke.1. Introduction 1
1.1. Stem cell therapy in stroke 1
1.2. Stem cell secretome and potential therapeutic mediators 2
1.3. Selected recombinant factors from stem cell secretome as a cell-free therapeutic agent in ischemic stroke 2
2. Materials and methods 4
2.1. Establishment of animal model and experimental design 4
2.2. Preparation and analysis of CM 8
2.3. Intraventricular injection 9
2.4. Behavioral tests 9
2.5. Infarct volume 10
2.6. Immunohistochemistry 11
2.7. TUNEL staining 13
2.8. Western blot 14
2.9. Statistical analysis 15
3. Results 16
2.1. Experiments 1 16
2.1.1. hASC-CM and RFs ameliorate neurologic deterioration after experimental stroke 16
2.2.2. hASC-CM and RFs reduce the infarct volume in the ischemic brain 20
2.2.3. hASC-CM and RFs reduce cell apoptosis and enhance HSP 70 expression in the lesion border zone 23
2.2.4. hASC-CM and RF reduce IκB phosphorylation and influence bcl-2 and box protein expression 28
2.2. Experiment 2 30
2.2.1. RFs improve the recovery of sensorimotor deficits 30
2.2.2. RFs increase the neuronal proliferation in the lesion border zone 33
4. Discussion 36
5. References 44
6. Appendix 51
7. 국문초록 52Docto
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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