83,610 research outputs found
Comparison of 90-day case-fatality after ischemic stroke between two different stroke outcome registries using propensity score matching analysis.
No full textYu K-H, Hong K-S, Lee B-C, Oh M-S, Cho Y-J, Koo J-S, Park J-M, Bae H-J, Han M-K, Ju Y-S, Kang D-W, Appelros P, Norrving B, Terent A. Comparison of 90-day case-fatality after ischemic stroke between two different stroke outcome registries using propensity score matching analysis. Acta Neurol Scand: 2011: 123: 325-331. © 2010 John Wiley & Sons A/S. Background - It has not been clarified whether the disparity in ischemic stroke outcome between populations is caused by ethnic and geographic differences or by variations in case mix. Propensity score matching (PSM) analysis can overcome some analytical problems but is rarely used in stroke outcome research. This study was to compare the ischemic stroke case-fatality between two PSM cohorts of Sweden and Korea. Methods - Prognostic variables related to baseline characteristics and stroke care were included in our PSM model. Then, we selected 7675 Swedish and 1220 Korean patients with ischemic stroke from each stroke registers and performed one-to-one matching based on propensity scores of each patient. Results - After PSM, all measured variables were well balanced in 1163 matched subjects, and the 90-day case-fatality was identical 6.2% (HR 0.997, 95%CI 0.905-1.099) in Sweden and Korea. Conclusions - No difference is found in the 90-day case-fatality in propensity score-matched Swedish and Korean patients with ischemic stroke
The Effects of Postannealing Treatment in Forming Gas on Low-k SiOC(H) Film
No full textThe effects of postannealing treatment in ambient forming gas (10% H(2):90%N(2)) on low-k SiOC(H) films deposited by plasma-enhanced chemical vapor deposition were investigated. The use of SiOC (H) films has certain advantages due to the presence of alkyl groups in the film, which result in improved hardness properties, compared with previously reported low-k materials. Metal-oxide-semiconductor capacitance-voltage measurements at 100 kHz indicated that the relative dielectric constant (k-value) of the as-grown film was approximately 2.4. When rapid thermal annealing (RTA) temperatures of up to 500 degrees C were used, the Si-O-C bonds were nearly maintained when the annealing was conducted using an ambient of forming gas, whereas they substantially decreased in an ambient of N(2) gas. The decrease in Si-O-C bond content results in an increase in k-value. In the film that underwent an RTA treatment at 600 degrees C, the alkyl groups of the film were released and the Si-O network was enhanced in both ambient gases, which has a critical effect on the change in k-value. (C) 2010 The Electrochemical Society. [DOI: 10.1149/1.3439670] All rights reserved.113sciescopu
Infrared matrix isolation study of acetone and methanol in solid argon
No full textThe infrared absorption spectra of acetone and methanol mixtures have been investigated in a solid argon matrix at 9 K. A number of intramolecular complex bands were observed both in the acetone and methanol fundamental regions. From the concentration dependence of the infrared spectral pattern, acetone and methanol seemed to form a 1:1 binary complex. Noticeable red-shifts of the C=O stretching mode of acetone as well as the O-H stretching mode of methanol suggest that the two molecules are bound mainly through a H-bond between the carbonyl oxygen and the hydroxyl hydrogen atoms. A relatively weaker H-bonded interaction appeared also to act between the oxygen atom of methanol and a hydrogen atom of acetone. This view was found to be consistent with ab initio SCF, MP2, and DFT level computations. The most stable structure calculated was found to possess those two kinds of H-bonds, assuming a planar six-membered ring-like structure
Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling
Get PDFThe Tcf/Lef family of transcription factors mediates the Wnt/��-catenin pathway that is involved in a wide range of biological processes, including vertebrate embryogenesis and diverse pathogenesis. Post-translational modifications, including phosphorylation, sumoylation and acetylation, are known to be important for the regulation of Tcf/Lef proteins. However, the importance of ubiquitination and ubiquitin-mediated regulatory mechanisms for Tcf/Lef activity are still unclear. Here, we newly show that ubiquitin C-terminal hydrolase 37 (Uch37), a deubiquitinase, interacts with Tcf7 (formerly named Tcf1) to activate Wnt signalling. Biochemical analyses demonstrated that deubiquitinating activity of Uch37 is not involved in Tcf7 protein stability but is required for the association of Tcf7 to target gene promoter in both Xenopus embryo and human liver cancer cells. In vivo analyses further revealed that Uch37 functions as a positive regulator of the Wnt/��-catenin pathway downstream of ��-catenin stabilization that is required for the expression of ventrolateral mesoderm genes during Xenopus gastrulation. Our study provides a new mechanism for chromatin occupancy of Tcf7 and uncovers the physiological significance of Uch37 during early vertebrate development by regulating the Wnt/��-catenin pathway. ? 2017 The Author(s).113Ysciescopu
3G-WLAN interworking: security analysis and new authentication and key agreement based on EAP-AKA
No full textThe 3rd Generation Partnership Project(3GPP) standard is developing System Architecture Evolution(SAE)/Long Term Evolution(LTE) architecture for the next generation mobile communication system. The SAE/LTE architecture provides secure service and 3G-WLAN interworking [9]. To provide secure 3G-WLAN interworking in the SAE/LTE architecture, Extensible Authentication Protocol-Authentication and Key Agreement(EAP-AKA) is used. However, EAP-AKA has several vulnerabilities such as disclosure of user identity, man-in-the-middle attack, Sequence Number(SQN) synchronization, and additional bandwidth consumption. Therefore, this paper analyzes threats and attacks in 3G-WLAN interworking and proposes a new authentication and key agreement protocol based on EAP-AKA. The proposed protocol combines Elliptic Curve Diffie-Hellman(ECDH) with symmetric key cryptosystem to overcome these vulnerabilities. Moreover, our protocol provides Perfect Forward Secrecy(PFS) to guarantee stronger security, mutual authentication, and resistance to replay attack. Compared with previous protocols which use public key cryptosystem with certificates, our protocol can reduce computational overhead
Cognitive responses to favor request from social targets of different relationships in a Confucian society
No full textMetastable Innershell Molecular State (MIMS) IV: Heteronucleus K-shell MIMS with H+ and He+
No full textAbstractThe model of MIMS (Metastable Innershell Molecular State) has been applied to interpreting the Kα X-ray satellite data of target atoms in H+ and He+ ion impact on Al, Ca and Ti targets. The binding energies of the heteronucleus H-K-MIMS (K-shell MIMS formed with H and a target atom) and He-K-MIMS have been obtained. The binding energy trend of the H-K-MIMS shows a Z2 dependency similar to that of the homonucleus K-MIMS, while that of the He-K-MIMS shows a transitional behavior from the former to the latter. These behaviors were interpreted with the Z-expansion theory of heteronucleus molecules
Drain current thermal noise modeling for deep submicron n- and p-channel MOSFETs
No full textThe drain current thermal noise has been measured and modeled for the short-channel devices fabricated with a standard 0.18 mum CMOS technology. We have derived a physics-based drain current thermal noise model for short-channel MOSFETs, which takes into account the velocity saturation effect and the carrier heating effect in gradual channel region. As a result, it is found that the well-known Q(inv)/L-2-formula, previously derived for long-channel, remains valid for even short-channel. The model excellently explained the carefully measured drain thermal noise for the entire V-GS and V-DS bias regions, not only in the n-channel, but also in the p-channel MOSFETs. Large excess noise, which was reported earlier in some other groups, was not observed in both the n-channel and the p-channel devices. (C) 2004 Elsevier Ltd. All rights reserved.This work was supported by the National Program
for Tera-level Nano Devices through the Ministry of Science
and Technology and by MICROS center through
the Korea Science and Engineering Foundation
Effects of Frequency Offset and Channel Estimation Error in Multicell Synchronous OFDM/CDMA Systems
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