405 research outputs found
Cultural Appropriation in Craig Thompson’s Graphic Novel Habibi
No full textAuthor: Safa Al-shammary University of Granada Download PDF version Craig Thompson’s Habibi (2011) is an American graphic novel based on a romantic fable that is set in an imaginary and modern Middle Eastern country. For the past century, the political turmoil in the Middle East has been caused to a large extent by Western geopolitical interests in the region (Ehteshami 2007, 123). The West, fueled by its power, has managed to control the East. Consequently, societies have evolved ways..
Monocentric Relationship Management (MRM) and Mcorebrain™: Defining the Single AI Paradigm Beyond CRM (Version 3.0)
Get PDFThis concept note introduces Monocentric Relationship Management (MRM) — an AI-native paradigm defining a single accountable AI controller that autonomously governs the entire relationship lifecycle beyond CRM.
Unlike traditional enterprise architectures that fragment intelligence across sales, marketing, pricing, contract management, credit decisioning, billing, entitlements, compliance, and service, MRM unifies them under one closed-loop cognitive system.
The framework integrates autonomy and governance through policy-as-code, human-in-the-loop oversight, and continuous learning. It reframes relationship management as an integrated control problem, where predictive and prescriptive intelligence operate within explicit safety, ethical, and compliance boundaries.
Version 3.0 expands the foundational model by introducing the Mcorebrain™ — the autonomous cognitive nucleus of MRM that interprets natural-language prompts, validates them against policy constraints, and autonomously constructs operational systems, including data models, logic, and user interfaces.
This release defines a prompt-driven generation model, connecting business intent, governance policy, and system execution in one unified, accountable framework.
Previous version:
Javanbakht, A.H. (2025). Monocentric Relationship Management: Defining the Single AI Paradigm Beyond CRM (v2.0). DOI: 10.5281/zenodo.17209903
License: Creative Commons Attribution 4.0 International (CC BY 4.0)
Author: Aydin Habibi Javanbakht — Berlin, Germany
DOI (this version): 10.5281/zenodo.1733476
Probiotics as Potential Tool to Mitigate Nucleotide Metabolism Alterations Induced by DiNP Dietary Exposure in Danio rerio
Get PDFDiisononyl phthalate, classified as endocrine disruptor, has been investigate to trigger lipid biosynthesis in both mammalian and teleostean animal models. Despite this, little is known about the effects of DiNP exposure at tolerable daily intake level and the possible mechanisms of its toxicity. Probiotics, on the other hand, were demonstrated to have beneficial effects on the organism’s metabolism and recently emerged as a possible tool to mitigate the EDC toxicity. In the present study, using a metabolomic approach, the potential hepatic sex-related toxicity of DiNP was investigated in adult zebrafish together with the mitigating action of the probiotic formulation SLAB51, which has already demonstrated its ability to ameliorate gastrointestinal pathologies in animals including humans. Zebrafish were exposed for 28 days to 50 µg/kg body weight (bw)/day of DiNP (DiNP) through their diet and treated with 109 CFU/g bw of SLAB51 (P) and the combination of DiNP and SLAB51 (DiNP + P), and the results were compared to those of an untreated control group (C). DiNP reduced AMP, IMP, and GMP in the purine metabolism, while such alterations were not observed in the DiNP + P group, for which the phenotype overlapped that of C fish. In addition, in male, DiNP reduced UMP and CMP levels in the pyrimidine metabolism, while the co-administration of probiotic shifted the DiNP + P metabolic phenotype toward that of P male and closed to C male, suggesting the beneficial effects of probiotics also in male fish. Overall, these results provide the first evidence of the disruptive actions of DiNP on hepatic nucleotide metabolism and mitigating action of the probiotic to reduce a DiNP-induced response in a sex-related manner
Correction to: A Randomized Clinical Trial of a Modified Mindfulness-Based Cognitive Therapy for Children Hospitalized with Cancer (Mindfulness, (2021), 12, 1, (141-151), 10.1007/s12671-020-01506-3)
Get PDFIn the original published version of this article, Dr. Randye J. Semple was captured as corresponding author instead of Dr. Mojtaba Habibi. Dr. Semple took the role of pre-publication correspondent simply because she is more familiar with the journal�s online submission process than Dr. Habibi. Thus, this erratum is presented to fix the error. The original article has been corrected. © 2020, Springer Science+Business Media, LLC, part of Springer Nature
Mitigation of PFOA-Induced Developmental Toxicity in Danio rerio by Bacillus subtilis var. natto: Focus on Growth and Ossification
Get PDFPerfluorooctanoic acid (PFOA) is a persistent environmental contaminant that resists biological degradation and accumulates in organisms. It disrupts zebrafish embryo development, affecting their heartbeat rate and locomotion. Meanwhile, probiotics are known to enhance the development and ossification of zebrafish embryos. In this study, we examined the toxic effects of PFOA on growth and bone formation in zebrafish and the potential of the probiotic Bacillus subtilis var. natto to counteract its toxicity. Larvae were exposed to 0, 50, or 100 mg/L PFOA from hatching to 21 days post-fertilization (dpf), with or without dietary probiotic supplementation (107 CFU/larva/day), and they were sampled at 7, 14, and 21 dpf. PFOA exposure reduced standard length at 21 dpf, while the co-administration of probiotics mitigated these effects. Craniofacial cartilage defects appeared in larvae exposed to 50 mg/L PFOA at 7 and 14 dpf, while 100 mg/L PFOA impaired bone development at 7 dpf. Probiotics counteracted these abnormalities. PFOA also delayed ossification, correlating with the downregulation of col10a1a, runx2b, and cyp26b1, while the probiotic treatment restored normal ossification. These findings improve our understanding of PFOA’s detrimental effects on zebrafish growth and bone formation while demonstrating the protective role of probiotics against PFOA-induced developmental toxicity
Corrigendum: Confirmatory factor analysis and gender invariance of the Persian version of psychological control scale: association with internalizing and externalizing behavior problems (Frontiers in Psychology, (2023), 14, (1128264), 10.3389/fpsyg.2023.1128264)
No full textCopyright © 2024 Habibi Asgarabad, Salehi Yegaei, Mokhtari, Izalnoo and Trejos-Castillo. cc-byIn the published article, there was an error in the correspondence details. As well as Pardis Salehi Yegaei, Mojtaba Habibi Asgarabad should also be listed as a corresponding author. The complete correspondence details are shown below: *Correspondence: Pardis Salehi Yegaei Mojtaba Habibi Asgarabad The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated
Seasonal Regulation and Functional Significance of GnIH in Goldfish
No full textGonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide named for its ability to inhibit gonadotropin (GTH) production in birds and mammals. Subsequently, variants of GnIH peptides have been discovered in different vertebrate species, including teleosts. In amphibians, GnIH was found to stimulate growth hormone (GH) release, suggesting a role in the regulation of somatic growth. These findings indicate that GnIH is an important component of the multifactorial control of reproduction and growth. However, information on physiological significance of GnIH is rather limited, and much less is known regarding the functions of these peptides in teleosts.
The main purpose of my thesis was to study the physiological role of goldfish GnIH (gGnIH) in the regulation of basal and native gonadotropin-releasing hormone-induced GTH and GH expression and secretion, in vivo and in vitro. The findings highlight the importance of seasonality and stage of gonadal recrudescence, and provide evidence for both direct and indirect actions of gGnIH, which resulted in both stimulation and inhibition of GTH and GH production. In goldfish, gGnIH can uncouple GTH and GH synthesis and release, as well as differentially regulate FSH- and LH-β mRNA expression in a seasonally-dependent manner. Additionally, the presence of gGnIH and gGnIH receptor (gGnIH-R) in the goldfish ovary and testis was the basis for studying its direct action on cultured gonads. Treatment with gGnIH altered the expression of genes involved in gonadal functions, providing a strong support for the hypothesis that gGnIH plays a role in the paracrine/autocrine regulation of gonadal functions in goldfish.
The findings in this thesis indicate that gGnIH plays a complex role in multifactorial control of growth and reproduction in goldfish, as compared to a dominant inhibitory role in the regulation of the gonadotropic axis as observed in higher vertebrates. Furthermore, the results presented provide novel information on the physiological functions of gGnIH in goldfish at the level of multiple target tissues, and provide a framework for understanding the role of gGnIH in the multifactorial control of reproduction and growth in teleosts
The Role of GnIH in Paracrine/Autocrine Control of Ovarian Function in Zebrafish (Danio rerio)
No full textGonadotropin inhibitory hormone (GnIH) is a hypothalamic neuropeptide, termed for its
observed inhibitory effect on the luteinizing hormone release from cultured pituitary of Japanese quail when it was first discovered in 2000. In vertebrates including fish, GnIH has been found in extra-hypothalamic tissues including gonads, however, information regarding the role of this peptide as extra-pituitary regulator of gonadal function is not available and require further research.
The goal of my thesis was to investigate direct action of GnIH, in vitro, on ovarian
steroidogenesis, final oocyte maturation, and gene expression using sexually mature zebrafish. In the present study, GnIH did not significantly affect transcript levels for genes involved in the control of gonadal function and steroid biosynthesis. However, GnIH significantly altered hCG-induced estradiol (E2) release and resumption of meiosis. Thus, the findings provide a support for the hypothesis that GnIH plays paracrine/autocrine role in the regulation of ovarian function in zebrafish
Disruption of metabolism in male goldfish (Carassius auratus) by environmental contaminants
No full textThere is increasing concern regarding the adverse effects of contaminants commonly found in the environment. Recent studies point to the endocrine disrupting effects of contaminants on fish in a number of Alberta Rivers. In the present thesis I utilized 1H-NMR metabolomics to study the effects of environmentally relevant concentrations of NP, DEHP, FS, BPA as well as mixture of these contaminants on metabolism of male goldfish. I demonstrated that these contaminants disrupt metabolism in organ-dependent and season-dependent manner. When present in mixture, these compounds disrupt metabolism differently from individual contaminants. Additionally, comparing the effects of contaminants with endogenous hormones (E2, T, T3) led me to conclude that contaminants with well documented endocrine disrupting ability exert a complex metabolic response in goldfish through multiple receptor mediated routes different from endogenous hormones
Habibi. Proposta di traduzione di un romanzo young adult
No full textThis dissertation intends to present and analyse the translation from English into Italian of the first twenty-five chapters of Habibi, a teenager and young adult’s novel written by the Palestinian-American author Naomi Shihab Nye. It has been necessary to present the theoretical approach to the literary translation studies, in order to focus the attention on the translation problems and provide suitable solutions and strategies.
The first chapter gives an historical perspective on children’s literature from the end of the Nineteenth century till today, distinguishing the Italian and the American contexts. The description of the evolution process of this literary genre, which developed to satisfy the needs of the educational system, is its central issue. At the end of the chapter, we outline the main traits characterizing children’s literature and the image of the ideal reader.
The second chapter provides an overview on Palestinian literature, especially on the features of the contemporary novel and the Diaspora literature. Afterwards, we present the author Naomi Shihab Nye and the book Habibi.
In the third chapter we analyze the novel, focusing the attention on the rhythm of the narration, on the linguistic registers and the textual peculiarities found during the reading stage, according to the features of the children’s literature.
The fourth chapter consists of the translation of the first twenty-five chapters of the novel.
The fifth chapter begins with a section about the translation theory, the literary translation studies, focusing on the translation of children’s literature. Finally, there is the translation analysis. Here we present the strategies and the choices of the translation process, along with some practical examples with reference to theoretical studies. Special attention is paid to culture-specific items, lexicon and syntax.The source text can be found in appendix
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