1,761 research outputs found
RIC-HSCT for MF/SS
No full textAdvanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS
Preparation of mono-sized epoxy/MF microcapsulesin the appearance of polyvinyl alcohol as co-emulsifier
No full textFor epoxy microcapsules embedded in concrete as mechanic-triggered self-healing adhesive, globular shape with uniform size is the basic requirement to ensure the solid shell broken and the liquid core released at a designed stress. In this paper, monodispersed melamine\u96formaldehyde (MF) resin-walled epoxy E-51 microcapsules were successfully fabricated in an in situ polycondensation process, in which a certain amount of polyvinyl alcohol (PVA) solution was added as coemulsifier to control the microcapsules\u92 shape and size. Detail investigation shows, with the cooperation of PVA, the microcapsule morphologies and size distribution were ease to be adjusted by the parameters such as emulsifying agents, agitation rate, pH value and acidification time
ACT Family Violence Intervention Program review
No full textThis paper reports on a review of the Australian Capital Territory’s Family Violence Intervention Program, which provides an interagency response to family violence matters.
The scope of the review was to analyse the program’s activities and outcomes using 2007–08 data provided by participating agencies, supported by in-depth interviews with key stakeholders including victims whose matters had been finalised in court. After the completion of this report, additional data from 2008–09 and 2009–10 was made available by some Family Violence Intervention Program (FVIP) participating agencies. Although not within the scope of this evaluation, these data pointed to some preliminary improvements in the FVIP
NF membrane fouling by aluminum and iron coagulant residuals after coagulation-MF pretreatment
No full textThe effects of coagulant residuals on fouling of a nanofiltration (NF) membrane were investigated. Experiments were carried out with a laboratory-scale microfiltration (MF)-NF setup and a pilot MF-NF plant. In the laboratory-scale experiments, NF feed water was pretreated with poly-aluminum chloride (PACl) or alum followed by MF. NF membrane permeability declined when the feed water contained residual aluminum at 18 μg/L or more, but not when it was lower than 9 μg/L. When pretreated with ferric chloride, no substantial decline of NF membrane permeability was observed: residual iron did not affect the permeability. When SiO2 was added to the water before the pretreatment with PACl, the NF membrane permeability declined at about double the speed. Thermodynamic calculations and elemental analysis of foulants recovered from the membranes indicated that the majority of inorganic foulants were compounds composed of aluminum, silicate, and possibly potassium. In the pilot plant, NF feed was pretreated by PACl. Transmembrane pressure for NF doubled over 4.5 months of operation. Although the aluminum concentration in the NF feed was not high (30 μg/L), analysis of membrane foulants revealed excessive accumulation of aluminum and silicate, also suggesting that aluminum residuals caused the membrane fouling by alumino-silicates or aluminum hydroxide
Influence of chemomechanical caries removal methods on dentine
No full textChemomechanical caries excavation is an excellent example of conservative caries removal methods due to its ability to reliably preserve a greater thickness of caries-affected dentine (CAD). Chemomechanical caries removal (CMCR) agents dissolve the denatured collagen fibrils leaving the sound and partially degraded fibrils intact. Also, one of the main advantages of the CMCR method is its characteristic visual excavation end point sign, after this point, the solution fails to become turbid. Chemomechanical caries removal agents are classified based on their chemistry into sodium hypochlorite (NaOCl)- or enzyme-based CMCR agents.
The aim of this project was to evaluate the efficacy of currently available chemomechanical caries removal methods and their effects on tooth substrate, residual bacteria, and bonding to dentine with either resin- or resin-modified glass ionomer (RM-GIC)-based adhesives. The current project was designed to answer five research questions. The first research question aimed to compare the caries excavation time between CMCR and rotary caries removal methods. According to the outcome of this study, the NaOCl-based CMCR method is more time consuming compared with the enzyme-based CMCR method. Furthermore, no significant difference in caries excavation time was found between the enzymebased CMCR and the caries-detector guided rotary caries excavation method.
The second research question investigated the effects of CMCR methods on surface topography, hardness and chemical structure of dentine. The morphological analysis showed that there was no smear layer formed following enzyme-based CMCR; while it was partially absent after the NaOCl-based CMCR method. Also, the Vickers hardness of residual dentine following both CMCR methods was lower than the hardness of dentine following the rotary caries removal method. Moreover, the outcome of this study also revealed that the CMCR methods investigated had no adverse effect on the chemical structure of dentine.
The third research question was regarding the evaluation of the antibacterial effects of CMCR agents. Accordingly, a study was conducted on coronal cariesfree dentine discs using a modified non-invasive protocol. This confocal laser scanning microscopy study reported that the enzyme-based CMCR agent (Papacarie) showed an antimicrobial effect similar to 2% chlorhexidine gluconate solution (gold standard antibacterial solution). The NaOCl-based CMCR agent (Carisolv) showed a weak antibacterial activity, which could be improved by subsequent application of a silver diamine fluoride and potassium iodide agent.
The ‘adhesion studies section’ of this project consists of three studies and was conducted to answer the fourth and fifth research questions of this project. The outcomes of the first and second studies showed that surface treatment of dentine with 37% phosphoric acid for 5 seconds had no adverse effect on bonding of RMGIC adhesives to both sound and caries-affected dentine, which addressed the fourth research question.
The purpose of the last research question was to evaluate the effect of CMCR method on bonding of MDP-containing self-etch and RM-GIC adhesives to residual caries-affected dentine. It was concluded that CMCR methods had no adverse effects on bonding to dentine and both adhesive systems showed good bond strengths to caries-affected dentine.published_or_final_versionDentistryDoctoralDoctor of Philosoph
Correction Factor on Dynamic Force in a Marsh Funnel Test for Tunneling
No full textThis paper presents an improvement on a previous model for predicting the Marsh funnel (MF) test that is used in slurry shield tunneling for evaluating the rheological properties of bentonite slurries. The improvement focuses on the prediction of the dynamic part for fluids with small MF times. The velocity profile of the Herschel-Bulkley fluid in a laminar pipe flow condition is first investigated and a correction factor is introduced in the improved model. Comparisons of results from experiments and calculations with the previous model confirm the improved performance over the existing model. The rheological parameters obtained from the improved model show good resemblance to those obtained from a laboratory viscometer. The work also provides a reference to similar applications such as fluid transportation through pipelines where dynamic pressure dominates and therefore should be correctly predicted considering its velocity profile in a laminar condition.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Offshore and Dredging Engineerin
New insights into the pathogenesis and therapy of Behçet's disease
No full textBehçet's disease is a chronic multisystem inflammatory disease characterized by the predominance of Th1 cytokines. The human leukocyte antigen-B 51 gene is associated with the disease in several ethnic groups, but it is not certain whether it is the susceptibility gene or if it is in linkage disequilibrium with other genes. Recent studies of polymorphisms of neighboring, as well as distant, genes to human leukocyte antigen-B 51 are helpful in elucidating the pathogenesis of the disease and could have therapeutic implications. © Elsevier Ltd. All rights reserved.AHRNAD T, 2003, ARTHRITIS RHEUM, V48, P807; AKTULGA E, 1980, HAEMATOLOGICA, V65, P399; Alpsoy E, 2002, ARCH DERMATOL, V138, P467, DOI 10.1001-archderm.138.4.467; Arayssi T, 2002, ARTHRITIS RHEUM, V46, pS181; BENAMOUR S, 1991, REV MED INTERNE, V12, P339, DOI 10.1016-S0248-8663(05)80843-4; BENEZRA D, 1988, TRANSPLANT P, V20, P136; Boiardi L, 2001, J RHEUMATOL, V28, P1283; Budak-Alpdogan T, 1998, BRIT J RHEUMATOL, V37, P1148; Calguneri M, 1996, DERMATOLOGY, V192, P125; Choukri F, 2001, HUM IMMUNOL, V62, P180, DOI 10.1016-S0198-8859(00)00249-4; Cohen R, 2002, ANN RHEUM DIS, V61, P157, DOI 10.1136-ard.61.2.157; DAVIES UM, 1988, BRIT J RHEUMATOL, V27, P300; Direskeneli H, 2001, ANN RHEUM DIS, V60, P996, DOI 10.1136-ard.60.11.996; Douglas JA, 2001, NAT GENET, V28, P361, DOI 10.1038-ng582; Goldstein DB, 2001, NAT GENET, V29, P109, DOI 10.1038-ng1001-109; Gonzalez-Escribano MF, 1998, TISSUE ANTIGENS, V52, P78; Gonzalez-Escribano MF, 1999, TISSUE ANTIGENS, V54, P278, DOI 10.1034-j.1399-0039.1999.540309.x; Gul A, 2002, GENES IMMUN, V3, P368, DOI 10.1038-sj.gene.6363863; Gul A, 2001, ARTHRITIS RHEUM, V44, P2693, DOI 10.1002-1529-0131(200111)44:112693::AID-ART4493.0.CO;2-M; Hamuryudan V, 1998, ANN INTERN MED, V128, P443; HAMURYUDAN V, 1991, BRIT J RHEUMATOL, V30, P395; SILMAN AJ, 1990, LANCET, V335, P1078; Karasneh J, 2003, RHEUMATOLOGY, V42, P860, DOI 10.1093-rheumatology-keg232; Kawano T, 1996, AM J GASTROENTEROL, V91, P309; Kimura T, 1998, HUM IMMUNOL, V59, P500, DOI 10.1016-S0198-8859(98)00047-0; Kotter I, 2001, TISSUE ANTIGENS, V58, P166, DOI 10.1034-j.1399-0039.2001.580304.x; Kotter I, 2003, BRIT J OPHTHALMOL, V87, P423, DOI 10.1136-bjo.87.4.423; Kram MT, 2003, DIS COLON RECTUM, V46, P118, DOI 10.1097-01.DCR.0000044733.59705.44; Lacomba MS, 2001, OPHTHALMIC RES, V33, P251; Lee EB, 2003, HUM IMMUNOL, V64, P614, DOI 10.1016-S0198-8859(03)00057-0; Licata G, 2003, ANN RHEUM DIS, V62, P280, DOI 10.1136-ard.62.3.280; MASUDA K, 1989, LANCET, V1, P1093; Melikoglu M, 2002, ARTHRITIS RHEUM, V46, pS206; Melikoglu M, 2002, ARTHRITIS RHEUM, V46, pS181; Mizuki N, 2001, HUM IMMUNOL, V62, P186, DOI 10.1016-S0198-8859(00)00246-9; Mizuki N, 2002, TISSUE ANTIGENS, V60, P396, DOI 10.1034-j.1399-0039.2002.600506.x; Mizuki N, 2000, INVEST OPHTH VIS SCI, V41, P3702; MORAL F, 1995, CLIN EXP RHEUMATOL, V13, P493; Muhl H, 2003, INT IMMUNOPHARMACOL, V3, P1247, DOI 10.1016-S1567-5769(03)00131-0; OHNO S, 1982, ARCH OPHTHALMOL-CHIC, V100, P1455; OZYAZGAN Y, 1992, BRIT J OPHTHALMOL, V76, P241, DOI 10.1136-bjo.76.4.241; Park SH, 2002, J KOREAN MED SCI, V17, P366; Renauld JC, 2003, NAT REV IMMUNOL, V3, P667, DOI 10.1038-nri1153; Robertson LP, 2001, RHEUMATOLOGY, V40, P473, DOI 10.1093-rheumatology-40.4.473; Sakane T, 1999, NEW ENGL J MED, V341, P1284, DOI 10.1056-NEJM199910213411707; Salvarani C, 2002, J RHEUMATOL, V29, P535; Salvarani C, 2001, J RHEUMATOL, V28, P1867; Sano K, 2001, TISSUE ANTIGENS, V58, P77, DOI 10.1034-j.1399-0039.2001.580202.x; Sfikakis PP, 2001, LANCET, V358, P295, DOI 10.1016-S0140-6736(01)05497-6; Vandenbroeck K, 2003, TRENDS PHARMACOL SCI, V24, P284, DOI 10.1016-S0165-6147(03)00131-7; Verity DH, 2000, EUR J IMMUNOGENET, V27, P73, DOI 10.1046-j.1365-2370.2000.00202.x; Witkin SS, 2002, CLIN INFECT DIS, V34, P204, DOI 10.1086-338261; Yabuki K, 1999, INVEST OPHTH VIS SCI, V40, P1921; YAZICI H, 1990, NEW ENGL J MED, V322, P281, DOI 10.1056-NEJM199002013220501; Yurdakul S, 2001, ARTHRITIS RHEUM, V44, P2686, DOI 10.1002-1529-0131(200111)44:112686::AID-ART4483.0.CO;2-H; Zierhut M, 2003, CELL MOL LIFE SCI, V60, P1903, DOI 10.1007-s00018-003-2333-339373
Thermal analysis of a miniature magnetic fluid seal installed in an implantable rotary pump
No full textThe capacity of a magnetic fluid (MF) seal is decreased by increased MF temperature. A cooling system for MF is limited in a miniature MF seal installed in an implantable rotary pump. MF temperature in an MF seal installed in an implantable rotary pump was studied. The temperature of MF in a rotary pump was measured in vitro. Also, steady-state thermal analyses were conducted for an implantable rotary pump model. The results showed that (1) the decrease in magnetization of an MF due to increased temperature is negligible when the heat transfer coefficient of the seal housing is greater than 500 W/(m2·K) and (2) the increased temperature is mainly due to heat flux from the motor, and the magnitude of temperature increase due to viscous friction in the MF is low. In conclusion, an MF seal can be used in an implantable rotary pump from the standpoint of heat characteristics
Magnetic fluid seals working in liquid environments: Factors limiting their life and solution methods
No full textA magnetic fluid (MF) seal enables mechanical contact-free rotation of a shaft and hence has excellent durability. The performance of an MF seal, however, decreases in liquids. Factors limiting seal life are MF flowing away and mixing of MF with liquids. We developed an MF seal that had a "shield'' mechanism. Two types of shield were placed in MF seals installed in rotary pumps. Long-term durability tests were conducted. The MF seal with a shield having a small cavity space showed a longer life (207+ days), while the MF seal with a shield having a large cavity space failed after 28, 32 and 31 days. When a rotary pump is connected to an afterload, water flows into the cavity space of the shield through a concentric annulus and compresses air in the cavity. The water flow stops once the air pressure equilibrates the afterload pressure. Water remained in the entrance annulus and did not make contact with the MF in the case of the shield having a small cavity space, while water entered the cavity space and made contact with the MF in the case of the shield having a large cavity space. Less water in contact with the MF prolonged the seal life. In conclusion, the use of an optimally designed shield prolongs an MF seal life by preventing the MF from flowing away and mixing with liquids
Evaluating the influence of different sit-to- stand strategies on the biomechanics of the upper extremity dependent on age and sex
No full textIntroduction: During the sit-to-stand (STS) motion, thigh push-of (TP) is frequently used, yet the biomechanical advantage for the upper extremity, is relatively unknown. In this thesis, the STS motion is analyzed for three different techniques; TP, armrest push-off (AP), and no arm aid (NA). The aim of this study is to determine the biomechanical advantage of the TP strategy through examining the joint moments (JM), and muscle forces (MF). Furthermore, the study aims to find whether age or gender affects the JM and MF generated in the TP, AP, and NA strategies. Method: Time to stand (TTS), JM and MF exerted on the upper extremity were examined for TP, AP and NA strategies for 34 participants across 3 groups: EM, elderly female (EF), and young males (YM). The metrics were obtained through inverse kinematic (IK), inverse dynamic (ID), and static optimization (SO) simulations in a 3D musculoskeletal model. Results: The time-to-stand (TTS) in elderly participants is significantly longer in the TP strategy than in the AP and NA strategies. For elderly people, the TP strategy results in upper extremity JM lower than during AP and equal as in NA. Similarly, the TP strategy results in significantly lower MF than the AP strategy, and equal MF as in the NA strategy. Conclusion: The TP strategy takes longer than AP and reduces the JM and MF for elderly participants. Moreover, the TP strategy does not yield higher JM and MF than the NA strategy for any participant group. Thus, the biomechanical advantage of the TP strategy for elderly people, are lowered JM and MF in the upper extremityBiomedical Engineerin
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