316 research outputs found
Sporadic imprinting defects in Prader-Willi-Syndrome and Angelman-Syndrome - implications for imprint-switch models, genetic counseling, and prenatal diagnosis
No full textKarin Buiting, Bärbel Dittrich, Stephanie Groß, Christina Lich, Claudia Färber, Tina Buchholz, Ellie Smith, André Reis, Joachim Bürger, Markus M. Nöthen, Ulli Barth-Witte, Bart Janssen, Dvorah Abeliovich, Israela Lerer, Ans M.W. van den Ouweland, Dicky J.J. Halley, Connie Schrander-Stumpel, Hubert Smeets, Peter Meinecke, Sue Malcolm, Anne Gardner, Marc Lalande, Robert D. Nicholls, Kathie Friend, Astrid Schulze, Gert Matthijs, Hannaleena Kokkonen, Pascale Hilbert, Lionel Van Maldergem, Guillermo Glover, Pablo Carbonell, Patrick Willems, Gabriele Gillessen-Kaesbach, Bernhard Horsthemk
MODEL PENYELESAIAN SENGKETA LINGKUNGAN HIDUP PABRIK KULIT PT. USAHA LOKA (Studi di Kelurahan Ciptomulyo Kecamatan Sukun Malang)
No full textDicky Adi Prasetya, Dr. Istislam, S.H., M.Hum, Lutfi Efendi, S.H, M.Hum Fakultas Hukum Universitas [email protected]  Abstrak Penelitian ini dititikberatkan pada permasalahan yang dilatarbelakangi oleh pencemaran sungai Badek di kelurahan Ciptomulyo Kecamatan Sukun Kota Malang oleh pabrik kulit PT. USAHA LOKA. Oleh karenanya penulis merumuskan model penyelesaian sengketa lingkungan hidup antara pabrik kulit PT. USAHA LOKA dengan masyarakat Ciptomulyo selama ini telah dilakukan dan faktor-faktor apa saja yang menghambat penyelesaian sengketa lingkungan hidup antara pabrik kulit PT. USAHA LOKA dengan masyarakat Ciptomulyo. Penelitian skripsi ini menggunakan metode yuridis empiris dengan metode pendekatan Yuridis Sosiologis. Lokasi penelitian yakni di Kelurahan Ciptomulyo. Kata Kunci: Penyelesaian Sengketa, Lingkungan Hidup. Abstract The research placed on problems that affected by the pollution of the river Badek Ciptomulyo Sub-district in kelurahan Breadfruit Malang by skin factory of PT. USAHA LOKA. Therefore the author to formulate a model of the environmental dispute resolution between the skin factory of PT. USAHA LOKA with the community Ciptomulyo as long as this has been done and what are the factors that inhibit the settlement of environmental disputes between the skin factory of PT. USAHA LOKA with community Ciptomulyo. This thesis research using an empirical juridical method with the Juridical Sociological approach method. The location of the research, which is in the village of Ciptomulyo. Keywords: Dispute Resolution, Environment. Â
Release and uptake of lysosomal enzymes : studied in cultured cells
No full textThe purpose of the experimental work described in this thesiswas to investigate some aspects of the release and uptake
of lysosomal enzymes. The experiments involved the use of
normal human and animal fibroblasts and some other cell
types such as hepatocytes and hepatoma cells as sources of
hydrolytic enzymes, and fibroblasts from patients with lysosomal
storage diseases associated with a single lysosomal
enzyme deficiency and with "1-cell" disease as recipient
cells. In a number of studies co-cultivation of normal and
mutant cells was applied. as a means to study the release
and uptake of lysosomal enzymes at physiological concentrations.
We have also studied some characteristics of released
lysosomal enzyme activities in· normal and mutant cell cultures
in comparison with the corresponding intracellular
activities. Finally, we have used somatic cell hybridization
to investigate the genetic background of the metabolic abnormalities
in some of the human mutant cells. Our studies
have provided information on the normal transport of lysosomal enzymes within the cell and between cells. Furthermore,
we hope that more knowledge about recognition and
uptake of lysosomal enzymes by deficient cells from patients
with lysosomal storage diseases will have future implications
for enzyme therapy
Ginnasio: Home furniture to support physical exercise
No full textThis graduation project is a demonstration of the potentialities of a theory-based approach to design for mood regulation, which is based on the belief that design can influence mood by enabling and stimulating people to engage in effective mood-regulating activities.For this project, the western home bathroom was chosen as a context of research, due to the personal interest of the author in the relaxing properties of bathing, and bathing related activities such as the Finnish sauna, and the Turkish steam bath.The goal of the project was kept very broad in the beginning and gradually narrowed down during the analysis phase. A significant contribution to the creation of a well-defined design goal was given by the realization that, while relaxing practices are usually well accommodated in the domestic environment, little attention is paid to activities that influence people’s mood towards a high energy state such as exercising. Eventually, the project’s objective became to design a piece of furniture, in which physical exercise-supporting features coexist with more relax-oriented attributes. This product would aim to make high energy state inducing activities an integral part of the everyday domestic routine.Three concepts were generated by following an incremental process in which insights from one idea served as a starting point for the next. The third and last concept was then developed using a broad variety of techniques such as sketching, collage making, digital visualization, prototyping, and testing.The final result is a piece of furniture to exercise and to relax on, which form stands somewhere in between a bench and a chaise longue. Its name is Ginnasio, a reference to the building that, in Ancient Greece, functioned as a training facility, but also as a place to relax, socialize and engage in philosophical discussion
ANALISIS PERBANDINGAN KEPEMIMPINAN DITINJAU DARI KARAKTERISTIK DAN PENGALAMAN ( STUDI KASUS DI MV.PAN GLOBAL)
No full textABSTRACT
Antonius Dicky Satriaji, 2017, 50134832 N "Comparison of leadership roles in terms of characteristics and experience (Case study in MV Pan Global)", Thesis of Nautical Study Program, Diploma IV Program, Merchant Marine Polytechnic Semarang, First Supervisor : Capt. H. Suherman, M.Mar, the Second Supervisor : Sri Purwantini, SE, S.Pd, MM
Leadership is important in an organization. Either profit organization or non profit. In all life a group needs a leader. To be a leader must go through various stages so as to be a good leader not born but made, the process of making someone a leader is called the science of leadership. Leadership can not be separated by discipline, because it is a very close relationship.
This thesis is an exposition, the research to explain and explain the object under study. The data used is data that has been collected at the time of the author carry out the practice screen for one year. The data obtained will be processed and arranged systematically and regularly.
In solving the problem, the authors argue that all officers on board must apply good leadership characteristics and instill discipline in them first. A good boss must also understand leadership based on management theory, and make experience as learning.
The frequent misunderstanding over the MV. Pan Global when ABK received orders from officers. This is due to the large number of officers who do not use the approach or give a firm assignment that causes saturation and even a rebellious nature of the order.
Finally the authors can draw the conclusions of the elements in the role of leadership on the ship are closely related to the success in achieving common goals.
Keywords: characteristic, officer, MV. Pan Globa
The jingling Geordie: community arts and the regional culture of the North East of England
No full textIn the light of the massive economic and social changes which have affected the North East of England over the last 25 years, the author assesses the vitality of the indigenous culture and reflects upon current cultural trends and the North East’s future, particularly in relation to a regional Europe. He traces the folk-tradition of the region and looks at ways in which this can be drawn upon to develop a meaningful link between past and present. He looks closely at the changing nature of class-relationships in the North East and reflects upon how a valid local culture can survive in a multi-cultural society. He draws upon his own extensive experience in Community Arts, looking at definitions of the term in the new political climate and arguing for its positive contribution to the cultural debate. He dwells on the issue of regionalism and devolution in a new Europe, comparing the situation in the North East of England with political and cultural changes in Scotland and other parts of the United Kingdom
Biochemical Characterisation of TSC1 and TSC2 Variants Identified in Patients with Tuberous Sclerosis Complex
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