211 research outputs found
A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles
No full textThe use of polymeric nanoparticles as drug delivery devices is becoming increasingly prevalent in a variety of therapeutic applications. Despite their widespread clinical use, the factors influencing the release profiles of nanoparticle-encapsulated drugs are still not quantitatively understood. We present here a new, semi-empirical model of drug release from polymeric nanoparticles using a formulation of dexamethasone encapsulated within poly(lactic-co-glycolic acid) to set model parameters. We introduce a three-dimensional voxel-based framework for Monte Carlo simulations that enables direct investigation of the entire spherical nanoparticle during particle degradation and drug release. Due to implementation of this model at the nanoscale, we utilize assumptions that simplify the model while still allowing multi-phase drug release to be simulated with good correlation to experimental results. In the future, emerging mechanistic understandings of nanoparticle drug release may be integrated into this simulation framework to increase predictive power.National Institutes of Health (U.S.) (GM57073
Toomas Pauli keerulised küsimused
No full textThe difficult questions of Toomas PaulToomas Paul, born in Tartu in 1939, is a prominent theologian,church historian, New Testament scholar and translator, as wellas an essayist, and a member of Academia Scientiarum et ArtiumEuropaea. He took part in the preparation of the Porvoo CommonStatement (1992) and attended the Lutheran-Orthodox Joint Commissionfor 12 years. Paul has published 19 books and countless articles,and still often gets press coverage concerning current problemsin different fields. He is deeply interested in science and culture andhas held a constant dialogue with physicists, neurologists, historiansand other professionals. His sermons, articles, conversations on theradio and TV have always interested different communities due tohis intellectual spirit, wittiness, honesty and broad mental horizon.At the same time, his chosen topics can be uneasy (data leaks, migration,prostitution, etc.), he is equally critical towards totalitarian andconsumer societies, while he even censures some church activities.Paul studied in Tallinn and worked at eight parish churches inthe countryside from 1960 to 1986. From then on he served at StJohn’s Church in the centre of Tallinn, and, since 1989, at SutlepaChapel on the premises of the Estonian Open Air Museum.Among other things, Paul’s connection to Tartu is that his teacherand collaborator Uku Masing (1909–1985), whose legacy he interpretsand publishes to this day in cooperation with Tartu scholars,resided there. Paul received his doctoral degree (1994, on the historyof Bible translation in Estonia) at the University of Tartu and hastaught at and been a member of the Religious Anthropology ProgramCommittee. Rector Volli Kalm, who presented Paul with the NationalThought Award on behalf of the University of Tartu, called Paul acustodian of basic values and stressed his importance in shaping socialmentality. Paul has been awarded many other prizes.In the article, I present biographical data and briefly characterizePaul as a reader and interpreter of theologians and philosophers likeMeister Eckhart or Spinoza, scientists and others, as well as an author. I am also publishing an unique questionnaire that he presentedto his audience already in the 1960s as a young cleric, and outline thedifficult questions about religion he has raised in his publications.I quote other authors and archival sources of the Consistory of theEstonian Evangelical Lutheran Church, adding passages from Paul’spersonal archives and our correspondence to show why he is highlyrecognised in both the religious and secular societies of Estonia
The Application for Visualizing Data Inquiries
No full textKäesoleva bakalaureusetöö kirjutamise käigus valmis andmepäringute visualiseerimise rakendus, mille loomisel kasutati Java 8 ning sellesse sisseehitatud lisateeke – JavaFX, Nashorn JavaScript Engine. Paremate kasutajaliidese komponentide lisamiseks kasutati ControlsFX teeki. Jõudlustestide täpsemaks hindamiseks kasutati vastavatesse rakendustesse sisse ehitatud ajamõõtmise funktsioone. Rakendus loodi ideega lihtsustada programmeerimisega igapäevaselt mitte tegelevate inimeste tööd andmete esmases analüüsis. Rakenduse eesmärk on pakkuda lõppkasutajale mugavat ja intuitiivse lähenemisega andmetöötlust. Rakendus on vabavaraline ning mõeldud kõigile kasutamiseks.The purpose of this Bachelors thesis is to develop a desktop application that helps to visualize data inquiries and provides an intuitive overview of data. The following technologies were used: Java 8, JavaFX, Nashorn JavaScript Engine and ControlsFX library for better user interface design. The application was created with the idea of simplifying the work of people without programming skills and statistical background. The main aim of the application was to provide the end user a convenient a toll for data queries. The application is freeware and publicly available
Methylmalonyl -Coa Decarboxylase (Ygfg) for Escherichia Coli: A New Activity for the Crotonase Superfamily
No full textThe E113Q mutant exhibited significantly larger isotope effect for both kcat and kcat/Km than wild-type, suggesting differences in reaction mechanism between wild type and E113Q. Although experimental difficulties encountered did not allow quantitative studies of stereochemistry of the MMDC reaction, the reaction catalyzed by wild-type MMDC proceeds with retention of configuration using (S)-methylmalonyl-CoA as a substrate, and with inversion of configuration using (R)-methylmalonyl-CoA as a substrate. H66F catalyzed the MMDC reaction with at least partial racemization. I postulated that His66 is important in retaining structure of the active site.Made available in DSpace on 2015-09-25T22:27:50Z (GMT). No. of bitstreams: 2
license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5)
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Previous issue date: 2001Embargo set by: Seth Robbins for item 86057
Lift date: Forever
Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDsRestricted to the U of I community idenfinitely during batch ingest of legacy ETDsU of I Only192 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001
Methylmalonyl -Coa Decarboxylase (Ygfg) for Escherichia Coli: A New Activity for the Crotonase Superfamily
No full text192 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001.The E113Q mutant exhibited significantly larger isotope effect for both kcat and kcat/Km than wild-type, suggesting differences in reaction mechanism between wild type and E113Q. Although experimental difficulties encountered did not allow quantitative studies of stereochemistry of the MMDC reaction, the reaction catalyzed by wild-type MMDC proceeds with retention of configuration using (S)-methylmalonyl-CoA as a substrate, and with inversion of configuration using (R)-methylmalonyl-CoA as a substrate. H66F catalyzed the MMDC reaction with at least partial racemization. I postulated that His66 is important in retaining structure of the active site.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD
Tartu ülikooli aeroionisatsiooni ja elektroaerosoolide laboratooriumi töötajad 16. aprillil 1970. a. Grupipilt
No full textPildistatud Tartu ülikooli aulasKaks veidi erinevat võtetI rida vasakult: 1. vaneminsener Lembit Sulbi, 2. tehnik Maret Murdvee, 3. tehnik Hillar Uibo, 4. üldfüüsika kateedri laborant Hilda Peegel, 5. üldfüüsika kateedri dotsent, laboratooriumi teaduslik juhendaja Jaan Reinet, 6. aspirant Lembit Visnapuu, 7. üldfüüsika kateedri vanemõpetaja Jaan Salm, 8. vaneminsener Reinhold Matisen
II rida vasakult: 1. insener Enn Üts, 2. noorem teaduslik töötaja Elmar Sula, 3. vanemlaborant Arp Raitmäe, 4. vaneminsener Toivo Madise, 5. vaneminsener Aleksander Jakobson, 6. noorem teaduslik töötaja Matti Fischer, 7. üldfüüsika kateedri tehnik Toomas Kleimann, 8. vaneminsener Aavo Hilpus
III rida vasakult: 1. insener Paul Väli, 2. noorem teaduslik töötaja Aadu Mirme, 3. laborant Kristjan Haller, 4. insener Tõnu Hiiemäe, 5. vaneminsener Elmar Jääger, 6. vaneminsener Herbert Kõlametshttps://www.ester.ee/record=b5689456*es
Optimization of parcel machine routes on the example of AS Eesti Post Tallinn courierpoint
No full textAntud lõputöös uuris autor tänast pakiautomaadi veoringide ülesehitust, saadetiste mahte ja veovahendite mahutavust Omniva Tallinna kullerpunkti näitel. Lõputöö eesmärk oli leida uue hanketsükli jaoks efektiivsed ja optimaalsed veoringid pakiautomaatide teenindamiseks.
Lõputöö teoreetilises osas anti ülevaade pakiautomaatide viimase miili logistika teoreetilisest poolest. Lisaks uuris autor veebipõhiste optimeerimistarkvarade näitel, kas ja millised tarkvarad on saadaval ilma takistava maksumüürita. Võimalikuks sobivaks tarkvaraks osutus autori valikul OptimoRoute rakendus, mille kohta tegi autor ka lühiülevaate.
Teises peatükis andis autor üldise ülevaate Omnivast ning tutvustas olemasolevat Omniva Tallinna kullerpunkti teenindatavat pakiautomaatide võrgustikku ja veoringide ülesehitust.
Lõputöö empiirilises osas leidis autor lahendused järgmistele uurimisküsimustele:
• milline on tänase pakimahu olukorras veoringide efektiivsus;
• millised on tuleviku hanketsükli jaoks optimaalsed pakiautomaadi veoringid;
• milline on potentsiaalne kokkuhoid või täiendav kulu koostööpartnerite kasutamisel võrreldes Omniva omatööjõu kasutamisega.
Lisaks proovis autor kasutada valitud OptimoRoute tarkvara püstitatud ülesande lahendamisel, kas ja kui hästi sobib antud tarkvara Omniva Tallinna kullerpunkti veoringide analüüsiks ja optimeerimiseks. Käesoleva ülesande lahendamisel leidis autor, et antud tarkvara kasutamine ei ole ilma täispaketti ostmata võimalik. Autori arvates ei ole selle ülesande lahendamiseks mõistlik antud tarkvara litsentsi soetada, kuna pakiautomaadi veoringide planeerimisel on tegemist kohtkindlate aadresspunktidega, mis on päevast päeva samad ning piisab ainult ühekordsest optimeerimisest.
Töö tulemusena leidis autor, et tänased olemasolevad pakiautomaatide veoringid vajavad muutmist, kuna veoringide pakimahud on liiga kõrged ja tööajad liiga pikad. Pärast uute veoringide moodustamist teostas autor kuluarvutused koostööpartnerite ja Omniva omatööjõu kasutamise kohta. Arvutuse tulemusel leidis autor, et koostööpartnerite kasutamine on soodsam kui omatööjõu kasutamine.In the thesis, the author studied the structure of parcel machine transport routes and the volume and quality of shipments on the example of Eesti Post AS, i.e. Omniva, Tallinn courier point. The aim of the thesis was to find efficient and optimal transport routes for servicing the parcel machines for the new procurement cycle.
In the theoretical part of the thesis, an overview was given on the theoretical background of the last mile logistics of parcel machines. In addition, on the example of web-based optimization software, the author investigated whether and which, if any, software is available to use without an impeding tax wall. The author chose the OptimoRoute application as a software most likely suitable for the analysis, of which a brief overview was given by the author.
In the second chapter, the author gave a general overview of Omniva and introduced the existing network of parcel machines serviced by Omniva Tallinn courier point as well as the structure of the existing transport routes.
In the empirical part of the thesis, the author found solutions to the following research questions:
• what is the efficiency of transport routes in the case of current package volumes;
• what are the optimal parcel machine routes for the upcoming procurement cycle;
• what are the potential savings or additional costs of using cooperation partners compared to using Omniva's own workforce.
In addition, the author attempted to use the previously selected OptimoRoute software for solving the set task of whether and how suitable the software is for the analysis and optimization of the routes of Omniva Tallinn courier point.
In the process of attempting to solve the task, the author discovered that using the software is not possible without purchasing the full package. Per author's opinion, it is not reasonable to acquire a license for the software in order to solve the task, as planning parcel machine routes is based on location-specific address points which remain unchanged on a day-to-day basis, due to which a one-time optimization is sufficient.
As a result of the thesis, the author found that the current routes for parcel machines should be changed, as the delivery volumes of the routes are too high and the working hours are too long. After the formation of new routes, the author performed cost calculations on the use of cooperation partners and Omniva's own workforce. As a result of the calculation, the author found that the use of cooperation partners is less expensive than the use of own workforce
Study of slope stability using analysis software on the example of the Kurepalu dam
No full textKäesolevas töös on uuritud nõlvapüsivuse modelleerimistarkvara Slide 6.0
kasutusvõimalusi ning leitud Kurepalu pinnaspaisu nõlvade nõlvapüsivustegurid
erinevates autori poolt programmiga loodud stsenaariumites.
Magistritöös on antud ülevaade pinnaspaisudest, nende ebastabiilseid olukordi
põhjustavatest teguritest ning Kurepalu pinnaspaisu konstruktiivsetest elementidest.
Labortingimustes on määratud kindlaks Kurepalu pinnaspaisu muldkeha
hüdrofüüsikalised ja füüsikalised omadused ning pinnase tugevusparameetrid, mida läks
vaja tõepäraste mudelite loomisel. Töös on antud ülevaade Slide 6.0 kasutusvõimalustest
ning autori poolt tarkvaraga loodud eriolukordadest, mis tekitasid loodud mudelite
paisudes ebastabiilsust.
Töö tulemusena on selgunud, et Kurepalu pinnaspaisu järgi konstrueeritud mudelid
saavutasid eritingimustes mitmel juhul nõlvapüsivuse varutegurite piirväärtused, kuigi
pinnaspaisu mudel, mis on kirjeldatud kõige täpsemalt olemasolevale olukorrale, püsis
igas olukorras stabiilsena.
Uuritud tarkvara rakendusvõimalused on laialdased ning võimaldavad antud tarkvara
kasutada edukalt hüdrotehniliste probleemide lahendamisel.The object of current thesis is to explore usage possibilities of the slope stability analysis
software Slide 6.0 and to discover the slope stability safety factors of the Kurepalu
embankment in conditions created by the Author.
In the Master's thesis the Author has given an overview about embankments, factors causing
the unstable situations and the structural elements of the Kurepalu embankment. In
laboratory conditions the soil’s hydraulic conductivity, physical properties and strength
parameters of the Kurepalu embankment were determined in order to create authentic
models with the modelling software. The author has given also an overview of the usage
possibilities of the Slide 6.0 and the overview of the special conditions created by the
Author with mentioned software that observed the embankment's model's factors of safety.
As a result of the current thesis, the Author discovered that the models, constructed on the
basis of the Kurepalu embankment, reached on several occasions the limit values of the
slope stability safety factors although the embankment model which was described most
accurately to the current situation stayed stable on every occasion.
The application possibilities of the researched software are impressive in the Author's
opinion and allow it to use the software successfully on finding solutions to certain
hydrotechnical engineering problems
Medi_Vizz: Tööriist meditsiiniliste andmete samaaegseks visualiseerimiseks
No full textDoctors must analyse the extensive amount of medical data before diagnosing a patient and
prescribing treatment. This is especially complicated for patients with multiple chronic
conditions, who can be treated by different specialists. The advent of electronic health records
granted doctors the opportunity to have all the available information at hand – on the computers
at their workstations. However, the challenge of representing these data in an easy-to understand way remained.
The Medi_Vizz application allows doctors to visualise individual
patients' diagnoses and laboratory analysis data. Medi_Vizz has a user-friendly interface and
creates comprehensible plots with medical data. Doctors can utilise these plots in clinical
decision support, while scientists can examine disease progression in individual patients,
making Medi_Vizz a valuable tool for both general healthcare and scientific research
Assessment of the suitability of the Estonian Health Record data for the prediction of ischemic stroke
No full textAn increase in the instances of cardiovascular diseases has elevated the need
for better and more efficient prediction models for ischemic stroke as well. Therefore, it
is vitally important to assess the Estonian Health Record laboratory data to find out its
suitability for ischemic stroke prediction models. To that effect five different approaches
and three methods were utilized in three tiers in this Thesis. The potential of binary
statement of measurement facts, as well as the actual analysis results, calculated z-scores
and medical reference values were evaluated as the input for prediction models. It was
found that the binary statement of measurements itself contained enough information for
a competitive prediction model. However, several analytes were identified that had
increased the quality of the prediction outcomes and therefore should be studied further
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