40,443 research outputs found
ASO Author Reflections: Presacral Neuroendocrine Neoplasms—Insights into a Rare Disease
No full textNo abstrac
1993-1994 T. R. Pearson
No full textT. R. Pearson, a.k.a. Rick Gavin, was born in Winston-Salem, North Carolina. He was a student at North Carolina State University, where he gained a B.A. and M.A. in English. He was the first recipient of the John and Renée Grisham Writer in Residence Fellowship. He is the acclaimed author of fourteen novels, including A Short History of a Small Place and Warwolf, and a dozen screenplays. Top of the Rock is his fifth nonfiction book. He lives in Virginia and Brooklyn, New York. (Photo credit: Marian Young)https://egrove.olemiss.edu/grisham_res/1026/thumbnail.jp
Presacral Neuroendocrine Neoplasms: A Multi-site Review of Surgical Outcomes
No full textIntroduction: Presacral neuroendocrine neoplasms (PNENs) are rare tumors, with limited data on management and outcomes. Methods: A retrospective review of institutional medical records was conducted to identify all patients with PNENs between 2008 and 2022. Data collection included demographics, symptoms, imaging, surgical approaches, pathology, complications, and long-term outcomes. Results: Twelve patients were identified; two-thirds were female, averaging 44.8 years of age, and, for the most part, presenting with back pain, constipation, and abdominal discomfort. Preoperative imaging included computed tomography scans and magnetic resonance images, with somatostatin receptor imaging and biopsies being common. Half of the patients had metastatic disease on presentation. Surgical approach varied, with anterior, posterior, and combined techniques used, often involving muscle transection and coccygectomy. Short-term complications affected one-quarter of patients. Pathologically, PNENs were mainly well-differentiated grade 2 tumors with positive synaptophysin and chromogranin A. Associated anomalies were common, with tail-gut cysts prevalent. Mean tumor diameter was 6.3 cm. Four patients received long-term adjuvant therapy. Disease progression necessitated additional interventions, including surgery and various chemotherapy regimens. Skeletal, liver, thyroid, lung, and pancreatic metastases occurred during follow-up, with no mortality reported. Kaplan–Meier analysis showed a 5-year local recurrence rate of 23.8%, disease progression rate of 14.3%, and de novo metastases rate of 30%. Conclusion: The study underscores the complex management of PNENs and emphasizes the need for multicenter research to better understand and manage these tumors. It provides valuable insights into surgical outcomes, recurrence rates, and overall survival, guiding future treatment strategies for PNEN patients
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Letter from J. R. Eakin to Carl Hayden
No full textLetter from J. R. Eakin to Carl T. Hayden concerning access to Rowe Well and the canyon
Letter from J. R. Eakin to Stephen Mather
No full textLetter from J. R. Eakin to Stephen T. Mather about expenses and reconstruction of the Kaibab Trail
Letter from Carl Hayden to J. R. Eakin
No full textLetter from Carl T. Hayden to J. R. Eakin regarding changes to the Grand Canyon National Park boundaries and the purchase of lands from William Randolph Hearst
Letter from F. R. Goodman to Carl Hayden
No full textLetter from F. R. Goodman to Carl T. Hayden asking for clarification about the agreement to construct an approach road to the par
Letter from Carl Hayden to F. R. Goodman
No full textLetter from Carl T. Hayden to F. R. Goodman concerning the purchase of Bright Angel Trail and construction of an approach road to the park
R-boundedness of smooth operator-valued functions
No full textIn this paper we study -boundedness of operator families \mathcal{T}\subset \calL(X,Y), where and are Banach spaces. Under cotype and type assumptions on and we give sufficient conditions for -boundedness. In the first part we show that certain integral operator are -bounded. This will be used to obtain -boundedness in the case that is the range of an operator-valued function T:\R^d\to \calL(X,Y) which is in a certain Besov space B^{d/r}_{r,1}(\R^d;\calL(X,Y)). The results will be applied to obtain -boundedness of semigroups and evolution families, and to obtain sufficient conditions for existence of solutions for stochastic Cauchy problems.Electrical Engineering, Mathematics and Computer Scienc
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