46,149 research outputs found
Supplemental_Info_for_HIgh-Throughput_CAR-T_Cytotoxicity_Assay_by_Martinez_et_al – Supplemental material for High-Throughput Flow Cytometric Method for the Simultaneous Measurement of CAR-T Cell Characterization and Cytotoxicity against Solid Tumor Cell Lines
No full textSupplemental material, Supplemental_Info_for_HIgh-Throughput_CAR-T_Cytotoxicity_Assay_by_Martinez_et_al for High-Throughput Flow Cytometric Method for the Simultaneous Measurement of CAR-T Cell Characterization and Cytotoxicity against Solid Tumor Cell Lines by Emily M. Martinez, Samuel D. Klebanoff, Stephanie Secrest, Gabrielle Romain, Samuel T. Haile, Peter C. R. Emtage and Amy E. Gilbert in SLAS Discovery</p
Settling of finite-size particles in isotropically forced, homogeneous turbulence: interface-resolved simulations
No full textWe have simulated the gravity-induced settling of finite-size particles in a turbulent background flow which is forced in a statistically-stationary fashion. The simulations are accurately resolving the solid-fluid interface with the aid of an immersed boundary technique [1]. The parameters of the simulation are (apart from background turbulence) identical to those of reference [2], where particle clustering was observed at a Galileo number of 178 and a solid volume fraction of 0.005. In the present case, it is found that a relative turbulence intensity of 0.24 leads to the disappearance of the clusters; as a consequence, the increase in average particle settling velocity found in [2] also vanishes. [1] M. Uhlmann. An immersed boundary method with direct forcing for the simulation of particulate flows. J. Comput. Phys., 209(2):448–476, 2005. [2] M. Uhlmann and T. Doychev. Sedimentation of a dilute suspension of rigid spheres at intermediate Galileo numbers: the effect of clustering upon the particle motion. J. Fluid Mech., 752:310–348, 2014
A critical analysis of Ethiopian Civil Code: in light of the core features of Continental European Codification
No full textThis dissertation examines the core features of codification and applies them to the Ethiopian civil code in order to critically analyze whether that code complies with the core features of continental European codification or not. The author describes the development of the system of law in Ethiopia - explaining how Ethiopia became one of Africa’s states highly influenced by the model of continental European codification, particularly with the introduction during the regime of Emperor Haile Sellasie (between 1957 and 1965) of a group of highly complex codes – Civil code, Civil Procedure code, Penal code, Criminal Procedure code, Commercial code and Maritime code – giving Ethiopia one of the most modern legal systems in the World
Mesophilic-hydrothermal-thermophilic (M-H-T) digestion of green corn straw
No full textMesophilic-hydrothermal (80-160 degrees C, 30 min)-thermophilic (M-H-T) digestion and control tests of mesophilic (M), thermophilic (T), hydrothermal-mesophilic (H-M), and mesophilic-thermophilic digestion (M-T) of green corn straw were conducted for a 20-day fermentation period. The results indicate that M-H-T is an efficient method to improve methane production. A maximum methane yield of 371.74 mL/g volatile solid was obtained by the M (3 days)-H (140 degrees C)-T (17 days) process, which was 20.44%, 16.55%, 31.44%, and 14.31% higher than the yields of the M, T, 140-M, and M-T processes. The enhanced methane production was attributed to (1) the improved hemicellulose degradation and lignin disorganization; (2) prevention of the degradation of soluble sugar, easily hydrolyzed hemicellulose and cellulose into furfural and methylfurfural; and (3) lack of formation of Maillard reaction products during initial hydrothermal treatment. (C) 2015 Elsevier Ltd. All rights reserved
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
The use of plant water relations to characterize tree species and sites in the drylands of northern Ethiopia
No full textWater relations of four tree species were studied in four sites in the drylands of northern Ethiopia. Predawn water potentials were significantly higher at all sites as compared to midday measurements for Acacia etbaica and Boswellia papyrifera. In contrast, Lannea fruticosa revealed this significant difference only once, while Terminalia brownii at only two of the four sites. An analysis of variance showed that A. etbaica has a wider tolerance range as compared to the other species. There was no significant difference among the four sites in terms of predawn, midday and diurnal ranges of water potential. The study revealed that A. etbaica and B. papyrifera are performing better as compared to T brownii and L. fruticosa under the current climatic conditions. Understanding the physiological basis of survival, productivity, ability to cope with low moisture availability, and growth potential of indigenous species in the drylands is essential for the utilization and promotion of these and other species. (C) 2004 Elsevier Ltd. All rights reserved
The maternal immune system during pregnancy and its influence on fetal development
No full textThe maternal immune system plays a critical role in the establishment, maintenance, and completion of a healthy pregnancy. However, the specific mechanisms utilized to achieve these goals are not well understood. Various cells and molecules of the immune system are key players in the development and function of the placenta and the fetus. Effector cells of the immune system act to promote and yet limit placental development. The T helper 1 (Th1)/T helper 2 (Th2) immune shift during pregnancy is well established. A fine balance between proinflammatory and anti-inflammatory influences is required. We herein review the evidence regarding maternal tolerance of fetal tissues and the underlying cell-mediated immune and humoral (hormones and cytokines) mechanisms. We also note the many unanswered questions in our understanding of these mechanisms. In addition, we summarize the clinical manifestations of an altered maternal immune system during pregnancy related to susceptibility to common viral, bacterial, and parasitic infections, as well as to autoimmune diseases.Peer reviewe
Erosie door open taludbekledingen. Samenvattend verslag + Bijlage A t/m D
No full textOpen taludbekledingen die bestaan uit in verband geplaatste betonblokken met gaten, bieden de mogelijkheid vegetatie te doen groeien, waardoor mogelijk een milieuvriendelijke oever kan worden verkregen. In het pioniersstadium van de vegetatie is het evenwel ongewenst dat de gatvulling uitspoelt. Teneinde de relatie tussen waterbeweging en erosie van de gatvulling vast te stellen, is door de Dienst Weg- en Waterbouwkunde van Rijkswaterstaat per brief d.d. 16 maart 1987 (kenmerk WB 570), opdracht verleend aan het Waterloopkundig Laboratorium tot het uitvoeren van onderzoek naar de erosie door open taludbekledingen. Het doel van het onderzoek is het ontwikkelen van ontwerprichtlijnen voor taludbekledingen met gaten die groter zijn dan de zand- of filterkorrels eronder. Hiertoe dient de kritieke waterbeweging bij een oever- of dijkbekleding te worden vastgesteld, waarbij nog toelaatbare erosie is te verwachten. De toelaatbare erosie mag daarbij maximaal gelijk zijn aan de hoeveelheid sediment in de gaten. Filter- of basismateriaal gelegen onder de elementen mag dus niet uitspoelen. Bij oeverbekledingen waar vegetatie een rol moet gaan spelen, is de toelaatbare erosie kleiner, dat wil zeggen in de gaten dient sediment achter te blijven.Steenzettingen - TAW/EN
Model Based Building Chilled Water Loop Delta-T Fault Diagnosis
No full textImproving chilled water delta-T, which is the temperature difference of chilled water supply and return temperature, in campus buildings that are connected to a central distribution loop will not only improve the power consumption of the building through reduced tertiary (building) pumping power but the impact on the central distribution system and chiller efficiencies will be even greater. A degraded delta-T is almost inevitable and it can be expected to fall to about one-half to two-thirds of design at low loads (Taylor, 2002) due to various causes, such as air entering and leaving temperatures, chilled water supply temperature, type and effectiveness of flow control valves, tertiary connection configuration types and operation, coil cooling loads, air economizers, etc. However, in most variable-flow chilled water with 2-way control valve systems, the root cause of low delta-T is at coil side (Zhang, 2012), for example the geometric configuration of coil. This paper firstly discusses chilled water coil heat exchanger model results to help define methods for detecting opportunities for improved delta-T when analyzing campus building systems for performance optimization measures. Meanwhile, the author developed an effectiveness-NTU cooling coil models for a case study building containing chilled water coils with a range of design configurations to study cooling coil delta-T characteristics under various conditions in order to diagnose the low delta-T imposed on the chilled water distribution loop by the building's chilled water system under various loading conditions. The results show model-based building chilled water Loop delta-T fault diagnosis is an effective way to evaluate existing building chilled water loop delta-T performance and identify avoidable or resoluble causes for improving chilled water loop delta-T
C3H7NO2S effect on concrete steel-rebar corrosion in 0.5 M H2SO4 simulating industrial/microbial environment
No full textThis paper investigates C3H7NO2S (Cysteine) effect on the inhibition of reinforcing steel corrosion in concrete immersed in 0.5 M H2SO4, for simulating industrial/microbial environment. Different C3H7NO2S concentrations were admixed, in duplicates, in steel-reinforced concrete samples that were partially immersed in the acidic sulphate environment. Electrochemical monitoring techniques of open circuit potential, as per ASTM C876-91 R99, and corrosion rate, by linear polarization resistance, were then employed for studying anticorrosion effect in steel-reinforced concrete samples by the organic hydrocarbon admixture. Analyses of electrochemical test-data followed ASTM G16-95 R04 prescriptions including probability distribution modeling with significant testing by Kolmogorov-Smirnov and student's t-tests statistics. Results established that all datasets of corrosion potential distributed like the Normal, the Gumbel and the Weibull distributions but that only the Weibull model described all the corrosion rate datasets in the study, as per the Kolmogorov-Smirnov test-statistics. Results of the student's t-test showed that differences of corrosion test-data between duplicated samples with the same C3H7NO2S concentrations were not statistically significant. These results indicated that 0.06878 M C3H7NO2S exhibited optimal inhibition efficiency η = 90.52±1.29% on reinforcing steel corrosion in the concrete samples immersed in 0.5 M H2SO4, simulating industrial/microbial service-environment
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