101,800 research outputs found
Letter from Gabe Hackman to W. T. Johnson
No full textLetter from Gabe Hackman to W. T. Johnson, giving him information for radio program
Allodia (Allodia) tuomikoskii Hackman 1971
No full text<i>*</i> <i>Allodia</i> (<i>Allodia</i>) <i>tuomikoskii</i> Hackman, 1971 <p> <i>Allodia (Allodia) tuomikoskii</i> Hackman, 1971: 3</p> <p> Specimen determined as <i>Mycetophila ornaticollis</i> Meigen, 1818 in the "Insecta Lapponica" collection.</p> <p> <b>Material.</b> Male [SPM­005131, without coloured tag, labelled: <i>M. ornaticollis</i> 6.8. Tärna] – Sweden: LY, Tärna, 6 August 1821.</p> <p> Undetermined specimen standing next to previous specimen. <b>Material.</b> Male [SPM­005132, without coloured tag, labelled: ď. Tärna] – Sweden:</p> <p>LY, Tärna, 1821.</p>Published as part of <i>Kjaerandsen, Jostein, 2005, A review of fungus gnats in the tribe Exechiini (Diptera, Mycetophilidae) from the J. W. Zetterstedt collection at the Museum of Zoology in Lund, Sweden, pp. 1-35 in Zootaxa 856</i> on page 13, DOI: <a href="http://zenodo.org/record/170744">10.5281/zenodo.170744</a>
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Measuring industry-science links through inventor-author relations: A profiling method
No full textIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
Wave turbulence of a rotating array of quantized vortices in the T → 0 temperature limit
No full textThe dynamics of quantized vortices in the zero temperature limit is currently of great interest, particularly in the case of the Fermi superfluid He-B. Here we study wave turbulence, generated by the librating motion of a rotating cylindrical container filled with He-B, in the limit of vanishing viscous forces at temperatures . The polarization of the quantized vortices with respect to the axis of rotation is measured using non-invasive NMR techniques. We observe a decrease of the polarization when the librating motion is started, and a two-stage relaxation process when the modulation of the rotation velocity is stopped. The first relaxation process is associated with the dissipation of large-scale flow stored in inertial waves and the solid body rotation of the vortex array. From the decay of these energy reservoirs we determine the rate of energy dissipation of large-scale flow. The later second process is related to the relaxation of Kelvin waves on individual vortices. This process is monitored by the recovery of the polarization. The existence of a Kelvin wave cascade at the lowest temperatures is currently a central open question. We supply some evidence for the cascade
HPRT mutational spectra and microsatellite DNA instability in HNPCC and lung cancer patients
No full textThe, general aims of this work have been to explore the use of microsatellite DNA length variation and mutational spectra of the hypoxanthine guanine phosphoribosyltransferase (HPRT) locus in T-cells as tools for a better understanding of human somatic mutagenesis in vivo. In particular (a) how inherited mismatch repair (MMR) deficiency may affect the stability of microsatellite DNA and the mutational spectrum at the HPRT locus, and (b) how the mutational spectrum at the HPRT locus is influenced by smoking, and by predisposition to lung cancer among never smokers. Microsatellite DNA length variation (MSDLV) was studied in DNA from T-cell clones and peripheral blood lymphocytes, using suitable markers for PCR analysis and polyacrylamide gel electrophoresis. T-cell cloning in medium containing 6-thioguanine was used to select for HPRT mutant clones, and the mutations were further classified and characterised by PCR-based methods and DNA sequencing.The background frequency of MSDLV in peripheral lymphocytes was determined using three microsatellite markers (D2S123, D9S180, D10S197). 3 out of 1028 alleles studied in T-cell clones of normal healthy subjects, showed altered microsatellite size compared to other clones from the same individual. Thus the background MSDLV was estimated to 2.9 x 10-3. We then analysed the MSDLV and HPRT mutant frequency (MF) in a breast cancer patient belonging to a hereditary nonpolyposis colorectal carcinoma (HNPCC) family, with two different mutations in her hMLH1 genes. This compound heterozygote showed a frequency of microsatellite length variation of 18.9 % per allele, which was 50 times higher than the background frequency. The HPRT MF of 34.5 x 10-6 was elevated 2-3 times compared to controls. The HPRT mutational spectrum of this patient was significantly different from normal, with a shift from base pair substitutions towards frameshifts, especially + 1bp insertions, and deletions. Also two new basepair mutations not reported earlier were seen and two of the clones studied had two mutations each, which is very unusual. We concluded that the patient was likely to have a mild MMR deficiency in her somatic cells due to the mutations in both of her hMLH1 genes, and that this was the cause of her microsatellite instability (MSI), increased HPRT MF and abnormal HPRT mutational spectrum. The HPRT mutational spectrum was studied in 73 T-cell clones each from smoking and nonsmoking lung cancer patients. The proportions of different types of mutations, were not significantly different between smokers and nonsmokers, although the smokers had less deletions. The distribution of basepair substitutions was nonrandom, with clustering at previously identified hotspots at positions 143, 197 and 617 of the HPRT coding sequence. One additional hotspot at position 606 was observed, in smokers only. The frequency of GC>TA transversions (13%) was higher in smokers than in nonsmokers (6%). Conversely smokers had a lower frequency of GC>AT transitions (24 %) than nonsmokers (35 %).We concluded that there was a minor effect of smoking on the HPRT mutational spectra, with a trend for increase of GC>TA transversions and decrease of GC>AT transitions, in the smokers compared to the nonsmokers. This is consistent with the in vitro mutagenicity of benzo(a)pyrene, one of the prominent carcinogens of tobacco smoke. In conclusion, these results show that analysis of HPRT mutations may contribute to the understanding of somatic mutagenesis in vivo, and that the mutational spectrum at the HPRT locus may reflect abnormalities of repair and extensive environmental exposure, such as tobacco smoking.List of scientific papersI. Hackman P, Gabbani G, Österholm AM, Hellgren D, Lambert B. (1995). Spontaneous length variation in microsatellite DNA from human T-cell clones. Genes Chromosomes Cancer. 14(3):215-219. https://pubmed.ncbi.nlm.nih.gov/8589039II. Hackman P, Tannergård P, Osei-Mensa S, Chen J, Kane MF, Kolodner R, Lambert B, Hellgren D, Lindblom A. (1997). A human compound heterozygote for two MLH1 missense mutations. Nat Genet. 17(2):135-136. https://pubmed.ncbi.nlm.nih.gov/9326924III. Hackman P, Lindblom A, Nyström M, Marra G, Nicolova T, Lambert B (2000). Compound hMlH1 heterozygosity associated with abnormal spectrum of somatic mutations in a breast cancer patient belonging to a HNPCC family. [Manuscript]IV. Hackman P, Hou SM, Nyberg F, Pershagen G, Lambert B (2000). Mutational spectra at the Hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in T-lymphocytes of non-smoking and smoking lung cancer patients. Mutat Res. 468(1):45-61. https://pubmed.ncbi.nlm.nih.gov/10863157</p
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