12,430 research outputs found
Ms. Hackett
No full textMs. Hackett, on right, poses with an unidentified woman. Ruth L. Hackett worked as the Assoc. Professor of English from 1928 - 1942
Ruth L. Hackett
No full textRuth Hackett started working at tusculum college in 1928 and left in 1942. Hackett was the associate professor of english
R.G. Hackett with equipment working on railroad survey, Vancouver Island, British Columbia, between 1908 and 1915
No full textWritten on album page: R.G. Hackett Vancouver Island C.N.R. Survey.
PH Coll 233.4dTo order a reproduction, inquire about permissions, or for information about prices see: http://www.lib.washington.edu/specialcollections/services/reproduction/reproduction Please cite the Order Numbe
Men including R. G. Hackett with equipment working on railroad survey, Vancouver Island, British Columbia, between 1908 and 1915
No full textWritten on album page: R.G. Hackett Vancouver Island C.N.R. Survey.
PH Coll 233.4aTo order a reproduction, inquire about permissions, or for information about prices see: http://www.lib.washington.edu/specialcollections/services/reproduction/reproduction Please cite the Order Numbe
PH-sensitive nanoformulated triptolide as a targeted therapeutic strategy for hepatocellular carcinoma
No full textHepatocellular carcinoma (HCC) has one of the worst prognoses for
survival as it is poorly responsive to both conventional chemotherapy and
mechanism-directed therapy. This results from a lack of therapeutic concentration
in the tumor tissue coupled with the highly toxic off-site effects exhibited by these
compounds. Consequently, we believe the best packaging for holistic therapy for
HCC will involve three components: a potent therapeutic, a rationally designed
drug delivery vehicle to enrich the target site concentration of the drug, and a surface ligand that can enable a greater propensity to internalization by
tumor cells compared to the parenchyma. We screened a library containing hundreds of compounds against a panel of HCC cells and found the natural
product, triptolide, to be more effective than sorafenib, doxorubicin, and daunorubicin, which are the current standards of therapy. However, the potential
clinical application of triptolide is limited due to its poor solubility and high toxicity. Consequently, we synthesized tumor pH-sensitive nanoformulated
triptolide coated with folate for use in an HCC-subpopulation that overexpresses the folate receptor. Our results show triptolide itself can prevent disease
progression, but at the cost of significant toxicity. Conversely, our pH-sensitive nanoformulated triptolide facilitates uptake into the tumor, and specifically
tumor cells, leading to a further increase in efficacy while mitigating systemic toxicity.143441sciescopu
Cancer imaging: Lighting up tumours
No full textGao and colleagues have developed a polymeric, micelle-based nanoprobe that is highly responsive to both the angiogenic tumor vasculature and the extracellular pH. First, Gao and colleagues introduced tertiary amines with controlled hydrophobic substituents as ionizable hydrophobic blocks for the pH-sensitive core. Nanoprobes with different transition pH values can thus be achieved by using tertiary amino groups that protonate at a different pH. Subsequently the polymers were derivatized with hydrophobic fluorophores. At physiological pH, the monomers spontaneously assemble with the fluorophores oriented into the centre of the particle and in close proximity with each other. As a result of this, the fluorophores tend to silence each other by a process called fluorescence resonance energy transfer. As the particle navigates the body and enters the tumor site, the drop in pH begins to protonate the amines. The extremely high sensitivity makes these nanoprobes promising candidates for clinical tumor diagnosis.117181sciescopu
Multifunctional tumor pH-sensitive self-assembled nanoparticles for bimodal imaging and treatment of resistant heterogeneous tumors
No full textNanoparticle-based diagnosis-therapy integrative systems represent an emerging approach to cancer treatment. However, the diagnostic sensitivity, treatment efficacy, and bioavailability of nanoparticles as well as the heterogeneity and drug resistance of tumors pose tremendous challenges for clinical implementation. We herein report on the fabrication of tumor pH-sensitive magnetic nanogrenades (termed PMNs) composed of self-assembled iron oxide nanoparticles and pH-responsive ligands. These PMNs can readily target tumors via surface-charge switching triggered by the acidic tumor microenvironment, and are further disassembled into a highly active state in acidic subcellular compartments that ""turns on"" MR contrast, fluorescence and photodynamic therapeutic activity. We successfully visualized small tumors implanted in mice via unique pH-responsive T1MR contrast and fluorescence, demonstrating early stage diagnosis of tumors without using any targeting agents. Furthermore, pH-triggered generation of singlet oxygen enabled pH-dependent photodynamic therapy to selectively kill cancer cells. In particular, we demonstrated the superior therapeutic efficacy of PMNs in highly heterogeneous drug-resistant tumors, showing a great potential for clinical applications. © 2014 American Chemical Society.11901981sciescopu
An intracellular pH gradient in the anammox bacterium Kuenenia stuttgartiensis as evaluated by (31)P NMR
No full textThe cytoplasm of anaerobic ammonium oxidizing (anammox) bacteria consists of three compartments separated by membranes. It has been suggested that a proton motive force may be generated over the membrane of the innermost compartment, the “anammoxosome”. 31P nuclear magnetic resonance (NMR) spectroscopy was employed to investigate intracellular pH differences in the anammox bacterium Kuenenia stuttgartiensis. With in vivo NMR, spectra were recorded of active, highly concentrated suspensions of K. stuttgartiensis in a wide-bore NMR tube. At different external pH values, two stable and distinct phosphate peaks were apparent in the recorded spectra. These peaks were equivalent with pH values of 7.3 and 6.3 and suggested the presence of a proton motive force over an intracytoplasmic membrane in K.stuttgartiensis. This study provides for the second time—after discovery of acidocalcisome-like compartments in Agrobacterium tumefaciens—evidence for an intracytoplasmic pH gradient in a chemotrophic prokaryotic cell.BiotechnologyApplied Science
Concept and development of an autonomous wearable micro-fluidic platform for real time pH sweat analysis
No full textIn this work the development of an autonomous, robust and wearable micro-fluidic platform capable of performing on-line analysis of pH in sweat is discussed. Through the means of an optical detection system based on a surface mount light emitting diode (SMD LED) and a light photo sensor as a detector, a wearable system was achieved in which real-time monitoring of sweat pH was performed during 55 minutes of cycling activity. We have shown how through systems engineering, integrating miniaturised electrical components, and by improving the micro-fluidic chip characteristics, the wearability, reliability and performance of the micro-fluidic platform was significantly improved
Exploring the effect of the pH on the corrosion of multilayer nickel-chromium coatings
No full textThe impact of the pH on the corrosion of microporous nickel-chromium coatings has been explored at localised scale by Scanning Electrochemical Microscopy and validated by potentiodynamic polarisation measurements. Results not only reveal the correlation between both techniques but also enables to identify the different corrosion rate after increasing the electrolyte aggressiveness varying the pH. However, independently of the pH, a similar corrosion mechanism was determined: the cross-section micrographs (by Field Emission-Scanning Electron Microscope) have revealed an isotropic growth of the actives sites at early-stage corrosion as well as the attack of different nickel layers during the corrosion propagation.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Team Yaiza Gonzalez Garci
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