95,098 research outputs found
WATER-RESOURCES ENGINEERING Chapter 11 : Pressure Conduits
No full textwater. water--resources. resources. engineering. engineering. chapter 11 : pressure. chapter 11 : pressure conduits. conduits. ming. ming. -. -. hsi hsu. hsi hsu. professor. professor. department of bioenvironmental systems engineerin
Autocrine Growth Regulation of Cd30 Ligand in Cd30-Expressing Reed- Sternberg Cells: Distinction between Hodgkin's Disease and Anaplastic Large Cell Lymphoma
No full textPersistent expression of high levels of CD30 in Hodgkin's Reed-Sternberg (H-RS) cells and anaplastic large-cell lymphoma (ALCL) cells, but not in most T- or B-cell lymphomas, suggests the presence of an underlying mechanism leading to the abnormality and possible involvement of CD30 in the growth and survival of these two unique types of tumors. In this study , we examined the effect of CD30 ligand (CD30L) on CD30-positive H-RS and ALCL cells in long-term cultures or in primary cultures. CD30L induced various degrees of proliferation in three long-term cultured H-RS cell lines (L428, HDLM-2, and KM-H2) as well as in primary cultures of H-RS cells obtained directly from patients with Hodgkin's disease. In contrast, significant inhibition was observed in one of the ALCL cell lines (SU-DHL -1), but no growth inhibition or promotion in responding to exogenous CD 30L was detected in three others (PB-1, JB-6, and McG-2), nor in primary cultures of ALCL cells. Expression of CD30L was determined by polymerase chain reaction in long-term cultured cells and by an immunohistochemical method in H-RS or ALCL cells de novo in tissue sections. None of the H-RS and ALCL cell lines was positive for CD30L. In tissue sections, we noticed that ALCL cells were generally CD30L- negative. In contrast, the anti-CD 30L antibody reacted with a majority of H-RS cells with diffuse cytoplasmic staining. Most H-RS cells were CD30-positive, indicating co- expression of CD30 and CD30L in the majority of lymphoma cells. The persistent high levels of CD30 and CD30L expression in H-RS cells suggest that the autocrine CD30L-CD30 cytokine- receptor loop, in addition to having the paracrine activity previously thought to exist, could play important roles in the proliferation of H-RS cells. In contrast, the CD30L - mediated cytotoxicity may participate in the regression or slow progression of ALCL during the early phase of the disease in selected patients. However, when the disease progresses, the ALCL cells are likely to become resistant to exogenous CD30L
COMPETENCE, COMPLICITY AND COMPLEXITY: HSU-MING TEO ON THE PITFALLS AND NUANCES OF READING AND RESEARCHING POPULAR ROMANCE
No full textInterview with popular romance scholar Hsu-Ming Teo.In this interview, writer and academic Hsu-Ming Teo analyses the Misconceptions made by feminist critics in their approach to romantic fiction. An outstanding representative of the third wave of romance criticism, Teo highlights the pitfalls and nuances of reading popular romances and explains that current criticism relies on a distinctive genre reading competence, a respectful complicity with readers’ viewpoints and the recognition of the diversity of voices and experiences the genre is giving visibility to. All of these aspects call for interdisciplinary approaches that consider both textual and paratextual aspects
Hsu-Ming Teo’s Post-Multicultural Affective Improvisations on Love
No full textThis essay juxtaposes the academic writings of the Chinese Malaysian Australian writer Hsu-Ming Teo with two or her novels. The essay traces how the cultural politics of multiculturalism have changed over the past decades in Australia. Using the framework of Jean-François Lyotard’s future anterior, in which post-multiculturalism is imagined as going back to find elements left out of the current historicizing of multiculturalism, Gunew situates Teo’s work in a critically astute “uncomfortable cosmopolitanism” pervaded by her interest in the affective charge contained in contemporary popular romance writing that deals with intercultural relationships
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Pursuing citizenship in the enforcement era /
No full text"Ming Hsu Chen provides readers with the everyday perspectives of immigrants on what it is like to try to integrate into American society during a time when immigration policy is focused on enforcement and exclusion"-
Abundance of Heat Shock Proteins (Hsp89, Hsp60, and Hsp27) in Malignant Cells of Hodgkin's Disease
No full textHeat shock proteins (HSPs) or stress proteins are synthesized by cells in response to environmental stress. Expression of HSPs by cells may have important physiological or pathological implications. In this study, we carried out an immunohistochemical and biochemical examination of low ( hsp27), intermediate (hsp60), and high (hsp89) molecular weight HSP expression in reactive lymph nodes and in lymph nodes of patients with various types of lymphomas. In normal or reactive lymphoid tissues, hsp89 is abundant in large " transformed" lymphoid cells and immunoblasts. Hsp60 is widely distributed in lymphoid tissues, whereas hsp27 is absent in all lymphoid cells and histiocytes. Among lymphomas, the Hodgkin's Reed- Sternberg (H-RS) cells in Hodgkin's disease (HD) had the greatest abundance of hsp89 and hsp60 and, in 20% of cases, hsp27, in contrast to a much weaker staining of anti-hsp89 and -hsp60 in the background reactive lymphoid cells. The large lymphoid cells in small lymphocytic lymphoma are also rich in hsp89, but not hsp60 and hsp27. In contrast, the malignant cells in anaplastic large cell lymphoma and most high-grade tumors, including immunoblastic Lymphomas, expressed minimal amounts of hsp89 and hsp60 and virtually no hsp27. Thus, the cellular level of HSPs was neither correlated with the proliferative capacity nor with the aggressiveness of the lymphomas. Hsp89 , hsp60, and hsp27, as well, serve critical roles in the chaperoning of cellular proteins (e.g., a M-r 43,000 protein ) in H- RS cells. The known interactions of HSPs with Rb, p53 , peptide-MHC class II complexes, and cofactors of the glucocorticoid hormone receptor have further broadened the importance of HSPs in cell metabolism and in response to extracellular signals for proliferation, differentiation, or growth suppression (or apoptosis) of H-RS cells. Abundant HSP expression is seen only in HD, but not in other lymphomas. Such expression could have vital roles in the pathogenesis of HD
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