26,923 research outputs found
How Were the Elderly RA Patients Doing Over the Past Year?—A Post Hoc Analysis for Telephone Based Following Up to RA Patients in Zunyi China
No full textYong Chen,1 Yan-Juan Chen,1 Jian-Feng Luo,2 Mang He,1 Si-Jin Zhao,3 Shi-Dan Tian,1 Yong-Qiao Zhang,3 Xiao-Long Chen,3 Chuan-Jie Yang,3 Yu-Zhuo Luo,3 Kutty Selva Nandakumar,4 Mei Tian1 1Department of Rheumatology and Immunology, Affiliated Hospital of Zunyi Medical University, Zunyi, People’s Republic of China; 2Department of Biostatistics, School of Public Health, Fudan University, Shanghai, People’s Republic of China; 3The First School of Clinical Medicine, Zunyi Medical University, Zunyi, People’s Republic of China; 4Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, SwedenCorrespondence: Mei Tian, Department of Rheumatology and Immunology, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Huichuan District, Zunyi City, Guizhou Province, 563000, People’s Republic of China, Email [email protected] Kutty Selva Nandakumar, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, 17177, Sweden, Email [email protected]: The quality of life (QoL) of elderly patients with rheumatoid arthritis (RA) in Zunyi China based on health parameters has not been previously analyzed. This study compares the 36-Item Short Form Health Survey (SF-36) scores and prevailing health complications between < 60y and ≥ 60y patients with RA. Data from 1166 patients with RA who visited the rheumatology department of Zunyi Medical University Hospital were followed up and retrospectively analyzed.Patients and Methods: Data from 1166 patients with RA who visited the rheumatology department of Zunyi Medical University Hospital (2021.1– 2022.8) were followed up and retrospectively analyzed.Results: Twenty cases passed away at 61.55 ± 8.11y, which was 6.75 years less than the local average age of death. Elderly patients with RA reported lower recovery levels, and their levels of inflammatory markers such as Immunoglobulin M-rheumatoid factor (IgM-RF), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were significantly higher than those of younger patients during their past one-year observation period. The SF-36 results indicated that eight items of QoL in the elderly patients were all significantly inferior to < 60y patients, while the complications of interstitial lung disease (ILD), latent tuberculosis infection (LTBI) and, lung and herpes zoster infections were significantly higher.Conclusion: Elderly patients had a higher disease activity along with poor QoL, more health-related complications, and susceptibility to infections. Our study emphasizes the imperative need for optimization of RA treatment modalities in the elderly to alleviate their sufferings.Keywords: elderly rheumatoid arthritis, SF-36 scores, clinical characteristics, treatment outcome
Strategic directions in the what and how of learning and teaching innovation—a fifty-year synopsis
No full textStudent learning experiences at university are constantly evolving; new disciplinary discoveries, new knowledge, interdisciplinary synergies and new exigencies make learning a dynamic experience for students, teachers and researchers alike; and that is just the what of learning. Add to this, changes in the how of learning, new pedagogies and new technologies, new partners in the provision of learning, as well as new configurations of where learning takes place, such as on campus, at home, in the workplace and online; and it is not hard to make the case that learning experiences of students enrolled in a degree are relatively more complex today than they were even 20 years ago. Much of this change has been captured over the last five decades in the journal Higher Education. The ongoing challenge of these changes is the complexity that accompanies them. How do we improve the student experience of learning in a complex context? What should the outcomes of a higher education degree be? What learning processes are likely to lead better outcomes? How do you assess the quality of learning that may occur in small groups on campus or online, or in large groups in both places, or in laboratories or the workplace? What is the role of material objects in these experiences and do they contribute to outcomes? This manuscript will consider such questions and where the journal is pointing researchers towards new avenues that are developing in learning and teaching internationally
Rayleigh number dependence of the Archimedes number dependent large-scale flow structure formation in mixed convection
No full textWe report on experimental investigations of large-scale flow structure formation in mixed convection. We characterize the flow field by measuring the velocity fields within a rectangular model room using 2D2C PIV. The control parameters are the Reynolds number Re, the Rayleigh number Ra and the Prandtl number Pr. All parameters are linked through the Archimedes number Ar. In 6.4x10-2 ≤ Ar ≤ 1.39x101, 4.2x103 ≤ Re ≤ 6.35x104 and Ra = 3.1x107, Ra = 1.8x108 and Pr = 0.713 we found flow 3 different flow structures. While keeping Ra and Pr constant and varying Ar through Re variations, we found an Ar dependence of the largescale flow structure formation within 6.4x10-2 ≤ Ar ≤ 1.39x101. Furthermore, we found a Ra dependence of the structure formation, which shifts the transition points between the structures to higher Archimedes numbers and reduces the mean velocities within the investigated domain
Wall to wall optimal transport
No full textThe calculus of variations is employed to find steady divergence-free velocity fields that maximize transport of a tracer between two parallel walls held at fixed concentration for one of two constraints on flow strength: a fixed value of the kinetic energy or a fixed value of the enstrophy (the mean square rate of strain in this situation). The optimizing flows realize upper limits on convective transport in this scenario. We interpret the results in the context of buoyancy-driven Rayleigh–Bénard convection problems that satisfy the flow intensity constraints, enabling us to investigate how optimal transport scalings compare with upper bounds on Nu expressed as a function of the Rayleigh number Ra
Teerk Roo Ra Residencies
No full textA series of works based on the Peel Island Residencies on Teerk Roo Ra in Moreton Bay during 2010/2011.\ud
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This work was part of a larger research project, which was concerned with using animation to convey a sense of place. The primary investigation focused on the heritage site of the former Peel Island Lazaret, on the island of Teerk Roo Ra in Moreton Bay, Queensland. The project aimed to develop a style of motion that embodied the 'genius loci', or 'sense of place' of that site. The study investigated how conceptions of place are overlaid by aspects of history, memory and the imagination and contributed to the academic discourse around place and place-making in animation practice in Australia. \ud
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The methodology for the project was designed to span multiple production cycles over a period of six years, and used this structure as a means to provoke practice through engaging with a variety of locations, mediums and display formats. Each exhibition and public presentation contributed to the development of the overall project , and the culmination of the project was the creation of a style of motion design which employed a method of transposing stereotypic movement patterns onto bespoke hand crafted armatures as a means of conveying the sense of place of the Peel Island Lazaret. A series of animated creative works were constructed using this method and were subsequently published and discussed across a variety of formats.\ud
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The measures for significance of this project are geographic reach and peer validation which ranged from curated white cube and black cube exhibitions, exhibitions at regional and commercial galleries, public programs, local and international artist residencies, paid commissions with public screenings through to printed catalogs with academic essays. A range of publicity has promoted the research displayed at these public events, which has also been presented at 4 national and international conferences. 'Nocturne #5' (2015) ultimately won a national prize at the CCP salon in Melbourne 2015
Reynolds numbers near the ultimate state of turbulent Rayleigh-Bénard convection
No full textWe report on measurements of the mean-flow Reynolds number ReU and the rms fluctuation Reynolds number ReV in turbulent Rayleigh-Bénard convection as a function of the Rayleigh number Ra for 4 x 1011 < Ra < 2 1014 and Pr ' 0:8. Both can be described by the same power law with an effective exponent = 0:44, in agreement with predictions for ReU but in disagreement with predictions for ReV
Logarithmic variance profiles and the corresponding f-1 spectra of temperature fluctuations in turbulent Rayleigh-Bénard convection
No full textWe report experimental results for the temperature variance 2(z) and the corresponding frequency spectra P(f) in turbulent Rayleigh-Bénard convection (RBC) in a cylindrical sample of aspect ratioT= D/L = 1:00 (D = 1:12 m is the diameter and L = 1:12 m the height). The measurements were conducted in the Rayleigh-number range 1011 < Ra < 1:35 1014 and Pr ' 0:8. For Ra = 1:35x1014, 2(z) could be described well by a logarithmic dependence on the vertical position z in a range of z 1 < z < z 2 with z 1 ' 70 and z 2 = 0:1L. Here L=(2Nu) is the thickness of a thin thermal sublayer adjacent to the horizontal plate where the heat flux (denoted by the Nusselt number Nu) is carried mostly by thermal diffusion. In the log layer, we found that the temperature spectra had a significant frequency range over which P(f) f with close to 1. As Ra decreased, increased so that the log layer became thinner. At Ra = 2:05 1011, z 2 < z 1 and therefore there was no range for a log layer. Correspondingly, the temperature spectrum near the horizontal plate did not have the f1 scaling form either
PENGARUH KEGIATAN OUTBOUND TERHADAP MOTORIK KASAR ANAK DI KELOMPOK A RA AL-FATTAH BLOK SUKAMURNI DESA MAJA SELATAN KECAMATAN MAJA
No full textThis research begins with the problem of underdeveloped gross motor skills in group A children, this is due to the ineffective use of strategies or learning methods as well as the delivery of learning that is less attractive to children, so children are less interested in the learning process. To overcome the above problems, the researchers used Outbound activities to improve the gross motoric skills of children in group A RA Al-Fattah Sukamurni, South Maja Village, Majalengka Regency 2018-2019 Academic Year with a total of 13 children. This study aims to determine how much influence the outbound activities have on gross motor children. This research begins with the problem of underdeveloped gross motor skills in group A children, this is due to the ineffective use of strategies or learning methods as well as the delivery of learning that is less attractive to children, so children are less interested in the learning process. To overcome the above problems, the researchers used Outbound activities to improve the gross motoric skills of children in group A RA Al-Fattah Sukamurni, South Maja Village, Majalengka Regency 2018-2019 Academic Year with a total of 13 children. This study aims to determine how much influence the outbound activities have on gross motor children. Learning outcomes using Outbound Activities in improving children's gross motor skills are shown from the analysis of the data that researchers obtained namely tcount of 8.6. To determine t-table in this study, the calculation is carried out with the formula of degrees of freedom (df) and get a result of 12, then at a significant level of 5% with df 12 of 1.782, a significant level of 1% is 2.681. It can be concluded that the table 5% is 1,782 and 1% is 2,681. smaller than t_count of 8.6 then Ha is accepted Ho is rejected. This means that there is an influence between outbound activities on the gross motoric of children in RA Al-Fattah Sukamurni Maja Selatan Maja District Majalengka Regency
How does retinoic acid (RA) signaling pathway regulate spermatogenesis?
No full textMale sterility is a worldwide health problem
which has troubled many unfortunate families and
attracted widespread attention in the field of
reproduction. Retinoic acid (RA) is a metabolite of
vitamin A. Previous studies have shown that insufficient
intake of vitamin A can lead to male infertility.
Similarly, RA-deficiency can lead to abnormal
spermatogenesis in men. RA signaling is inseparable
from hormone stimulation, such as FSH, testosterone
and others. It can regulate spermatogenesis as well,
including the proliferation and differentiation of
spermatogonia, meiosis, spermiogenesis and
spermiation. To promote or inhibit spermatogenesis, RA
regulates Stra8, Kit, GDNF, BMP4 and other factors in
various pathways. At the self-renewal stage, RA inhibits
spermatogonia renewal by directly or indirectly
inhibiting DMRT, GDNF and Cyclin. At the stage of
differentiation and meiosis, RA controls SSC
differentiation through Kit induction and Nanos2
inhibition, and controls spermatogonia meiotic entry
through up- regulation of Stra8. At the stage of
spermiogenesis, RARα, as a key regulator, regulates
spermatogenesis by up regulating Stra8 while binding
with RA. Although RA plays an important role in all
stages of spermatogenesis, RA signaling is more
important in the early stage of spermatogonia (spg)
differentiation and spermatocyte (spc) meiosis.
According to the principle of RA signaling that regulates
spermatogenesis, we also speculate on the future clinical
application of RA, such as potential induction of SSC in
vitro, contraception and restoring spermatogenesis. This
paper reviews the regulatory pathways of RA, and
prospects the clinical applications of RA signaling in the
future
Lagrangian analysis of turbulent rotating convection
No full textThis study aims to explore how the flow transition from one state to the other in rotating convection will affect the Lagrangian statistics of (fluid) particles. 3D Particle Tracking Velocimetry (3D-PTV) is employed in a water-filled cylindrical tank of equal height and diameter 200 mm. The measurements are performed in the central volume of 50 × 50 × 50 mm3 at a Rayleigh number Ra = 1.28 × 109 and Prandtl number Pr = 6.7. We are reporting the velocity and acceleration pdfs for different Rossby numbers. For different rotation rates, the transverse velocity pdfs show a Gaussian distribution. The vertical velocity pdf has slightly wider tails for stationary and high rotation rate cases, while it approaches the Gaussian distribution for intermediate rotation rates. The acceleration pdfs have significantly wider tails in comparison to those of a Gaussian distribution which is similar to the other turbulent flows. Increasing rotation results in less intermittency in vertical acceleration in the center of RB
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