3,791 research outputs found
Radon and thoron emission from high and low porosity rocks under increasing deformation: An experimental study.
No full textThe fire resistance of high-strength concrete containing natural zeolites
No full textMore sustainable and environmentally friendly concretes are essential to reduce the climatic and environmental impact of the growing demand for concrete to fuel urban sprawl. This manuscript reports on an experimental study designed to test the fire resistance of one such concrete, prepared to contain natural zeolite-bearing tuff. The fire resistance of concretes containing natural zeolites has received little attention and is therefore poorly understood. Relative reductions in residual uniaxial compressive strength as a function of increasing temperature (up to 1000 °C) were very similar for the reference concrete (containing no tuff) and the tuff-bearing concrete. These data can be explained by the similar influence of high-temperature on the chemical (dehydroxylation reactions) and physical (microcracking and porosity) properties of both concretes. The satisfactory performance of the concrete containing natural zeolites following fire is welcome owing to the economic, climatic, and environmental benefits of using natural pozzolan and aggregate substitutes
Self-compression of 4.9 µm pulses to sub-40 fs with 2 mJ energy in Zinc Sulfide
No full textNonlinear self-compression of few-cycle multi-mJ pulses at 4.9 µm in ZnS is presented. 80 fs input pulses are compressed to 37 fs with 2.1 mJ energy at a 1 kHz repetition rate. © 2024 The Author(s
Assigning function to genome wide association study variants associated with complex gastrointestinal disease
No full textPhDThe genome‐wide association study era has identified numerous loci associated with many
common polygenic diseases. The next challenge is to identify the functional consequences
of these variants and elicit how they impact on disease risk. Using a combination of protein
based assays, large scale microarrays and high‐throughput generation sequencing
platforms this thesis aims to identify the functional effects of disease loci, with particular
focus on Crohn’s disease and coeliac disease, two common complex gastrointestinal
diseases.
Variants located within the Interleukin 23 receptor are associated with both susceptibility
and protection from Crohn’s disease, a debilitating chronic inflammatory disease of the
bowel. A study was undertaken to investigate the effect of these variants, at the mRNA as
well as the protein level, on both cytokine and receptor levels.
Coeliac disease is a dietary intolerance to the gluten component of wheat, barley and rye
and has an estimated prevalence of approximately 1%. Genome‐wide association studies
have identified eight genomic different loci as associated with coeliac disease but none
have been functionally characterised. To investigate the effect that genotype has on gene
transcript levels, a genetical genomics study was undertaken in patients with coeliac
disease generating results with relevance to a range of autoimmune disorders.
Before disease based effects can be identified, it is first important to fully characterise the
normal human transcriptome and methylome. To this end CD4
+ T cells were studied using
novel high‐throughput sequencing techniques, with the aim of providing some insight into
novel genomic properties that may illuminate current and future disease associated loci.
Given the base pair resolution approach of high‐throughput sequencing, a novel method of
assaying for SNP effects on gene expression was developed. This allele specific method,
using whole transcriptome sequencing, is capable of identifying alterations in transcript
expression on a genome‐wide scale
Correction to: Chamoun et al., Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection
No full textChamoun MN, Blumenthal A, Sullivan MJ, Schembri MA, Ulett GC. 2018. Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology. https://doi.org/10.1080/1040841X.2018.1426556.
When the above article was first published online, the below three corrections were missed.
The author ‘Antje Blumenthal’ was wrongly affiliated to the affiliation “cSchool of Chemistry and Molecular Biosciences, and Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Australia”. Now this affiliation has been removed for this author.
The affiliation ‘bTranslational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia’ of the author ‘Antje Blumenthal’ should read ‘bThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia’.
In Table 3, the sentence ‘Benefit of manipulating IL-17 levels to improve immunization strategies M. tuberculosis’ should read “Benefit of manipulating IL-17 levels to improve immunization strategies against M. tuberculosis”.No Full Tex
Generation of 22-mJ, 2.0-ps Pulses from a 1-kHz Ho:YLF Regenerative Chirped Pulse Amplifier
No full textWe report a CW-pumped Ho:YLF regenerative amplifier (RA) delivering pulses with 22.5-mJ energy and 2.0-ps duration at 1 kHz. The RA emitting at 2051 nm is broadband-seeded and implemented in a chirped pulse amplification system. © 2024 The Author(s
Influence of temperature on brittle creep in sandstones
No full textThe characterization of time-dependent brittle creep, promoted by chemically active pore fluids, is fundamental to our understanding of the long-term evolution and dynamics of the Earth's crust. Here we report results from a study of the influence of temperature on both short-term strength and time-dependent brittle creep in three sandstones under triaxial stress conditions. We show that an increase in temperature from 20 degrees to 75 degrees C significantly enhances stress corrosion cracking in all three sandstones, leading to (1) a systematic reduction in strength during constant strain rate experiments and (2) an increase by several orders of magnitude in brittle creep strain rates during stress-stepping creep experiments. We also show that a conventional creep experiment performed at 75 degrees C exhibits a qualitatively similar three-stage brittle creep curve as that observed at ambient temperature. Extrapolation of our results suggests that temperature is likely to be the dominant influence on the evolution of creep strain rate with depth in the shallow crust. Citation: Heap, M. J., P. Baud, and P. G. Meredith (2009), Influence of temperature on brittle creep in sandstones, Geophys. Res. Lett., 36, L19305, doi: 10.1029/2009GL039373
Pure-rotational 1D-CARS spatiotemporal thermometry with a single regenerative amplifier system
No full textWe report spatiotemporal pure-rotational coherent anti-Stokes Raman spectroscopy (CARS) in a one-dimensional imaging arrangement obtained with a single ultrafast regenerative amplifier system. The femtosecond pump/Stokes photon pairs, used for impulsive excitation, are delivered by an external compressor operating on a ∼35% beam split of the uncompressed amplifier output (2.5 mJ/pulse). The picosecond 1.2 mJ probe pulse is produced via the second-harmonic bandwidth compression (SHBC) of the ∼65% remainder of the amplifier output (4.5 mJ/pulse), which originates from the internal compressor. The two pump/Stokes and probe pulses are spatially, temporally, and repetition-wise correlated at the measurement, and the signal generation plane is relayed by a wide-field coherent imaging spectrometer onto the detector plane, which is refreshed at the same repetition rate as the ultrafast regenerative amplifier system. We demonstrate 1 kHz cinematographic 1D-CARS gas-phase thermometry across an unstable premixed methane/air flame-front, achieved with a single-shot precision <1% and accuracy <3%, 1.4 mm field of view, and an excellent <20 µm line-spread function.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Flight Performance and Propulsio
Project: Establishing an accounting outsourcing company "MJ Grāmatvedība" Ltd
No full textProjekta ideja ir izveidot grāmatvedības ārpakalpojumu uzņēmumu SIA „MJ Grāmatvedība”, kurš sniegtu pilna vai daļēja cikla grāmatvedības pakalpojumus, sākot ar pirmreizējo dokumentu apstrādi un beidzot ar visu nepieciešamo atskaišu sagatavošanu, kā arī konsultāciju sniegšanu. Projekta mērķis ir ne tikai sniegt grāmatvedības pakalpojumus, bet arī analizēt uzņēmumu darbību un izstrādāt ieteikumus darbības uzlabošanai. Darba autore uzskata, ka nozares pārstāvjiem ir būtiski jāpierāda sava nozīme un to kādam jābūt mūsdienu grāmatvedim. Grāmatvedis nav tikai persona, kura izdara konkrētus darbus, nodos atskaites, tas ir cilvēks, kuram labi jāpārzina nodokļu sistēma, finanšu vadīšana, jāspēj sniegt padomus uzņēmuma finanšu vadības uzlabošanai, kā arī jāspēj pielāgoties tehnoloģiju radītajām izmaiņām. Maģistra darbs apjoms ir uz 105 lappusēm, kas sastāv no 7 nodaļām, 17 pielikumiem, 22 tabulām un 7 attēliem. Darba izstrādē izmantoti 70 informācijas avoti.The general project idea is to establish the accountancy firm MJ Accountancy Ltd., which would provide full or half-cycle accountancy services including the processing of primary documentation, reports’ preparation, and providing of the accountancy consultations. The aim of the project is not only to provide accountancy consultations but also to deal with firms activity analysis and developing suggestions on their activity improvement. The author of the project supports the idea that the field representatives must constantly sustain the status of the accountant’s profession in current times. The accountant is not only the person who executes one’s regular duties and submits reports, but also the person who is competent in the field of taxes, financial management, able to advise on improvements in financial management, and above all able to adapt to the technological changes. The volume of the project is 105 pages, which includes 7 chapters, 17 appendices, 22 tables, 7 figures. 70 sources of information were used in master’s thesis
Initial state and transition-state solvation effects in the cobaltotungstate oxidation of iodide in binary aqueous solvent mixtures
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