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Model engine data sheets and operating instructions, G - I, 1978-1980, 1983, 2022
No full textHB-Engines parts list for model engines
Markkinointisuunnitelma : case: HB Promotion
No full textOpinnäytetyön tarkoituksena oli tuottaa toimeksiantajalle markkinointisuunnitelma, markkinoinnin vuosikalenteri sekä viikkotasoinen somekalenteri. Opinnäytetyön toimeksiantajana toimi HB Promotion. Opinnäytetyön tavoitteena oli toimeksiantajan pyynnöstä tehostaa ja helpottaa markkinoinnin suunnittelua. Työssä käytettiin apuna erilaisia markkinoinnin teorioita sekä analyyseja.
Opinnäytetyö koostuu teoriaosuudesta ja toiminnallisesta osuudesta. Tutkimuskysymyksenä oli ”Millä eri keinoilla HB Promotionin markkinoinnin suunnitelmallisuutta voidaan kehittää?”
Opinnäytetyön teoriaosuudessa käsiteltiin markkinoinnin kilpailukeinoja sekä markkinoinnin suunnittelua. Teoriaosuus pohjautuu alan kirjallisuuteen ja erilaisiin verkkojulkaisuihin. Toiminnallisen osuuden rakentamisessa käytettiin havainnointia, toimeksiantajan haastattelua sekä erilaisia analyyseja.
Työn lopputuloksena saatiin toimivat suuntaviivat markkinoinnin suunnittelulle, markkinoinnin vuosikalenteri sekä viikkotasoinen somekalenteri. Markkinointisuunnitelman avulla saatiin tuotettua käyttökelpoisia toimenpiteitä, joiden avulla yrityksen markkinoinnin suunnitelmallisuutta pystytään kehittämään
Hb-α and Hb-β expression in hPVECs and VK2/E6E7 cells at protein level.
No full text(A, B). Immunofluorescence localization of Hb-α and Hb-β. Cytoplasmic localization (green) of Hb-α (A) and Hb-β (B) was observed in hPVECs (a,b,c) and VK2/E6E7 cells (d,e,f). DAPI stained nucleus (blue). a, d: Untreated cells; b,e: LPS treated cells; c,f: Primary antibody controls did not show Hb-α and Hb-β localization. Expression was significantly up-regulated when hPVECs and VK2/E6E7 cells stimulated with LPS (10 μg/ml for 6 hrs) (b, e). The figure shown is one of the representative pictures from three independent experiments performed on three different days (Mag. 63X). (C). Western blot analysis of Hb-α and Hb-β expression in hPVECs and VK2/E6E7 cells. β-actin (42 kDa) (loading control) expression in hPVECs (1: Untreated hPVECs, 2: hPVECs induced with LPS, 3: Untreated VK2/E6E7 cells and 4: VK2/E6E7 cells induced with LPS). (D). Densitometric analysis of bands from western blot of Hb-α and Hb-β shown in Fig 7C.</p
hb-P2 MS2 reporter data
No full textMS2-MCP live imaging data of the hb-P2 MS2 reporter used for the manuscript: Fernandes, Tran et al. Synthetic deconstruction of hunchback regulation by Bicoi
Hb-induced IL-6 via TLR9 and contributes to pulmonary artery smooth muscle cell metabolic activation.
No full text(A) IL-6 expression in rPAEC exposed to either CpG, or Hb (25 uM heme) in the presence or absence of TLR9 inhibitor 4084, Hp or Hpx. (B) Smooth muscle cell proliferation 24 h after exposure to Hb-activated endothelial cells in a co-culture system. Rat PAEC were activated with either CpG or Hb (25 uM) in the presence or absence of TLR9 inhibitor 4084, Hp (Hb-Hp) or Hpx (Hb+Hpx). (C) Smooth muscle cell proliferation in rat PASMC that were directly exposed for 24 h to low dose Hb (0.5, 1 and 20 uM heme). (D) Smooth muscle cell proliferation at 24 h after exposure to Hb-activated endothelial cells in a co-culture system. Rat PAEC were activated with Hb (25 uM heme) in the presence or absence of an IL-6 antibody. * p ≤ 0.04 vs. ctrl.</p
hb-P2 MS2 reporter in Bcd-1X (delta-bcd) data
No full textMS2-MCP live imaging data of the hb-P2 MS2 reporter in Bcd-1X (bcd-delta/+) used for the manuscript: Fernandes, Tran et al. Synthetic deconstruction of hunchback regulation by Bicoi
The mitogenic potential of heparin-binding epidermal growth factor in the human endometrium is mediated by the epidermal growth factor receptor and is modulated by tumor necrosis factor-alpha
No full textHeparin-binding epidermal growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, is implicated in a variety of biological processes, including reproduction. Previous studies describe increased levels of HB-EGF in the human endometrium during the midsecretory stage of the menstrual cycle, suggesting a function for HB-EGF in implantation of the human blastocyst. Here we have investigated the expression and function of the soluble and transmembrane forms of HB-EGF in the human endometrium. We show that the expression of the transmembrane form of HB-EGF in the human endometrium is modulated according to the stage of the menstrual cycle. We present data demonstrating that both the soluble and transmembrane forms of HB-EGF induce DNA synthesis in human endometrial stromal cells. Furthermore, TNFalpha has a cooperative effect on HB-EGF, EGF, TGFalpha, and betacellulin-induced DNA synthesis in stromal cells, suggesting roles for the EGF family and TNFalpha in regeneration and maturation of human endometrium. Induction of DNA synthesis by HB-EGF and its modulation by TNFalpha in endometrial stromal cells are mediated by the EGF receptor and not the HB-EGF receptor ErbB4. Our data suggest key functions for HB-EGF, TNFalpha, and the EGF receptor in endometrial maturation, via autocrine/paracrine and juxtacrine pathways, in preparation for embryo implantation
Hydroxyurea decreases hospitalizations in pediatric patients with Hb SC and Hb SB+ thalassemia
No full textJeffrey D Lebensburger, Rakeshkumar J Patel, Prasannalaxmi Palabindela, Christina J Bemrich-Stolz, Thomas H Howard, Lee M HilliardDivision of Pediatric Hematology Oncology, University of Alabama at Birmingham, Birmingham, AL, USAPurpose: Patients with hemoglobin SC (Hb SC) and hemoglobin SB+ (Hb SB+) thalassemia suffer from frequent hospitalizations yet strong evidence of a clinical benefit of hydroxyurea (HU) in this population is lacking. Patients with recurrent hospitalizations for pain crisis are offered HU at our institution based on small cohort data and anecdotal benefit. This study identifies outcomes from a large cohort of patients with Hb SC and SB+ thalassemia who were treated with HU for 2 years.Materials and methods: A retrospective review was conducted of 32 patients with Hb SC and SB+ thalassemia who were treated with HU. We reviewed the number, and reasons for hospitalization in the 2 years prior to, and 2 years post-HU treatment as well as laboratory changes from baseline, over 1 year.Results: Patients with Hb SC and SB+ thalassemia started on HU for frequent pain, had a significant reduction in hospitalizations over 2 years as compared to the 2 years prior to HU initiation (mean total hospitalizations/year: pre-HU: 1.6 vs post-HU 0.4 hospitalizations, P<0.001; mean pain hospitalizations/year: pre-HU 1.5 vs post-HU 0.3 hospitalizations, P<0.001). Patients demonstrated hematologic changes including an increase in percent fetal hemoglobin (%HbF) pre–post HU (4.5% to 7.7%, P=0.002), mean corpuscular volume (74 to 86 fL, P<0,0001), and decrease in absolute neutrophil count (5.0 to 3.2×109/L, P=0.007). Patients with higher doses of HU demonstrated the greatest reduction in hospitalizations but this was unrelated to absolute neutrophil count.Conclusion: This cohort of patients with Hb SC and SB+ thalassemia provides additional support for using HU in patients with recurrent hospitalizations for pain. A large randomized multicenter trial of HU to reduce pain admissions should be conducted to confirm these data and provide much needed evidence based recommendations for this population.Keywords: sickle cell disease, hydroxyurea, outcomes research, vaso-occlusive pain crisi
On the Security of Non-Linear HB (NLHB) Protocol Against Passive Attack
No full textAs a variant of the HB authentication protocol for RFID systems, which relies on the complexity of decoding linear codes against passive attacks, Madhavan et al. presented Non-Linear HB(NLHB) protocol. In contrast to HB, NLHB relies on the complexity of decoding a class of non-linear codes to render the passive attacks proposed against HB ineffective. Based on the fact that there has been no passive solution for the problem of decoding a random non-linear code, the authors have claimed that NLHB’s security margin is very close to its key size. In this paper, we show that passive attacks against HB protocol can still be applicable to NLHB and this protocol does not provide the desired security margin. In our attack, we first linearize the non-linear part of NLHB to obtain a HB equivalent for NLHB, and then exploit the passive attack techniques proposed for the HB to evaluate the security margin of NLHB. The results show that although NLHB’s security margin is relatively higher than HB against similar passive attack techniques, it has been overestimated and, in contrary to what is claimed, NLHB is vulnerable to passive attacks against HB, especially when the noise vector in the protocol has a low weight
3 HB mantapkan kolaborasi universiti industri
No full textKUANTAN, 27 November 2023 - Pengarah Bahagian Hubungan Industri, Jabatan Pendidikan Tinggi, Kementerian Pendidikan Tinggi (KPT), Dato' Mohd Sharil Abdullah menggariskan ‘3 HB’ dalam mempergiat usaha dalam mengenal pasti keperluan universiti-industri pada masa hadapan selaras dengan keperluan Pelan Induk Perindustrian Baharu 2030 (New Industrial Master Plan - NIMP 2030)
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