8,429 research outputs found
Erratum to “KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production
No full textThe order of authors in the above-referenced article should have read as follows: Ran Chen *, Chanel Keoni †, Christopher A. Waker ‡, Robert M. Lober †, ‡, §, Yi-Hsien Chen ¶, David H. Gutmann *. The publisher would like to apologize for any inconvenience caused
Letter from David Babbitt to Ralph Cameron
No full textLetter from David Babbitt supporting the establishment of a post office in the Grand Canyon National Park
Supplementary_Material – Supplemental material for Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1
No full textSupplemental material, Supplementary_Material for Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1 by Jonathan M. Payne, Kristina M. Haebich, Rachel MacKenzie, Karin S. Walsh, Stephen J. C. Hearps, David Coghill, Belinda Barton, Natalie A. Pride, Nicole J. Ullrich, James H. Tonsgard, David Viskochil, Elizabeth K. Schorry, Laura Klesse, Michael J. Fisher, David H. Gutmann, Tena Rosser, Roger J. Packer, Bruce Korf, Maria T. Acosta, Mark A. Bellgrove and Kathryn N. North in Journal of Attention Disorders</p
A quantum crystallographic approach to short hydrogen bonds
No full textIn this work we use high-resolution synchrotron X-ray diffraction for electron density mapping, in conjunction with ab initio modelling, to study short O—H⋯O and O+—H⋯O− hydrogen bonds whose behaviour is known to be tuneable by temperature. The short hydrogen bonds have donor–acceptor distances in the region of 2.45 Å and are formed in substituted urea and organic acid molecular complexes of N,N′-dimethylurea oxalic acid 2 : 1 (1), N,N-dimethylurea 2,4-dinitrobenzoate 1 : 1 (2) and N,N-dimethylurea 3,5-dinitrobenzoic acid 2 : 2 (3). From the combined analyses, these complexes are found to fall within the salt-cocrystal continuum and exhibit short hydrogen bonds that can be characterised as both strong and electrostatic (1, 3) or very strong with a significant covalent contribution (2). An additional charge assisted component is found to be important in distinguishing the relatively uncommon O—H⋯O pseudo-covalent interaction from a typical strong hydrogen bond. The electron density is found to be sensitive to the extent of static proton transfer, presenting it as a useful parameter in the study of the salt–cocrystal continuum. From complementary calculated hydrogen atom potentials, we attribute changes in proton position to the molecular environment. Calculated potentials also show zero barrier to proton migration, forming an ‘energy slide’ between the donor and acceptor atoms. The better fundamental understanding of the short hydrogen bond in the ‘zone of fluctuation’ presented in a salt-cocrystal continuum, enabled by studies like this, provide greater insight into their related properties and can have implications in the regulation of pharmaceutical materials
A defence of Mr. Garrick, in answer to the letter-writer. With remarks upon plays and players, and the present state of the stage. By a dramatic author [electronic resource].
No full textThe letter-writer = H. W., i.e. Edward Purdon, author of 'A letter to David Garrick, Esq; on opening the Theatre' published 13 October, 1759.Price from imprint: price One-Shilling.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
Cult: A Composite Novel
No full textCult (redacted)
The first component of the thesis is a composite novel called Cult which falls into two parts with seven narratives in each. Part 1 tracks the protagonist, Ellen, from her first involvement with the cult through to her eventually leaving it. Although fiction, the first half of the book answers the kinds of questions the author is asked when people discover that she was once a sannyasin (a follower of the guru Bhagwan Shree Rajneesh). While the experiences of meditation, group therapy and communal living are all faithfully rendered within the stories, the need for strong characters, narrative drive and a lightness of touch takes precedence.
Part 2 picks up Ellen’s story some twenty or so years later and explores what becomes of her in middle age. It also looks at other groups in society, such as academia, the law and the internet dating community which each have their own jargon, hierarchies, rituals and rules but are not considered to be cults.
The book examines the question raised in the Epigraph, ‘how do we be together when we feel so alone’ with a focus on relationships other than the familial and the romantic.
Collisions, Chasms and Connections: a Performative Exploration of the Composite Novel Form
The second part of the thesis is both a critical and creative response to three contemporary American books: Olive Kitteridge by Elizabeth Strout; A Visit from the Goon Squad by Jennifer Egan; and Legend of a Suicide by David Vann. The critical element comprises a close reading of the three books; a chronological reconstruction of their overarching storylines; and a consideration of what their authors have said about writing the books. It concludes that, in the composite novel, the simultaneous presentation of multiple views and storylines operate much like a 3D image to give the impression of depth to the characters and situations rendered. The creative element of the essay is a playful and personal response to the texts
Polymer multimode waveguide optical and electronic PCB manufacturing
No full textThe paper describes the research in the £1.3 million IeMRC Integrated Optical and Electronic Interconnect PCB Manufacturing (OPCB) Flagship Project in which 8 companies and 3 universities carry out collaborative research and which was formed and is technically led by the author. The consortium’s research is aimed at investigating a range of fabrication techniques, some established and some novel, for fabricating polymer multimode waveguides from several polymers, some formulations of which are being developed within the project. The challenge is to develop low cost waveguide manufacturing techniques compatible with commercial PCB manufacturing and to reduce their alignment cost. The project aims to take the first steps in making this hybrid optical waveguide and electrical copper track printed circuit board disruptive technology widely available by establishing and incorporating waveguide design rules into commercial PCB layout software and transferring the technology for fabricating such boards to a commercial PCB manufacturer. To focus the research the project is designing an optical waveguide backplane to tight realistic constraints, using commercial layout software with the new optical design rules, for a demonstrator into which 4 daughter cards are plugged, each carrying an aggregate of 80 Gb/s data so that each waveguide carries 10 Gb/s
Tslc1 (nectin-like molecule-2) is essential for spermatozoa motility and male fertility
No full textThe nectin-like molecule-2 (TSLC1) is a cell-cell adhesion molecule expressed in testicular germ cells. To directly examine the role of Tslc1 in male fertility, we generated Tslc1+/-mice that have greater than 90% reduction in Tslc1 expression. Tslc1+/- males exhibited reduced fertility and rarely transmitted the Tslc1 mutant allele, whereas Tslc1+/- females were consistently able to transmit the mutant allele. Histologic and electron microscopic analyses of the testes in Tslc1+/- mice demonstrated disruption of the junctional scaffold between germ cells and Sertoli cells. Reduced Tslc1 expression had no effect on germ cell proliferation or apoptosis. While evidence of normal spermatozoal maturation was supported by Fluorescence Activated Cell Sorting (FACS) analysis, spermatozoa from Tslc1+/- mice demonstrated markedly reduced motility without compromised viability. Collectively, these results establish an essential role for Tslc1 in spermatozoal maturation and motility, distinct from other members of the nectin family.Fil: Surace, Ezequiel Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Washington University in St. Louis; Estados UnidosFil: Strickland, Amy. Washington University in St. Louis; Estados UnidosFil: Hess, Rex A.. University of Illinois; Estados UnidosFil: Gutmann, David H.. Washington University in St. Louis; Estados UnidosFil: Naughton, Cathy K.. Washington University in St. Louis; Estados Unido
Book review of David Ellis’s Death & the Author: How D. H. Lawrence Died, and Was Remembered. Oxford: Oxford UP, 2008. 273 Pages. (Hardback, $39.95). ISBN: 978-0-19-954665-7
No full textThe article reviews the book Death & the Author: How D. H. Lawrence Died, and Was Remembered, by David Ellis
Letter from Lillian Baker, to David H. Pryor, United States Senator, June 19, 1987
No full textCopy of a letter to Arkansas Senator David H. Pryor on providing materials, including a yearbook from Manzanar, to be used in the hearing on the S1009 bill.The Japanese American Relocation Collection is composed of ephemera related to the relocation program during World War II. Items include the official government report of Manzanar Relocation Center, a photo album, post-war activism materials related to preserving and remembering the camps, various clippings, and documents. The strength of this collection is found in its many perspectives on the controversial relocation program and how it has been presented since World War II
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