1,720,977 research outputs found
Landscape Analyses Priority Tiers for All CEPI Vaccine Development Adverse Events of Special Interest (AESI) (Addendum to SO1-D2.2 & 2.3)
Get PDFThis deliverable collates into a single document all AESI lists developed as part of the Landscape Analyses for Lassa Fever/MERS and Nipah virus, Rift Valley Fever, Chikungunya and COVID-19. All AESIs are distributed into one of four timeline-related priority tiers which will serve to guide the creation of additional tools designed to facilitate AESI data collection, determine case definition level of certainty and support epidemiologic and other studies (Risk Factors, background rates, ICD9/10 and MedDRA codes).This project is funded in whole by CEPI
AESI Case Definition Companion Guide: Acute Disseminated Encephalomyelitis
No full textThis document collates into a single document all SPEAC Acute ADEM resources (Risk factors, background rates, ICD9/10-CM & MedDRA codes), tools (data abstraction & interpretation form, tabular summary of key case definition criteria and algorithm for level of certainty determination, pictorial level of certainty algorithm) and guidance (real time investigation, data collection, analysis and presentation). This guide can be used by stakeholders to assess the occurrence of Acute Disseminated Encephalomyelitis (ADEM) in several settings including as an adverse event following immunization.The SPEAC project is funded in whole by CEPI
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Second update - Priority List of Adverse Events of Special Interest: COVID-19
No full textAs part of its work to harmonize safety assessment of CEPI-funded vaccines, the Safety Platform for Emergency vACcines (SPEAC) Project has generated a list of adverse events of special interest (AESI) for safety monitoring based on one or more of the following criteria:
1) known association with immunization or a specific vaccine platform;
2) theoretical association based on animal models;
3) occurrence during wild-type disease as a result of viral replication and/or immunopathogenesis.
COVID-19 is unique as an emerging pandemic pathogen with an ever-expanding variety of clinical manifestations which might occur as presenting complaints and/or emerge during and following the course of acute disease. The first SPEAC COVID-19 AESI list was created in March 2020 based on the experience in China; it was updated in May 2020 as the global experience with the SARS-CoV-2 viral infection expanded. The May 2020 list was adopted by the WHO Global Advisory Committee on Vaccine Safety (GACVS) at their May 27-28, 2020 meeting. Subsequently, SPEAC implemented a systematic review process to ensure an ongoing understanding of the full spectrum of COVID-19 disease and modification of the AESI list accordingly. The first evidence-based update was completed in September 2020 with no AESIs added to the May 2020 list.
This document provides detailed methods and results of the December 2020 COVID-19 quarterly update. Separate annexes are included consolidating all reviews since March 2020, summarizing publication type and frequency of events, by body system. A companion excel spreadsheet has been prepared which contains the full citations with download links included in the March, May, September and December 2020 updates separated into tabs by body system. Four secondary objectives are also addressed: 1) a reassessment of the need for Brighton case definitions to be created for all the AESIs on the May 2020 list, 2) consideration of new AESIs for addition to the list, 3) consolidation of the systematic reviews presented in May, September and December 2020 and 4) consideration of the need for a change in focus of the next update due in March 2021.
Based on the findings presented in the December 2020 update SPEAC recommends the following:
1. Three new events are added to the COVID-19 AESI list: rhabdomyolysis, subacute thyroiditis and acute pancreatitis.
2. For the prior listed AESI acute kidney injury recommend use of the international criteria defined by the Kidney Disease Improving Global Outcomes (KDIGO) expert consensus group in 2012 rather than develop a new Brighton case definition.
3. For the prior listed AESI acute liver injury, adopt what has been used in many COVID-19 publications reporting elevations above the upper normal limit of >3-fold for AST/ALT and >2-fold for total bilirubin, GGT and ALP rather than develop a Brighton case definition.
4. Pending publication of the Brighton case definition on cardiovascular injury which will focus on myocarditis and pericarditis, and in-depth review of existing meta-analyses and systematic reviews, defer a decision regarding development of additional Brighton case definitions for the other entities included in cardiovascular injury (arrhythmia, acute coronary syndrome, heart failure, cardiogenic shock, stress cardiomyopathy and microangiopathy).
5. For the next COVID-19 update, due in March 2021, limit the focus to COVID-19 disease outcomes in pregnancy and childhood along with long term complications.The SPEAC Project is funded in whole by CEPI
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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