327 research outputs found
Portrayal of Woman in the Short Stories of Shashi Deshpande and Varsha Adalja: A Comparative Study
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Strategies to overcome barriers to innovative digitalisation technologies for supply chain logistics resilience during pandemic
No full textLogistics is a crucial function for any organisation. In the scenario of a pandemic or other disruptions, the role of logistics becomes even more important. Digitalisation of logistics and the supply chain is seen as an important tool for logistics resilience in such situations, but for developing countries digitalisation poses certain challenges. This study identifies barriers to innovative digitalisation technology that hinder the digital elevation of supply chain logistics during a pandemic. Strategies to deal with and overcome these barriers are proposed. The multi-criteria decision analysis method (Bayesian best-worst method) is used to prioritise such barriers within the context of the Indian logistics sector of manufacturing organisations. The strategies are also prioritised according to their impact on the barriers, for which the additive value function is used. The results show that “high cost of investment”, “lack of monetary resources”, “inadequate internet connectivity”, “lack of IT (Information Technology) infrastructure” and “unclear economic benefit of digital investment” are the top five barriers to implementing innovative digitalisation technologies in developing countries like India, during a pandemic situation. The findings reveal an insight into digitalisation barriers during a pandemic that can be of value to managers and researchers
miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity
No full textImproved therapy of cancer has significantly increased the lifespan of patients. However, cancer survivors face an increased risk of cardiovascular complications due to adverse effects of cancer therapies. The chemotherapy drug doxorubicin is well known to induce myofibril damage and cardiac atrophy. Our aim was to test potential counteracting effects of the pro-hypertrophic miR-212/132 family in doxorubicin-induced cardiotoxicity. In vitro, overexpression of the pro-hypertrophic miR-212/132 cluster in primary rodent and human iPSC-derived cardiomyocytes inhibited doxorubicin-induced toxicity. Next, a disease model of doxorubicin-induced cardiotoxicity was established in male C57BL/6N mice. Mice were administered either adeno-associated virus (AAV)9-control or AAV9-miR-212/132 to achieve myocardial overexpression of the miR-212/132 cluster. AAV9-mediated overexpression limited cardiac atrophy by increasing left ventricular mass and wall thickness, decreased doxorubicin-mediated apoptosis, and prevented myofibril damage. Based on a transcriptomic profiling we identified fat storage-inducing transmembrane protein 2 (Fitm2) as a novel target and downstream effector molecule responsible, at least in part, for the observed miR-212/132 anti-cardiotoxic effects. Overexpression of Fitm2 partially reversed the effects of miR-212/132. Overexpression of the miR-212/132 family reduces development of doxorubicin-induced cardiotoxicity and thus could be a therapeutic entry point to limit doxorubicin-mediated adverse cardiac effects
Women: Perspectives and Issues in Shashi Deshpande's A Matter of TIME and Small Remedies
No full textA noteworthy novelist and author of many children books, Shashi Deshpande, has acquired a unique place in Indian writing in English. Her novels are written in simple and lucid language. All of them deal with simple people belonging to small strata of society in general as well as predicament of women in particular in the society and family. Her women characters seem to be alive and breathing in the surrounding nearby each of us as we see in our daily life. They are ordinary women who struggle for their own identity, self-realization and emancipation. Since Indian society is adhered to patriarchal set up, as a result the traditional women in Shashi Deshpande's novels face the problem of suppression, oppression, injustice, exploitation and marginalization. Even if they are educated, they are the victims of several kinds of evils. Shashi Deshpande is much sieved to think the condition of women and fought for the cause of women. In the time of Shashi Deshpande men thought women as child-bearing machine. She tries her best to make aware her women their rights and fills them with courage in order they may demand their rights and make a niche in the society
Women: Perspectives and Issues in Shashi Deshpande’s A Matter of Time and Small Remedies
No full textA noteworthy novelist and author of many children books, Shashi Deshpande, has acquired a unique place in Indian writing in English. Her novels are written in simple and lucid language. All of them deal with simple people belonging to small strata of society in general as well as predicament of women in particular in the society and family. Her women characters seem to be alive and breathing in the surrounding nearby each of us as we see in our daily life. They are ordinary women who struggle for their own identity, self-realization and emancipation. Since Indian society is adhered to patriarchal set up, as a result the traditional women in Shashi Deshpande’s novels face the problem of suppression, oppression, injustice, exploitation and marginalization. Even if they are educated, they are the victims of several kinds of evils. Shashi Deshpande is much sieved to think the condition of women and fought for the cause of women. In the time of Shashi Deshpande men thought women as child-bearing machine. She tries her best to make aware her women their rights and fills them with courage in order they may demand their rights and make a niche in the society
Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression
No full text
Rationale:
RBPs (RNA-binding proteins) have been described to be expressed and regulated in various organs including the heart. Little is known about the role of RBPs in heart failure induced by the chemotherapy drug doxorubicin and their interaction with circular RNAs.
Objective:
We aimed to identify key RBPs involved in doxorubicin-mediated heart failure and to elucidate their function.
Methods and Results:
Global transcriptome profiling from murine myocardium exposed to doxorubicin identified 5 differentially expressed RBPs. Expression of the RBP QKI (Quaking) in response to doxorubicin was strongly downregulated in rodent cardiomyocytes and human induced pluripotent stem cell–derived cardiomyocytes in vitro and in vivo in mice. Knockdown of
Qki
in primary cardiomyocytes increased apoptosis and atrophy after treatment with doxorubicin, whereas lentiviral mediated overexpression of
Qki5
inhibited the doxorubicin-induced apoptosis in cardiomyocytes. In vivo, AAV9 (adeno-associated virus serotype 9)–mediated cardiac overexpression of
Qki5
prevented cardiac apoptosis and cardiac atrophy induced by doxorubicin and improved cardiac function. Mechanistically, by lentiviral-based overexpression and CRISPR/Cas9-mediated silencing of
Qki5
, we identified regulated expression of specific circular RNAs derived from
Ttn
(Titin),
Fhod3
(Formin homology 2 domain containing 3), and
Strn3
(Striatin, calmodulin-binding protein 3). Moreover, inhibition of
Ttn
-derived circular RNA increased the susceptibility of cardiomyocytes to doxorubicin.
Conclusions:
We here show that overexpression of
Qki5
strongly attenuates the toxic effect of doxorubicin via regulating a set of circular RNAs.
Qki5
is, thus, an interesting target molecule to combat doxorubicin-induced cardiotoxicity.
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Exploration of (Small) Remedies to Marginalization of women in Shashi Deshpande’s Small Remedies
No full textThe term ‘Marginalization’ often refers to the overt behaviour of human communities, wherein individuals or certain groups are excluded or marginalized systematically in varied ways. In many of her works, Shashi Deshpande who is a contemporary Indo-English novelist has presented the plight of middle- class women who oscillate between traditional and modern roles. Shashi Deshpande’s Small Remedies (2000) sketches a well-documented record of struggle and success, fight and frustration of her women characters particularly the female protagonist. Subjugation and suppression, as the novel depicts, has been the destiny of women. The present study explores the multifaceted ways in which women strive to battle for autonomy, self-identity, and to secure a voice of their own
Correction: Kaushik, P.; Kumar, S. Transcriptome Analysis of Bael (Aegle marmelos (L.) Corr.) a Member of Family Rutaceae. Forests 2018, 9, 450
No full textThe (Forests) Editorial Office wishes to make the following changes to the author’s paper [...
Telomerase therapy attenuates cardiotoxic effects of doxorubicin
No full textS.1395-1410Doxorubicin is one of the most potent chemotherapeutic agents. However, its clinical use is restricted due to the severe risk of cardiotoxicity, partially attributed to elevated production of reactive oxygen species (ROS). Telomerase canonically maintains telomeres during cell division but is silenced in adult hearts. In non-dividing cells such as cardiomyocytes, telomerase confers pro-survival traits, likely owing to the detoxification of ROS. Therefore, we hypothesized that pharmacological overexpression of telomerase may be used as a therapeutic strategy for the prevention of doxorubicin-induced cardiotoxicity. We used adeno-associated virus (AAV)-mediated gene therapy for long-term expression of telomerase in in vitro and in vivo models of doxorubicin-induced cardiotoxicity. Overexpression of telomerase protected the heart from doxorubicin-mediated apoptosis and rescued cardiac function, which was accompanied by preserved cardiomyocyte size. At the mechanistic level, we observed altered mitochondrial morphology and dynamics in response to telomerase expression. Complementary in vitro experiments confirmed the anti-apoptotic effects of telomerase overexpression in human induced pluripotent stem cell-derived cardiomyocytes after doxorubicin treatment. Strikingly, elevated levels of telomerase translocated to the mitochondria upon doxorubicin treatment, which helped to maintain mitochondrial function. Thus, telomerase gene therapy could be a novel preventive strategy for cardiotoxicity by chemotherapy agents such as the anthracyclines.29Nr.
On some efficient classes of estimators using auxiliary attribute
No full textThis paper considers some efficient classes of estimators for the estimation of population mean using known population proportion. The usual mean estimator, classical ratio, and regression estimators suggested by Naik and Gupta (1996) and Abd-Elfattah et al. (2010) estimators are identified as the members of the suggested class of estimators. The expressions of bias and mean square errors are derived up to first-order approximation. The proposed estimators were put to test against various other competing estimators till date. It has been found both theoretically and empirically that the suggested classes of estimators dominate the existing estimators
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