1,720,964 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Regulation of gene expression during DNA damage response in Plasmodium falciparum
No full textThe genomic integrity of Plasmodium parasite remains under constant threat from exogenous and endogenous genotoxic stresses throughout the developmental stages of the parasite complex life cycle. Here, we investigated the responses of P. falciparum to DNA damaging agents to assess its DNA repair capacity on one side and the mutational effect of DNA damage on the other. Using DNA microarrays, we have characterized a global transcriptional response of P. falciparum to methyl methanesulphonate (MMS), which alkylates DNA bases and causes strand breaks. Alongside, we studied the epigenetic regulation of DNA damage response in the parasite. Our results showed that MMS causes up-regulation of DNA repair and DNA repair-related pathways. MMS-induced gene expression is accompanied by hyperacetylation of histone lysine residues H4K8Ac, H4K16Ac and deacetylation of H3K56Ac and H3K9Ac. Intriguingly, the induction of the DNA repair machinery, initially observed in the drug susceptible parasite strains (3D7 and D6), could not be detected in two drug-resistant parasites (Dd2 and W2). Also, our genome sequencing results identified point mutations in 18 DNA repair genes that were exclusively present in Dd2 and W2. These latter strains were previously shown to exhibit a mutator phenotype also termed as accelerated resistance to multiple drugs (ARMD). Although a link between the DNA repair machinery and ARMD phenotype has been suggested previously, our results provide mechanistic evidence that the ARMD phenotype is potentially caused by a defect in a sensing/signaling pathway(s) that triggers the DNA repair machinery upon DNA damage. Further, Artemisinin, the primary antimalarial drug for P. falciparum infections, has been long debated for its mechanism of action. Here, we elucidated that MMS and artemisinin induced transcriptional up-regulation of repair machinery and altered the chromatin structure in a similar manner at multiple stages. Taken together, artemisinin elicits DNA damage response in parasite, which is similar to the MMS mediated response. Differential gene expression in Plasmodium confers flexibility to the changing environments as well as providing the parasite with indispensable tools for survival and pathogenesis. The exact mechanism of such transcriptional differences in Plasmodium gene expression is unknown. Although few focused studies on sub-telomeric virulence gene families have indicated the role of chromatin in regulating the differential gene expression. Our objective was to investigate the role of epigenetic mediated mechanism in the differential gene expression in two P. falciparum strains. By comparing the gene expression and histone modification patterns (H3K9Ac and H3K56Ac) between Dd2 and T996 strains, we found that most differentially expressed genes associated with differential H3K56 acetylation. Further, we characterized one of the AP2 domains containing transcription factor (putative), PF14_0271, which was found to be both differentially acetylated and differentially expressed between P. falciparum strains. Using endogenous tagging and knock-out approach, our results suggest that PF14_0271 is a schizont specific transcriptional regulator.DOCTOR OF PHILOSOPHY (SBS
- …
