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    Patch Solid Lipid Nanoparticles (SLN) Mengandung Ekstrak Bekatul (Oryza Sativa L.) untuk Pengobatan Diabetes Melitus Tipe 2

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    Diabetes mellitus is the increase in blood glucose level by a lack of secretion (insulin resistance) or an absence of pancreatic insulin which is one of the Non-Communicable Diseases (NCDs). 90% of existing cases are of type 2 diabetes mellitus (IDF, 2017). Type 2 diabetes, known as non-dependent-insulin occurs due to tissue resistance to the effects of insulin and the relative deficiency of insulin secretion (WHO, 2016).Type 2 diabetes mellitus is often diagnosed at a younger age and in men with lower body mass index than women. Various risk factors of diabetes are age, physical activity, body mass index (BMI), blood pressure, stress, lifestyle, family history, HDL cholesterol, triglycerides, gestational diabetes, history of glucose abnormalities and other complications. Other risk factors that may play a part are smoking and consuming alcoholic beverages (Isnaini, 2018). According to Riskesdas data in 2013, the prevalence of male smokers was 66%, which is about 10 times higher than women, which is 6.7% (Data and Information Center of the Indonesian Ministry of Health, 2013).Patients with type 2 diabetes mellitus, not only require non-pharmacological therapies such as diet regulation, physical activity, quitting smoking and alcohol, but also require pharmacological therapy that can be carried out by injecting insulin and/or taking oral antidiabetic drugs (Neal, 2012). However, insulin treatment therapy has a problem in patients who are afraid of needles and syringes, besides that, treatment with oral antidiabetic may cause several problems such as weight loss, hypoglycemia, digestive system disorders, etc. The cost of diabetes treatment is quite expensive due to long-term treatment and which may even last a lifetime. The cost needed to provide therapy to patients who have been diagnosed with diabetes worldwide from 2011 to 2030 is 1.7 trillion US(WHO,2016).Consideringthehighcostofdiabetestreatmentsandthesideeffectscausedbyantidiabeticdrugs,alternativetherapyisneededatarelativelycheaperprice,withstrongerpotencyandminimalsideeffects.Thiscanbedoneusingwasteyetitisefficaciousforthetreatmentofdiabetesmellitus,anexamplebeingricebran(Sivamaruthi,Kesika,andChaiyasut,2018).aatausekresiinsulinpankreasyangtidakbekerjadenganbaik(resistensiinsulin)dimanamenjadisalahsatuprioritaspenyakittidakmenular(noncommunicablediseases/NCDs).Darikasusdiabetesyangada,90 (WHO, 2016). Considering the high cost of diabetes treatments and the side effects caused by antidiabetic drugs, alternative therapy is needed at a relatively cheaper price, with stronger potency and minimal side effects. This can be done using waste yet it is efficacious for the treatment of diabetes mellitus, an example being rice bran (Sivamaruthi, Kesika, and Chaiyasut, 2018).a atau sekresi insulin pankreas yang tidak bekerja dengan baik (resistensi insulin) dimana menjadi salah satu prioritas penyakit tidak menular (noncommunicable diseases/NCDs). Dari kasus diabetes yang ada, 90% diantaranya merupakan diabetes melitus tipe 2 (IDF, 2017). Diabetes tipe 2 atau disebut dengan diabetes non-dependen-insulin ini terjadi karena resistensi jaringan terhadap efek insulin dan defisiensi relatif sekresi insulin (WHO, 2016).Diabetes Melitus Tipe 2 lebih sering didiagnosis pada usia yang lebih rendah dan indeks massa tubuh pada pria dibandingkan wanita. Berbagai faktor risiko diabetes adalah usia, aktivitas fisik, indeks massa tubuh (IMT), tekanan darah, stres, gaya hidup, adanya riwayat keluarga, kolesterol HDL, trigliserida, DM kehamilan, riwayat ketidaknormalan glukosa dan kelainan lainnya. Selain itu, faktor resiko yang berpengaruh adalah kebiasaan merokok dan minum minuman beralkohol (Isnaini, 2018). Berdasarkan data Riskesdas pada tahun 2013, prevalensi perokok laki-laki sebanyak 66% dimana sekitar 10 kali lebih tinggi dibandingkan perempuan yaitu sebanyak 6,7% (Pusat Data dan informasi Kementerian Kesehatan RI, 2013).Penderita diabetes melitus tipe 2, selain memerlukan terapi non-farmakologis seperti mengatur pola makan, berolahraga, tidak merokok dan tidak minum minuman beralkohol juga memerlukan terapi farmakologis yang dapat dilakukan dengan menyuntikkan insulin dan/atau meminum obat antidiabetik oral (Neal, 2012). Namun penggunaan terapi pengobatan dengan insulin memiliki masalah pada pasien yang takut dengan jarum suntik, selain itu pengobatan dengan antidiabetik oral juga memiliki beberapa masalah yaitu adanya efek samping seperti penurunan berat badan, hipoglikemia, gangguan sistem pencernaan, dan lain-lain. Biaya pengobatan diabetes sendiri cukup mahal karena pengobatannya dalam jangka panjang dan bahkan bisa seumur hidup. Biaya yang diperlukan untuk memberi terapi pada pasien yang telah terdiagnosis diabetes di seluruh dunia pada 2011 hingga 2030 sebanyak 1,7 triliun US (WHO, 2016). Mempertimbangkan biaya pengobatan diabetes yang cukup tinggi dan efek samping yang ditimbulkan oleh obat-obat antidiabetes diperlukan suatu terapi alternatif dengan harga yang relatif murah dan memiliki potensi yang kuat serta memiliki efek samping yang minimal. Hal tersebut dapat dilakukan dengan menggunakan limbah namun berkhasiat dalam terapi pengobatan diabetes melitus, diantaranya adalah bekatul (Sivamaruthi, Kesika and Chaiyasut, 2018)

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author Index

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    koamabayili/VECTRON-author-checklist: VECTRON author checklist

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    We have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used

    Author Under Sail The Imagination of Jack London, 1893-1902

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    In Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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