1,616 research outputs found
Cut-elimination, substitution and normalisation
No full textDate of Acceptance: 01/2015We present a proof (of the main parts of which there is a formal version, checked with the Isabelle proof assistant) that, for a G3-style calculus covering all of intuitionistic zero-order logic, with an associated term calculus, and with a particular strongly normalising and confluent system of cut-reduction rules, every reduction step has, as its natural deduction translation, a sequence of zero or more reduction steps (detour reductions, permutation reductions or simplifications). This complements and (we believe) clarifies earlier work by (e.g.) Zucker and Pottinger on a question raised in 1971 by Kreisel.Peer reviewe
I remember teaching English at Seabrook
No full textIn this "I remember" memoir, Isabell Waugh, a former teacher at Seabrook, compares and constrasts the different groups of students she taught. She remembers that native-born American teenagers tended to be more concerned with athletics and social activities, than academic matters. In comparison, Estonian and Japanese parents did not tolerate low academic performance, so students from the two groups often competed intensely with each other for academic achievement and recognition. Isabelle recalls that the Estonians were, in general, more sophisticated and better educated. Most of the children knew 3-5 languages, and were more advanced in math and science. She sensed that some Estonian parents felt that their homes at Seabrook were temporary, and that they would be returning to Estonia at some point. The Seabrook Educational and Cultural Center has been soliciting current and past residents of Seabrook Farms for an "I remember" project. Residents are asked to create narratives regarding their experiences at Seabrook Farms. These memories help preserve the history and multi-cultural heritage of Seabrook Farms
Isabelle Bell to Susan Niemcewicz, December 23, 1800
No full textIsabelle Bell wrote to Susan U. Niemcewicz in Elizabethtown, New Jersey. Bell expressed her disappointment in not receiving a line from Susan. She sent Bell Lucretia Rephans subscription epistle, but Susan refrained from writing a letter to her. Bell did not execute any of Susan’s commissions in New York because her time there was short. Miss Resham heard that Mr. B Livingston told his sister, Mrs. J. Livingston that he would offer Bell a salary to live in his house and take charge of his children’s education. Asked if Susan what she thought of her being an author and if Susan would subscribe to a small volume that may have the good fortune to rival the poems of the immortal Scarron.https://digitalcommons.kean.edu/lhc_1800s/1143/thumbnail.jp
Interviews with Carl T. Bode, Isabelle Fritschen, Joseph H. Hirt, Mary G. Hirt, and Minnie Campbell
No full textInterviews with Carl T. Bode, Isabelle Fritschen, Joseph H. Hirt, Mary G. Hirt, and Minnie Campbell. The recording includes a variety of German-language songs. The last half of the recording is dedicated to Minnie Campbell telling about her time working for Mother Bickerdyke. The first few minutes of the recording are missing. 00:00:13 - Song, The Messenger Bird sung by Joseph H. Hirt and translated by Isabelle Fritschen 00:01:35 - Song, Birdie in the Window, sung by Mary Gertrude Hirt 00:02:59 - Story of Peter John Thielen\u27s experience in the Franco-Prussian War told by Joseph Hirt 00:05:27 - Grandfather\u27s experience with wild cattle told by Isabelle Fritschen 00:07:31 - Carl T. Bode introduction 00:08:46 - Nursery rhyme about hands 00:09:09 - The Cuckoo and the Donkey 00:09:42 - Sleep Baby Sleep 00:10:24 - Golden Evening Sun 00:11:00 - Beautiful Moon 00:12:10 - My Homeland 00:13:50 - Minnie Campbell Introduction 00:14:05 - Experiences as Mother Bickerdyke\u27s secretary 00:14:35 - Mother Bickerdyke\u27s 81st birthday celebration in Bunker Hill, KS 00:19:59 - Mother Bickerdyke\u27s portrait 00:23:55 - How Lydia Foster, Mother Bickerdyke\u27s Black maid came to live with her. 00:26:34 - Mother Bickerdyke\u27s death 00:29:34 - Mother Bickerdyke\u27s burial in Galesburg, Illinois 00:30:28 - Working for Mother Bickerdyke 00:34:01 - Going to School as a student of James Bickerdyke, Mother Bickerdyke\u27s son 00:35:26 - Decline of Bunker Hill, KS 00:37:15 - Russell stealing the county seat from Bunker Hill 00:38:09 - Closing of the Dorrance, KS bank 00:39:00 - Mother Bickerdyke\u27s personality 00:42:34 - Experience with Nina Brown Baker author of Cyclone in Calico 00:48:24 - Mother Bickerdyke Home for Widows and Children in Ellsworth, KS 00:51:13 - Post scripthttps://scholars.fhsu.edu/sackett/1014/thumbnail.jp
Formalization of Isabelle Meta Logic in NuPRL
No full textNuPRL and Isabelle are two general purpose theorem provers. Both of them are based on a version of Constructive Higher Order Type Theory. In an earlier work the author has proposed an informal semantics of Isabelle Meta Logic in an extension of NuPRL Type Theory. An automated converter, based on this semantics, has been developed, that translates Isabelle theorem statements into NuPRL. This work presents a formalization of the above semantics in NuPRL. It starts with a deep embedding of Isabelle type and term syntax into NuPRL Constructive Type Theory. Next, two internal NuPRL functions are defined. One of them maps Isabelle types into NuPRL types and the other maps Isabelle terms into elements of appropriate NuPRL types. These two functions provide an interpretation of Isabelle in NuPRL. Finally, interpretations of all Isabelle Meta Logic rules are proven as theorems in some classical extension of NuPRL Type Theory. This formalization is aimed to provide a more secure foundation for the interaction between two systems
Impact de la température corporelle sur la phosphorylation de tau dans le contexte du sommeil
No full textLa protéine tau est un marqueur pathologique important de la maladie d’Alzheimer car son niveau de phosphorylation et d’agrégation sont en corrélation avec la progression de la maladie. Les troubles du sommeil sont fréquents dans la maladie d'Alzheimer et inversement les études longitudinales montrent que les personnes présentant des troubles du sommeil sont plus à risque de développer la maladie d’Alzheimer. Cependant, on ne sait pas par quels mécanismes le manque de sommeil contribue au développement de la maladie. Mon laboratoire d’accueil à précédemment démontré que la température centrale peut affecter la phosphorylation de la protéine tau et que la température corporelle suit des oscillations circadiennes, nous avons émis l'hypothèse que la phosphorylation de la protéine tau pourrait être soumise à des oscillations circadiennes dues à la température corporelle. L’objectif de cette thèse était de déterminer si la phosphorylation de tau suit un rythme circadien et si la température corporelle et le sommeil sont impliqués dans le processus. Dans un premier temps, nous avons montré que la phosphorylation de tau suit un rythme circadien : lorsque les animaux dorment, leur température est plus basse et la protéine tau est plus phosphorylée, inversement, pendant l’activité, la température corporelle est plus haute, et tau est déphosphorylée. Pour déterminer si la température corporelle est directement impliquée dans le rythme circadien de la phosphorylation de tau, nous avons modifié les oscillations circadiennes de la température corporelle en exposant les animaux à 34ºC dans une étuve prévue à cet effet. L’exposition des animaux à cette température diminuait l’amplitude de la variation circadienne de la température corporelle et annulait les variations circadiennes de la phosphorylation de tau. Par la suite, nous avons déterminé si le sommeil pouvait avoir un impact sur la température corporelle et sur phosphorylation de tau en privant des souris de sommeil pendant 6 heures. La privation de sommeil augmentait la température corporelle et diminuait significativement la phosphorylation de tau. Pour vérifier que la température corporelle est impliquée dans le rythme circadien de la phosphorylation de tau nous avons exposé une lignée de cellules neuronales à la température rectale moyenne mesurée chez les souris pendant le sommeil (36.3ºC) et l’activité (37.4ºC). Une baisse de la température d’un degré était suffisante pour diminuer significativement la phosphorylation de tau. Globalement, nos résultats démontrent que la phosphorylation de la protéine tau suit un iv rythme circadien et qu’elle est influencée par le cycle veille/sommeil et par la température corporelle.Tau protein is an important pathological marker of Alzheimer's disease because its level of phosphorylation and aggregation correlates with the progression of the disease. Sleep disorders are common in Alzheimer's disease and conversely longitudinal studies show that people with sleep disorders are at higher risk to develop Alzheimer's disease. However, the mechanisms by which poor sleep contributes to the development of the disease are unknown. As my host laboratory previously demonstrated that central body temperature can affect the phosphorylation of tau protein and that body temperature follows circadian oscillations, we hypothesized that phosphorylation of tau protein could be subjected to circadian oscillations due to body temperature. The objective of this thesis was to determine if phosphorylation of tau follows a circadian rhythm and if body temperature and sleep are involved in the process. First, we showed that the phosphorylation of tau follows a circadian rhythm: when the animals were sleeping, their temperature was lower and tau protein was more phosphorylated, conversely, during the activity, body temperature was higher, and tau was dephosphorylated. To determine whether body temperature was involved in the circadian rhythm of tau phosphorylation, we changed the circadian body temperature oscillations by exposing the animals to 34ºC in an incubator dedicated for animal housing. Exposure to 34ºC decreased the magnitude of circadian body temperature variation and abolished circadian changes in tau phosphorylation. Subsequently, we determined whether sleep had an impact on body temperature and tau phosphorylation by testing the effect of 6 hours sleep deprivation. Sleep deprivation increased body temperature and significantly decreased tau phosphorylation. To verify that body temperature is directly involved in circadian rhythm of phosphorylation of tau, we exposed a neuronal cell line at the mean rectal temperature measured during sleep (36.3ºC) and activity (37.4ºC). A decrease of one degree Celsius was sufficient to significantly decrease tau phosphorylation. Overall, our results demonstrate that phosphorylation of tau protein follows a circadian rhythm and is influenced by the sleep/wake cycle and body temperature
Security modeling and correctness proof using Specware and Isabelle
No full textSecurity modeling is the foundation to formal verification which is a core requirement for high assurance systems. This thesis explores how security models can be built in a simple and expressive manner using the Metaslang specification language in Specware. The models are subsequently translated, via the Specware to Isabelle Interface, to be proven for correctness in Isabelle which is a generic, interactive theorem proving environment. It is found that the translation between Specware and Isabelle is almost seamless and there is much potential in the use of Isabelle/HOL to discharge proof obligations that arise in developing Specware specifications, although the actual proving requires substantial knowledge and experience in logical calculus.Approved for public release; distribution is unlimited.Outstanding ThesisSingapore ST Electronics Ltd. author (civilian).http://archive.org/details/securitymodeling10945383
Isabelle/DOF: Design and Implementation
No full textThis is the author accepted manuscript. The final version is available from Springer Verlag via the DOI in this record17th International Conference, SEFM 2019
Oslo, Norway, September 18–20, 2019DOF is a novel framework for defining ontologies and enforcing them during document development and evolution. A major goal of DOF is the integrated development of formal certification documents (e. g., for Common Criteria or CENELEC 50128) that require consistency across both formal and informal arguments. To support a consistent development of formal and informal parts of a document, we provide Isabelle/DOF, an implementation of DOF on top of the formal methods framework Isabelle/HOL. A particular emphasis is put on a deep integration into Isabelleâs IDE, which allows for smooth ontology development as well as immediate ontological feedback during the editing of a document. In this paper, we give an in-depth presentation of the design concepts of DOFâs Ontology Definition Language (ODL) and key aspects of the technology of its implementation. Isabelle/DOF is the first ontology language supporting machine-checked links between the formal and informal parts in an LCF-style interactive theorem proving environment. Sufficiently annotated, large documents can easily be developed collabo- ratively, while ensuring their consistency, and the impact of changes (in the formal and the semi-formal content) is tracked automatically.IRT SystemX, Paris-Saclay, Franc
La construction d'un monde professionnel : entrées des jeunes praticiens dans la médecine générale
No full textIsabelle Baszanger
The young general practitioners in the medical field.
Using interviews with young medical doctors (general practitioners) the author studies the ways they organize their empirical practice (as opposed to theoretical knowledge) and constructs a typology which caracterizes specific modes of professionnal socialization. This leads the author to evaluate the social dimensions of the role of general practitioners.La socialisation professionnelle des étudiants en médecine implique la formation d'un univers conceptuel qui est une sorte de compromis entre le savoir médical et la pratique quotidienne. A partir d'entretiens avec de jeunes médecins généralistes l'auteur a étudié comment les jeunes médecins organisent leur pratique et construit une typologie reflétant ces mécanismes particuliers de socialisation.
Cette analyse conduit l'auteur à s'interroger sur la dimension sociale du rôle du médecin généraliste telle qu'il la perçoit.Baszanger Isabelle. La construction d'un monde professionnel : entrées des jeunes praticiens dans la médecine générale. In: Sociologie du travail, 25ᵉ année n°3, Juillet-septembre 1983. pp. 275-294
Imperial Performativity: the Life, Transgressions, and Writings of Isabelle Eberhardt under the Lens of Queer Theory
No full textAn examination of Isabelle Eberhardt\u27s life and writings with regard to gender norms and imperialist expectations in French-controlled Algeria. The PDF includes the author\u27s entry submission essay for the 2011 Undergraduate Research Awards
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