336 research outputs found
Rétrotransposons et cellules somatiques
No full textLes éléments transposables sont des séquences d’ADN endogènes mobiles constituant environ 40 % du génome humain. D’abord reconnus comme actifs dans les cellules germinales adultes, il apparaît qu’ils ont aussi une activité de transposition élevée dans les cellules somatiques. Leur implication directe dans les mécanismes oncogéniques s’avère cruciale dans la dérégulation de l’expression génique normale. De nouveaux mécanismes de régulation de leur expression ont été découverts montrant que leur silencing, par l’intermédiaire de modifications épigénétiques, dépend de gènes suppresseurs de tumeur
particleShear: Discrete Python particle simulation with digital rheology and stress tensor evaluation
No full textparticleShear: Python package for particle shear simulation
This package provides a discrete particle simulation kit for having multiple spheres interacting. The spheres (i.e. 2D circles) interact by mutual elastic repulsion and tangential friction upon contact, but can also be crosslinked together. In addition to the elementary implementation of the interacting particles, it is also possible to define rheological experiments where the spheres are exposed to sinusoidally varying displacement conditions on the boundaries. We paid particular attention to avoid pitfalls that generate asymmetric stress tensors.
Acknowledgement: Thanks from the author go to Fabien Bonini and Joé Brefie-Guth for package testing, and to Daniel Lyobenov for initial help with simulation setup.
This repository archives the releases of the source code hosted at https://github.com/tbgitoo/particleShear. The package is available through the Python package server (see https://pypi.org/project/particleShear/1.0.2/). It can be installed automatically in python via
pip3 install particleShear
In some installations, the command may also be pip install particleShear; the minimal version of Python is 3.
Optimizing construction of scheduled data flow graph for on-line testability
No full textThe objective of this work is to develop a new methodology for behavioural synthesis using a flow of synthesis, better suited to the scheduling of independent calculations and non-concurrent online testing. The traditional behavioural synthesis process can be defined as the compilation of an algorithmic specification into an architecture composed of a data path and a controller. This stream of synthesis generally involves scheduling, resource allocation, generation of the data path and controller synthesis. Experiments showed that optimization started at the high level synthesis improves the performance of the result, yet the current tools do not offer synthesis optimizations that from the RTL level. This justifies the development of an optimization methodology which takes effect from the behavioural specification and accompanying the synthesis process in its various stages. In this paper we propose the use of algebraic properties (commutativity, associativity and distributivity) to transform readable mathematical formulas of algorithmic specifications into mathematical formulas evaluated efficiently. This will effectively reduce the execution time of scheduling calculations and increase the possibilities of testability
Dataset: Stability of hemicarbonate under cement paste-like conditions
No full textData, and scripts (analysis, plots) to go with the publication:
Stability of hemicarbonate under cement paste-like conditions
Fabien Georget (a,1,∗), Barbara Lothenbach (b) , William Wilson (a,c) , Franco Zunino (a) Karen L. Scrivener (a)
a: aboratory of Construction Materials, LMC, EPFL-STI-IMX, Station 12, CH-1015
Lausanne, Switzerland
b: Empa, Concrete & Asphalt Laboratory, Dübendorf, Switzerland
c: Sherbrooke University, Sherbrooke, Quebec, Canada
1: current address: Institute of Building Materials Research, RWTH Aachen, Aachen, Germany
* corresponding author
To be submitted to Cement and Concrete Researc
Histone deacetylase 9
No full textThe identification and cloning of histone deacetylase 9 (HDAC9) is disclosed, and in particular full length HDAC9 polypeptides and HDAC9 polypeptides which have deacetylase activity, and to nucleic acid molecules encoding these polypeptides. The uses of these polypeptides and nucleic acid molecules are disclosed, for example for screening for compounds that are capable of modulating a HDAC9 biological activity
Author Correction: A molecular timescale for eukaryote evolution with implications for the origin of red algal-derived plastids
No full textVagabondage dans Le Mont Damion d’André Dhôtel
No full textThe paper discusses the theme of wandering in the novel by French author André Dhôtel. The protagonist of Le Mont Damion, Fabien Gort, is not a typical vagrant, as he is a member of an intellectual and quite rich family. However, because of his strong absent-mindedness and strangeness, Fabien is unable to find a place in social structures. People’s hostility leads him to many wanderings and unexpected encounters which influence his existence. The novel seems to be also a generic wandering, as it possesses some features of picaresque novel, adventure novel, initiation story and fairytale fantasy
Early-life and chronic exposure to high-fat diet alters noradrenergic and glutamatergic neurotransmission in the male rat amygdala and hippocampus under cognitive challenges
No full textOBEETEEN Consortium: Guillaume Ferreira, Gustavo Pacheco-Lopez, Etienne Coutureau, Ranier Gutierrez, Pascal Barat, Federico Bermudez-Rattoni, Gwenaelle Catheline, Claudia I. Pérez,, Pauline Lafenêtre, Daniel Osorio-Gomez, Kioko Guzman-Ramos, Fabien Naneix, Ernesto Sanz-Arigita, Ioannis Bakoyiannis. Note: Consortium author list recognizes the significant and irreducible commitment with the conceptualization, management, and realization of this research project.Peer reviewe
The geology of the Ste. Justine map-area.
No full textFollowing the discovery of copper-nickel mineralization in 1951 at St. Fabien de Panet, Montmagny County, about 50 miles east of Quebec City, the Quebec Department of Mines initiated a program of geological mapping in this area. In 1952, the author assisted Dr. J. Beland in the mapping of the St. Magloire area where the copper-nickel mineralization was discovered. [...
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