1,666 research outputs found
Delle relationi vniuersali di Giouanni Botero Benese : parte seconda.
No full textEl ed. figura en banderilla, debajo se lee: "ad istanza"Imp. tomado de Colofón en h. [14] v.: "In Roma, appresso Guglielmo Faciotto, M.D. XCII"Sign.: *\p2\s, A-Z\p4\s, 2A-2O\p4\sPort. con grab. xi
Un classicista barocco e il suo pubblico: Ottavio Ferrari (1607-1682) tra umanesimo e antiquaria
No full textIl rilancio dei classici e dei Padri
No full textThe place of classical and patristic texts in the works of XIVth and XVth-century authors is investigate
Tracing the Origin, Spread, and Molecular Evolution of Dengue Type 1 Cases That Occurred in Northern Italy in 2023
No full textThe dengue virus (DENV) is a mosquito-borne flavivirus endemic to many tropical and subtropical regions. Over the past few decades, the global incidence of dengue has risen dramatically, with the virus now present in over 100 countries, putting nearly half of the world’s population at risk. This increase is attributed to several factors, including urbanization, climate change, and global travel, which facilitate the spread of both the virus and its mosquito vectors. While dengue is primarily associated with tropical regions, outbreaks in temperate areas are becoming increasingly common due to the spread of Aedes albopictus, a competent vector for DENV that can adapt to cooler climates. This study investigates the molecular dynamics and geographic evolution of DENV type 1 (DENV-1) strains isolated from 13 patients during an autochthonous outbreak in Lombardy, Northern Italy, between August and September 2023. Additionally, Aedes albopictus mosquitoes were collected from a neighboring area to assess their potential role in the outbreak. A metagenomic approach was used to recover DENV-1 consensus sequences from clinical samples. Genotype classification and phylogenetic analyses were performed using Bayesian methods and a comprehensive dataset of DENV-1 sequences from other countries. The Italian autochthonous strains clustered with South American strains collected between 2020 and 2023, specifically those belonging to genotype V, subtype D. Bayesian analysis estimated a mean evolutionary substitution rate of 8.234 × 10−4 substitutions per site per year (95% HPD interval: 7.1448 × 10−4–9.3343 × 10−4), with the time to the most recent common ancestor (tMRCA) dating back to 1972 (95% HPD interval: 1968–1976). These findings suggest the likely introduction of the virus into the region from endemic areas in South America, followed by local transmission. This study offers valuable insights into the dynamics of the DENV-1 outbreak in Lombardy, underscoring the importance of genomic surveillance in monitoring viral spread and evolution. The findings emphasize the critical need for enhanced molecular and entomological surveillance to detect and respond to emerging autochthonous DENV cases in temperate regions where competent vectors, such as Aedes albopictus, are present. Public health strategies should prioritize integrated vector management, real-time genomic monitoring, and awareness campaigns to mitigate the risk of future outbreaks. These measures are essential to address the growing threat posed by the geographic expansion of the dengue virus
Gli studi classici a Padova nel XVII e XVIII secolo: Ottavio Ferrari e Jacopo Facciolati
No full textAppunti per la città del poco futuro
No full textLa società occidentale sta invecchiando. In Europa, l'Italia sta invecchiando più delle altre nazioni e Genova ha gli indici di invecchiamento più alti: qui i bambini sono sempre meno, i giovani si allontanano e gli anziani sono molti di più, lo sono più a lungo e lo sono entro strutture sociali che non li assorbono più nel corpo di famiglie multiformi e numerose. La speranza di vita per le donne occidentali è di 84,8 anni, per gli uomini di 79,3: solo 50 anni fa era rispettivamente di 72,3 e 67,2 .
Se la terza o quarta età sono oggetto di studi, al centro delle preoccupazioni delle istituzioni e delle mire del mercato per il giro di affari potenziale, appare ancora fuori fuoco la riflessione sulle implicazioni che la vecchiaia ha sulla città, sui suoi spazi, sulla sua organizzazione. E i sempre più diffusi studi specifici su questi aspetti non riescono ad uscire da un approccio che oscilla tra il tecnicismo e la generalità.
Intorno a questo tema sembra mancare una visione di ampio respiro come quelle che solo le avanguardie artistiche e il pensiero utopico sono riusciti a proporre.
Platone, Campanella, Thomas More, Charles Owen, Étienne Cabet, per citare alcuni casi noti, hanno re-inventato la società secondo principi di giustizia, equità e modelli organizzativi e spaziali rivoluzionari. Un analogo afflato prospettico, fiducioso e idealista ha alimentato altre visioni del futuro altrettanto utopiche: dalle architetture "radicali" italiane a quelle di Archigram e dei Metabolisti, alle utopie geografiche di Herbert Sörgel a quelle ecologiste di Ernest Callenbach.
In tutti i casi, l'uomo al centro dell'utopia è sempre sano, nel pieno delle energie, della maturità e delle sue capacità produttive e riproduttive.
Cosa succede dunque se invece proviamo a mettere al centro di un'utopia un idealtipico uomo anziano? Un uomo, o una donna, che ha oltrepassato la soglia dei 65 anni, che deve fare i conti con una condizione di debolezza o di malattia? E soprattutto cosa significa costruire una visione urbana per una città dedicata e costruita su misura per questo genere di persone?
"Appunti per la città del poco futuro" è un lavoro in itinere che chi scrive ha avviato in occasione di una recente mostra presso la galleria d'arte Pinksummer a Genova che prova a dare risposta a queste domande a partire dalle constatazioni sopra citate, usando il pensiero utopico come sponda.
Il paper illustra i contenuti del lavoro e ne restituisce in maniera critica alcuni nodi
Portrait of the Author in (Him/Her)self
No full textA fragment of a philosophical essay by Jean-Luc Nancy and Federico Ferrari titled Iconographie dell’auteur (Paris, 2005), published for the first time in Polish, that addresses the problem of a relationship between the image of the author and his/her work
The impact of PET imaging on triple negative breast cancer: an updated evidence-based perspective
No full textIntroductionTriple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by the absence of estrogen, progesterone, and HER2 receptors. It predominantly affects younger women and is associated with a poor prognosis. This systematic review aims to evaluate the current role of positron emission tomography (PET) in the management of TNBC patients and to identify future research directions.MethodsWe systematically searched the PubMed, Scopus, and Web of Science databases up to February 2024. A team of five researchers conducted data extraction and analysis. The quality of the selected studies was assessed using a specific evaluation form.ResultsTwenty-eight studies involving 2870 TNBC patients were included in the review. Key clinical applications of PET in TNBC included predicting pathological complete response (pCR) in patients undergoing neoadjuvant chemotherapy (NAC), assessing the prognostic value of baseline PET, and initial disease staging. Two studies utilized PSMA-ligand agents, while the majority used [18F]FDG-based PET. Significant associations were found between baseline [18F]FDG uptake and molecular biomarkers such as PDL-1, androgen receptor, and Ki67. Baseline [18F]FDG PET led to the upstaging of patients from stage IIB to stage IV, influencing treatment decisions and survival outcomes. In the NAC setting, serial PET scans measuring changes in [18F]FDG uptake, indicated by maximum standardized uptake value (SUVmax), predicted pCR with varying cut-off values correlated with different response rates. Semiquantitative parameters such as metabolic tumor volume (MTV) and PET lung index were prognostic for metastatic disease.ConclusionsIn TNBC patients, [18F]FDG PET is essential for initial disease staging in both localized and metastatic settings. It is also useful for assessing treatment response to NAC. The ability of PET to correlate metabolic activity with molecular markers and predict treatment outcomes highlights its potential in TNBC management. Further prospective studies are needed to refine these clinical indications and establish its definitive role
Requirements elicitation and refinement in collaborative research projects
No full textEuropean Union (EU) projects are means of the European Commission for funding research activities. Such projects address challenging research objectives by involving both academic and industrial partners, from several countries. Information and communication technologies–related projects often undertake to deliver a software system prototype. In such a context, most of the typical issues of global requirements engineering may emerge. Partners can have different background and expertise, needs are not sharply defined, and communication is hampered by linguistic and cultural differences. If these issues are not carefully taken into account from the beginning, problems frequently emerge during project execution. This paper presents the experience of applying a customized elicitation and refinement approach in the context of the Learn PAd EU project, which involved about 50 people. The approach combines collaborative elicitation and wiki-based refinement sessions to come to a set of consolidated requirements. Lessons learnt are discussed as a guidance for researchers dealing with analogous issues in similar contexts. Some of the major observations refer to the importance of initial face-to-face meetings when combined with asynchronous remote interactions; the role of moderators that have to encourage collaboration and foster a shared understanding; and the definition of guidelines to select wiki-based platforms
The impact of PET imaging on triple negative breast cancer: an updated evidence-based perspective.
No full textintroduction: triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by the absence of estrogen, progesterone, and HER2 receptors. It predominantly affects younger women and is associated with a poor prognosis. this systematic review aims to evaluate the current role of positron emission tomography (PET) in the management of TNBC patients and to identify future research directions.
methods: we systematically searched the pubmed, scopus, and web of science databases up to february 2024. a team of five researchers conducted data extraction and analysis. the quality of the selected studies was assessed using a specific evaluation form.
results: twenty-eight studies involving 2870 TNBC patients were included in the review. key clinical applications of PET in TNBC included predicting pathological complete response (pCR) in patients undergoing neoadjuvant chemotherapy (NAC), assessing the prognostic value of baseline PET, and initial disease staging. two studies utilized PSMA-ligand agents, while the majority used [18F]FDG-based PET. significant associations were found between baseline [18F]FDG uptake and molecular biomarkers such as PDL-1, androgen receptor, and Ki67. baseline [18F]FDG PET led to the upstaging of patients from stage IIB to stage IV, influencing treatment decisions and survival outcomes. In the NAC setting, serial PET scans measuring changes in [18F]FDG uptake, indicated by maximum standardized uptake value (SUVmax), predicted pCR with varying cut-off values correlated with different response rates. semiquantitative parameters such as metabolic tumor volume (MTV) and PET lung index were prognostic for metastatic disease.
conclusions: In TNBC patients, [18F]FDG PET is essential for initial disease staging in both localized and metastatic settings. It is also useful for assessing treatment response to NAC. the ability of PET to correlate metabolic activity with molecular markers and predict treatment outcomes highlights its potential in TNBC management. further prospective studies are needed to refine these clinical indications and establish its definitive role
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