1,720,988 research outputs found
Goodman & Gilman. Le basi farmacologiche della terapia. Con espansione online. Capitolo Chemioterapia della tubercolosi, delle malattie da Mycobacterium avium complex e della lebbra.
No full text
Decadimento cognitivo.
No full textImpiego delle piante medicinali nella cura delle patologie del decadimento cognitivo sulla base delle evidenze cliniche
Wikipedia in teaching "Pharmacology and Pharmacotherapy" to Pharmacy students
No full textWikipedia is a very popular website on the Internet, free of any charge and written by spontaneous
editors; each voice is checked and continuously modified by anyone who has the skills to do it. To increase the
motivation in learning Pharmacology of fourth year students of Pharmacy degree, it has been proposed to them to
participate in drafting several Wikipedia entries regarding selected drugs among those treated during frontal
teaching lessons. The Wiki groups started their work at the end of October and finished it in January 2019. Overall,
students learned to reformulate knowledge on the drugs, to work in group, to consult various types of sources
(databases, articles, texts) and to use a language suitable for inexperienced readers
Ansia e Insonnia.
No full textImpiego delle piante medicinali nella cura dei disturbi del sonno e dell'ansia in base alle evidenze cliniche
What could be the better choice between ACE inhibitors and AT1R antagonists in coronavirus disease 2019 (COVID-19) patients?
No full textAngiotensin-converting enzyme 2 (ACE2) removes a single residue from Ang I to yield Ang (1-9) and cleaves a single residue from Ang II to generate Ang (1-7). Thus ACE2 counterbalances ACE function decreasing Ang II levels1 . Consequently, this enzyme has a protective role against excessively high blood pressure values and high level of renin-angiotensin system (RAS) activation2 . This article is protected by copyright. All rights reserved
The Use of Medicinal Plants in Blood Vessel Diseases: The Influence of Gender
Full text linkData available in the literature on the use of herbal products to treat inflammation-related vascular diseases were considered in this study, while also assessing the influence of gender. To this end, the articles published in PubMed over the past 10 years that described the use of plant extracts in randomized clinical trials studying the effectiveness in vascular pathologies were analyzed. The difference in efficacy of plant-derived preparations in female and male subjects was always considered when reporting. The safety profiles of the selected plants were described, reporting unwanted effects in humans and also by searching the WHO database (VigiBase®). The medicinal plants considered were Allium sativum, Campomanesia xanthocarpa, Sechium edule, Terminalia chebula. Additionally, an innovative type of preparation consisting of plant-derived nanovesicles was also reported
View on Metformin: Antidiabetic and Pleiotropic Effects, Pharmacokinetics, Side Effects, and Sex-Related Differences
Full text linkMetformin is a synthetic biguanide used as an antidiabetic drug in type 2 diabetes mellitus,
achieved by studying the bioactive metabolites of Galega officinalis L. It is also used off-label for various
other diseases, such as subclinical diabetes, obesity, polycystic ovary syndrome, etc. In addition,
metformin is proposed as an add-on therapy for several conditions, including autoimmune diseases,
neurodegenerative diseases, and cancer. Although metformin has been used for many decades, it
is still the subject of many pharmacodynamic and pharmacokinetic studies in light of its extensive
use. Metformin acts at the mitochondrial level by inhibiting the respiratory chain, thus increasing
the AMP/ATP ratio and, subsequently, activating the AMP-activated protein kinase. However,
several other mechanisms have been proposed, including binding to presenilin enhancer 2, increasing
GLP1 release, and modification of microRNA expression. Regarding its pharmacokinetics, after oral
administration, metformin is absorbed, distributed, and eliminated, mainly through the renal route,
using transporters for cationic solutes, since it exists as an ionic molecule at physiological pH. In this
review, particular consideration has been paid to literature data from the last 10 years, deepening the
study of clinical trials inherent to new uses of metformin, the differences in effectiveness and safety
observed between the sexes, and the unwanted side effects. For this last objective, metformin safety
was also evaluated using both VigiBase and EudraVigilance, respectively, the WHO and European
databases o
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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