1,720,954 research outputs found
High-sensitivity troponin I for risk stratification in normotensive pulmonary embolism
No full textWhile numerous studies have confirmed the prognostic role of high-sensitivity troponin T (hsTnT) in pulmonary embolism (PE), high-sensitivity troponin I (hsTnI) is inappropriately studied. This study aimed to investigate the prognostic relevance of hsTnI in normotensive PE, establish the optimal cut-off value for risk stratification and to compare the prognostic performances of hsTnI and hsTnT. Based on data from 459 consecutive PE patients enrolled in a single-centre registry, receiver operating characteristic analysis was used to identify an optimal hsTnI cut-off value for prediction of in-hospital adverse outcomes (PE-related death, cardiopulmonary resuscitation or vasopressor treatment) and all-cause mortality. Patients who suffered an in-hospital adverse outcome (4.8%) had higher hsTnI concentrations compared with those with a favourable clinical course (57 (interquartile range (IQR) 22–197) versus 15 (IQR 10–86) pg·mL −1 , p=0.03). A hsTnI cut-off value of 16 ng·mL −1 provided optimal prognostic performance and predicted in-hospital adverse outcomes (OR 6.5, 95% CI 1.9–22.4) and all-cause mortality (OR 3.7, 95% CI 1.0–13.3). Between female and male patients, no relevant differences in hsTnI concentrations (17 (IQR 10–97) versus 17 (IQR 10–92) pg·mL −1 , p=0.79) or optimised cut-off values were observed. Risk stratification according to the 2019 European Society of Cardiology algorithm revealed no differences if calculated based on either hsTnI or hsTnT (p=0.68). Our findings confirm the prognostic role of hsTnI in normotensive PE. HsTnI concentrations >16 pg·mL −1 predicted in-hospital adverse outcome and all-cause mortality; sex-specific cut-off values do not seem necessary. Importantly, our results suggest that hsTnI and hsTnT can be used interchangeably for risk stratification
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Prognostische Bedeutung von hochsensitivem Troponin I bei normotensiven Patienten mit akuter Lungenembolie
Full text linkIn der vorliegenden Arbeit wurde die prognostische Bedeutung von hochsensitivem Troponin I bei normotensiven Patienten mit akuter Lungenembolie untersucht. Ziel war es einen optimierten Grenzwert für hochsensitives Troponin I für die Risikostratifizierung zu identifizieren und die diagnostische Qualität des Grenzwerts zu untersuchen. Außerdem untersuchten wir mögliche geschlechtsabhängige Unterschiede der prognostischen Bedeutung von hochsensitivem Troponin I. Abschließend verglichen wir die prognostische Bedeutung von hochsensitivem Troponin I mit hochsensitivem Troponin T.
Patienten, die im Zeitraum von September 2008 bis einschließlich April 2018 in das Pulmonary Embolism Registry Göttingen aufgenommen wurden, wurden in die Studie eingeschlossen. Alle Patienten wurden in der Universitätsmedizin Göttingen behandelt und waren zum Zeitpunkt des Studieneinschlusses volljährig. Es lag von allen Patienten eine schriftliche Einwilligungserklärung vor.
Hoch-Risiko-Patienten nach der Definition der aktuell gültigen Leitlinie der European Society of Cardiology aus 2019 wurden aus der Studie ausgeschlossen. Außerdem wurden Patienten mit einer schweren akuten kardio-pulmonalen Erkrankung als primäre Ursache für die aktuelle Symptomatik genauso wie Patienten mit fehlenden Messwerten von hochsensitivem Troponin I ausgeschlossen. Die zum Zeitpunkt der Aufnahme gemessenen Plasmakonzentrationen von hochsensitivem Troponin I (ARCHITECT stat hsTnI assay, Abbott Laboratories, Chigago, IL, USA) wurden nach einmaligem Auftauen der Proben in einer Charge bestimmt.
Insgesamt wurden 459 normotensive Patienten (241 Frauen, 218 Männer; medianes Alter 69 Jahre) mit akuter Lungenembolie in die Studie eingeschlossen. Mittels Receiver operating characteristics-Analyse konnten wir einen optimierten Grenzwert für hochsensitives Troponin I für Komplikationen während des Krankenhausaufenthalts (d.h. kardiopulmonale Reanimation, Katecholamintherapie, Lungenembolie-bedingter Tod) in Höhe von 16 pg/ml etablieren.
Patienten mit Komplikationen (4,8%) während des Krankenhausaufenthaltes wiesen signifikant höhere Konzentrationen von hochsensitivem Troponin I als Patienten ohne Komplikationen auf (57 pg/ml IQA: 22-197 versus 15 pg/ml IQA: 10-86; p=0.030). Der optimierte Grenzwert in Höhe von 16 pg/ml war mit einer OR von 6,5 (95% KI: 1,9-22,4) für Komplikationen während des Krankenhausaufenthalts und einer OR von 3,7 (95% KI: 1,0-13,3) für die Krankenhausmortalität assoziiert. Die Konzentrationen von hochsensitivem Troponin I (17 pg/ml für Frauen (IQA: 10–97) versus 17 pg/ml für Männer (IQA: 10–92) p=0.79) als auch ein optimierter Grenzwert (17 pg/ml für Frauen und 19 pg/ml für Männer) ergaben keine relevanten geschlechtsabhängigen Unterschiede. Die Berechnung von Algorithmen zur Risikostratifizierung ergab keine Unterschiede im prognostischen Wert der Ergebnisse zwischen hochsensitivem Troponin T und I (p=0,68).
Insgesamt belegen unsere Studienergebnisse die prognostische Bedeutung von hochsensitivem Troponin I bei normotensiven Patienten mit akuter Lungenembolie. Der optimierte Grenzwert in Höhe von 16pg/ml ist ein geeignetes prognostisches Mittel, um Komplikationen während des Krankenhausaufenthalts sowie die Krankenhausmortalität vorherzusagen. Geschlechtsabhängige Unterschiede und Grenzwerte erscheinen nicht notwendig. Es zeigte sich, dass hochsensitives Troponin I und T beide gleichwertig im Rahmen der Risikostratifzierung von normotensiven Patienten mit akuter Lungenembolie eingesetzt werden können.This study investigated the prognostic significance of high-sensitivity troponin I (hsTnI) in normotensive patients with acute pulmonary embolism (PE). The goal was to identify an optimized cutoff value for hsTnI for risk stratification and assess its diagnostic quality. Additionally, the study explored potential sex-based differences in the prognostic value of hsTnI and compared it to high-sensitivity troponin T (hsTnT).
Patients enrolled in the Pulmonary Embolism Registry Göttingen from September 2008 to April 2018 were included, provided they were adults, treated at the University Medicine Göttingen, and had given written consent. High-risk patients as defined by the 2019 European Society of Cardiology guidelines, patients with severe acute cardio-pulmonary conditions as the primary cause of symptoms, and patients without hsTnI measurements were excluded.
The study included 459 normotensive patients (241 women, 218 men; median age 69 years) with acute PE. The hsTnI plasma concentrations were determined using the ARCHITECT stat hsTnI assay. The receiver operating characteristic analysis established an optimized hsTnI cutoff of 16 pg/ml for predicting complications during hospitalization (i.e., cardiopulmonary resuscitation, catecholamine therapy, PE-related death). Patients with complications (4.8%) had significantly higher hsTnI levels than those without complications (57 pg/ml IQA: 22-197 vs. 15 pg/ml IQA: 10-86; p=0.030). The optimized cutoff was associated with an odds ratio (OR) of 6.5 (95% CI: 1.9-22.4) for complications and an OR of 3.7 (95% CI: 1.0-13.3) for hospital mortality. No significant sex-based differences in hsTnI levels or the optimized cutoff were found (17 pg/ml for women vs. 17 pg/ml for men, p=0.79).
Risk stratification algorithms showed no difference in the prognostic value between hsTnI and hsTnT (p=0.68). The findings confirm the prognostic importance of hsTnI in normotensive patients with acute PE. The optimized cutoff of 16 pg/ml is a reliable predictor of complications and hospital mortality. Sex-specific differences and varying cutoffs do not seem necessary. Both hsTnI and hsTnT can be used equivalently for risk stratification in normotensive patients with acute PE.2025-06-1
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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