178,176 research outputs found
New genetic insights highlight 'old' ideas on motor dysfunction in dystonia
No full textPrimary dystonia is a poorly understood but common movement disorder. Recently, several new primary dystonia genes were identified that provide new insight into dystonia pathogenesis. The GNAL dystonia gene is central for striatal responses to dopamine (DA) and is a component of a molecular pathway already implicated in DOPA-responsive dystonia (DRD). Furthermore, this pathway is also dysfunctional and pathogenically linked to mTOR signaling in L-DOPA-induced dyskinesias (LID). These new data suggest that striatal DA responses are central to primary dystonia, even when symptoms do not benefit from DA therapies. Here we integrate these new findings with current understanding of striatal microcircuitry and other dystonia-causing insults to develop new ideas on the pathophysiology of this incapacitating movement disorder.sponsorship: We would like to acknowledge COST (European Cooperation in Science and Technology) Action BM1101 for facilitating discussion and promoting networking. The authors also acknowledge financial support from the Foundation for Dystonia Research (FDR) to R.G., K.G., A.P., the Dystonia Medical Research Foundation (DMRF) to A.P. and previous support of KG. and R.G., and the Italian Ministry of Health (Progetto Finalizzato) to A.P. KG. received funding from the Deutsche Forschungsgemeinschaft, the IZKF programme of the University of Tuebingen and the Elitepostdoc programme Baden-Wiirttemberg. (Foundation for Dystonia Research (FDR), Dystonia Medical Research Foundation (DMRF), Italian Ministry of Health (Progetto Finalizzato), Deutsche Forschungsgemeinschaft, IZKF programme of the University of Tuebingen, Elitepostdoc programme Baden-Wiirttemberg)status: Publishe
First Person Authority
No full textGrundmann T, Spitzley T, Stoecker R, eds. First Person Authority. Erkenntnis, 71,1. Berlin u.a.: Springer; 2009
Sozialisation der Emotionen - enacted
No full textSchützeichel R. Sozialisation der Emotionen - enacted. In: Grundmann M, Höppner G, eds. Dazwischen - Sozialisationstheorien reloaded. Weinheim: Beltz Juventa; 2020: 244-270
Handlungen, Absichten und der Nebeneffekt-Effekt
No full textStoecker R. Handlungen, Absichten und der Nebeneffekt-Effekt. In: Grundmann T, Horvath J, Kipper J, eds. Die experimentelle Philosophie in der Diskussion. Suhrkamp-Taschenbuch Wissenschaft. Vol 2094. Berlin: Suhrkamp; 2014: 259-278
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Systemtheorie und Subjektbildung. Eine Diskussion neuer Perspektiven am Beispiel des Verhältnisses von Selbstsozialisation und Ko-Konstruktion
No full textSutter T. Systemtheorie und Subjektbildung. Eine Diskussion neuer Perspektiven am Beispiel des Verhältnisses von Selbstsozialisation und Ko-Konstruktion. In: Grundmann M, Beer R, eds. Subjekttheorien interdisziplinär. Diskussionsbeiträge aus Sozialwissenschaften, Philosophie und Neurowissenschaften. Individuum und Gesellschaft: Beiträge zur Sozialisations- und Gemeinschaftsforschung, 1. Münster: LIT-Verlag; 2004: 155-183
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Unusual Course of the Reaction of Allyl Phosphine Oxides with the Grundmann Ketone
No full text<div><p></p><p>This article describes efficient preparation of isomeric allyl phosphine oxides possessing a protected cyclohexanediol fragment. Their base-catalyzed interconversions are examined and reactions with the Grundmann ketone provide an adduct containing the rearranged vinyl phosphine oxide moiety, instead of 19-norvitamin D<sub>3</sub> analogs, the expected products of the Horner–Wittig process.</p>
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Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Letter from R. R. Zellick, Assistant Trust Officer, Anglo California National Bank of San Francisco, to Joseph R. Goodman, October 2, 1942
No full textLetter from R. R. Zellick, Assistant Trust Officer at The Anglo California National Bank of San Francisco, to Joseph R. Goodman, regarding property owned by Dave Tatsuno. Zellick mentions a dispute between current tenants and Tatsuno, and that Tatsuno has asked Goodman to help locate trustworthy tenants.Personal correspondence, organizational records, government documents, publications, and other papers created or collected by Joseph R. Goodman documenting the forced removal and incarceration of Japanese Americans during World War II, as well as organized resistance to incarceration. Included in the collection are records of the Japanese Young Men's Christian Association and the Japanese American Citizens' League in San Francisco, including papers of the Japanese YMCA's executive secretary Lincoln Kanai; Sakai family papers; Goodman's correspondence to and from Japanese American incarcerees, organizations opposing forced removal and incarceration of Japanese Americans, the War Relocation Authority, and others; publications, photographs, and ephemera from the Topaz Relocation Center, where Goodman taught high school; War Relocation Authority records and publications; and newspaper clippings, pamphlets, and reports about forced removal and incarceration created by various government, religious, and civic organizations, in California and nationwide
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