14,850 research outputs found
Effect of ketogenic mediterranean diet with phytoextracts and low carbohydrates/high-protein meals on weight, cardiovascular risk factors, body composition and diet compliance in Italian council employees
No full textAbstract Background There has been increased interest in recent years in very low carbohydrate ketogenic diets (VLCKD) that, even though they are much discussed and often opposed, have undoubtedly been shown to be effective, at least in the short to medium term, as a tool to tackle obesity, hyperlipidemia and some cardiovascular risk factors. For this reason the ketogenic diet represents an interesting option but unfortunately suffers from a low compliance. The aim of this pilot study is to ascertain the safety and effects of a modified ketogenic diet that utilizes ingredients which are low in carbohydrates but are formulated to simulate its aspect and taste and also contain phytoextracts to add beneficial effects of important vegetable components. Methods The study group consisted of 106 Rome council employees with a body mass index of ≥ 25, age between 18 and 65 years (19 male and 87 female; mean age 48.49 ± 10.3). We investigated the effects of a modified ketogenic diet based on green vegetables, olive oil, fish and meat plus dishes composed of high quality protein and virtually zero carbohydrate but which mimic their taste, with the addition of some herbal extracts (KEMEPHY ketogenic Mediterranean with phytoextracts). Calories in the diet were unlimited. Measurements were taken before and after 6 weeks of diet. Results There were no significant changes in BUN, ALT, AST, GGT and blood creatinine. We detected a significant (p 2 to 29.01 Kg/m2), body weight (86.15 kg to 79.43 Kg), percentage of fat mass (41.24% to 34.99%), waist circumference (106.56 cm to 97.10 cm), total cholesterol (204 mg/dl to 181 mg/dl), LDLc (150 mg/dl to 136 mg/dl), triglycerides (119 mg/dl to 93 mg/dl) and blood glucose (96 mg/dl to 91 mg/dl). There was a significant (p Conclusions The KEMEPHY diet lead to weight reduction, improvements in cardiovascular risk markers, reduction in waist circumference and showed good compliance.</p
The Ketogenic Diet and Sport: A Possible Marriage?
No full textThe ketogenic diet (KD) is used widely as a weight loss strategy and, more rarely, as therapy for some diseases. In many sports, weight control is often necessary (boxing, weightlifting, wrestling, etc.), but the KD usually is not considered. Our hypothesis is that KD might be used to achieve fat loss without affecting strength/power performance negatively
Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets.
No full textA Framework to Select Techniques Supporting Project Risk Management
No full textThe need for increasing quality while reducing time and costs asks for developing knowledge about how to manage risk in projects. However, communication and knowledge creation are not easy tasks, especially when dealing with uncertainty, because decision-making is often fragmented and a shared perspective on the goals, opportunities, and threats of a project is missing. With the purpose of stimulating knowledge, a framework to classify techniques supporting project risk management is proposed. To this end, three dimensions encompassing the main aspects characterising the managerial and operational scenario of a project are considered: the phases of the risk management process, the phases of the project life cycle, and the corporate maturity towards risk. The taxonomy is then applied to a wide selection of risk techniques based on the analysis of literature and the authors' experience. Future research efforts will be directed towards refining the framework and testing it in multiple industrie
Long term successful weight loss with a combination biphasic ketogenic mediterranean diet and mediterranean diet maintenance protocol
No full textWeight loss protocols can only be considered successful if they deliver consistent results over the long term-a goal which is often elusive, so much so that the term "yo-yo" is used to describe the perennial weight loss/weight regain battle common in obesity. We hypothesized that a ketogenic Mediterranean diet with phytoextracts (KEMEPHY) combined with the acknowledged health benefits of traditional Mediterranean nutrition may favor long term weight loss. We analysed 89 male and female obese subjects, aged between 25 and 65 years who were overall healthy apart from being overweight. The subjects followed a staged diet protocol over a period of 12 months: 20 day of KEMEPHY; 20 days low carb-non ketogenic; 4 months Mediterranean normocaloric nutrition; a second 20 day ketogenic phase followed by 6 months of Mediterranean normocaloric nutrition. For the majority of subjects (88.25%) there was significant loss of weight (from 100.7 ± 16.54 to 84.59 ± 9.71 kg; BMI from 35.42 ± 4.11 to 30.27 ± 3.58) and body fat (form 43.44% ± 6.34% to 33.63% ± 7.6%) during both ketogenic phases followed by successful maintenance, without weight regain, during the 6 month stabilization phase with only 8 subjects failing to comply. There were also significant and stable decreases in total cholesterol, LDLc, triglycerides and glucose levels over the 12 month study period. HDLc showed small increases after the ketogenic phases but over the full 12 months there was no significant change. No significant changes were observed in ALT, AST, Creatinine or BUN. The combination of a biphasic KEMEPHY diet separated by longer periods of maintenance nutrition, based on the traditional Mediterranean diet, led to successful long term weight loss and improvements in health risk factors in a majority of subjects; compliance was very high which was a key determinant of the results seen
Una interpretación de a-ka-na-jo ( a3-ka-na-jo)
No full textThe author studies the word a-ka-na-jo in the PY Cn 328 tablet and taking into account some factors she proposes αγναιος as the reading of this word.The author studies the word a-ka-na-jo in the PY Cn 328 tablet and taking into account some factors she proposes αγναιος as the reading of this word
Environmental influences over the last 16 ka on compound-specific δ13C variations of leaf wax n-alkanes in the Hani peat deposit from northeast China
No full textCompound-specific carbon isotope ratios (δ13C) of leaf wax n-alkanes (C21-C33 odd carbon numbered n-alkanes) were measured in the Hani peat sequence from northeast China. These data were compared with lipid biomarker compositions to assess changes in local vegetation and paleoclimate for the last 16 ka The δ13C values of n-alkanes range between -36.6 and -30.7‰, showing that the compounds originate from C3 plants. Much larger variations (∼5.4‰) in the n-alkane δ13C values than those of atmospheric CO2 during the last 16 ka (< 0.5‰) indicate that the isotopic values were affected by environmental factors in addition to the postglacial δ13C variations in the atmospheric reservoir. The stratigraphic records of δ13C reveal decoupled fluctuations among the individual n-alkanes, particularly between 15.5 to 11.4 ka. Synchronous excursions in the δ13C offsets among individual n-alkanes (Δδ13C) and lipid biomarker paleoplant proxies (Paq, and C23/C31 and C27/C31) from 14.9 to 13.2 ka and 12.7 to 11.6 ka suggest that vegetational changes are the most likely causes for the decoupled δ13C variations. Parallel fluctuations of the δ13C values of terrestrial higher plant-derived C29 and C31 n-alkanes and the n-alkane average chain-length (ACL) from 11 to 6 ka indicate that the δ13C variations responded to net evaporation changes. Negative shifts in the n-alkane δ13C values coinciding with the ACL decreases at 10.5-9.3 ka and 8.1 ka indicate the short-term onset and fluctuations of the summer monsoon strength in eastern China during the early Holocene
NRF2 and chemoprevention: signaling, epigenetics and role in intestinal carcinogensis
No full textPrevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage. Chemoprevention becomes an increasing important concept and has led to the intense research about the mechanisms of actions of various chemopreventive compounds. They can be generally classified into blocking agents and suppressing agents. The chemopreventive compounds usually prevent or slow progression of cancer by maintaining a low oxidative stress and inflammatory environment in cells. This is brought about by the activation of Nrf2, the key protein being investigated in our lab. In this dissertation, I will be discussing the use of compounds as suppressing agents and blocking agents, how compounds activates Nrf2 signaling, how novel Nrf2 interaction partner IQGAP1 mediates Nrf2-Keap1 signaling axis, how expression level of Nrf2 could be regulated epigenetically, apart from the well-known post-translational control by Keap1-Ubiquitinase-Protesome axis and finally how loss of Nrf2 could enhance intestinal tumorigenesis in Apc(min/+) mice.Ph.D.Includes bibliographical referencesIncludes vitaby Ka Lung Cheun
Nearby fibroblasts' response to multiple acupuncture needle revolutions on fibroblast populated collagen gels
No full textAcupuncture is an ancient Chinese healing practice, and an alternative therapy for alleviating pain and chronic disorders. For over twenty years, research is trying to understand the mechanisms that lead to its therapeutic effect. Our laboratory investigates the cellular and molecular events in the connective tissue that occur by acupuncture needling. An in vitro assay was developed to evaluate some of the potential contributors to acupuncture’s effects using a cellular collagen gel as a loose connective tissue mimic. It was hypothesized besides immediate changes to cells under mechanical loading from an acupuncture needle, there were chemical factors released to nearby cells in acupuncture. This thesis investigates whether mechanically stimulating collagen gels with fibroblasts at different revolutions would release chemical factors to nearby fibroblasts where flow cytometry was used to observe cell proliferation as an indicator. Results reveal mechanically stimulating cellular collagen gels at different revolutions does not cause any changes in cell proliferation to nearby cells. However, dead stained mechanically stimulated cellular collagen gels showed cell death occurs around the acupuncture needle. It is possible there were no effects in cell proliferation because when a cellular collagen gel was needle manipulated, some chemical factors were released into the nearby cells. Then as needle manipulation increased, more chemical factors were released, but restricted by the larger amount of cell death around the needle from the increasing rotation.M.S.Includes bibliographical referencesby Ka Po Ch
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