190 research outputs found
Physical and psychological symptoms of quality of life in the CHART randomized trial in head and neck cancer: short-term and long-term patient reported symptoms. CHART Steering Committee. Continuous hyperfractionated accelerated radiotherapy
No full textThe randomized multicentre trial of continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in patients with advanced head and neck cancer showed no good evidence of a difference in any of the major clinical outcomes of survival, freedom from metastases, loco-regional control and disease-free survival. Therefore an assessment of the effect of treatment on physical and psychological symptoms is vital to balance the costs and benefits of the two treatments. A total of 615 patients were asked to complete a Rotterdam Symptom Checklist and the Hospital Anxiety and Depression Scale, which cover a variety of physical and psychological symptoms, at a total of ten time points. The data consisted of short-term data (the initial 3 months) and long-term data (1 and 2 years). The short-term data was split into an exploratory data set and a confirmatory data set, and analysed using subject-specific and group-based methods. Differences were only claimed if hypotheses generated in the exploratory data set were confirmed in the confirmatory data set. The long-term data was not split into two data sets and was analysed using a group-based approach. There was evidence of significantly worse symptoms of pain at day 21 in those treated with CHART and significantly worse symptoms of cough and hoarseness at 6 weeks in those treated conventionally. There was also evidence to suggest a higher degree of decreased sexual interest at 1 year and sore muscles at 2 years in those treated with conventional radiotherapy. There is no clear indication that one regimen is superior to the other in terms of 'quality of life', generally the initially more severe reaction in the CHART group being offset by the longer duration of symptoms in the conventionally treated group.</p
A phase II trial of continuous 5-fluorouracil in recurrent or metastatic transitional cell carcinoma of the urinary tract
No full textAIMS: To assess the activity of a continuous infusion of 5-fluorouracil in patients with recurrent locally advanced or metastatic transitional cell carcinoma of the urinary tract.MATERIALS AND METHODS: Eight centres within the UK entered 50 patients into the study. Twenty-four weeks of continuously infused 5-fluorouracil, 300mg/m(2)/day through a mini-pump, were planned. The primary outcome was tumour response at 8 weeks after the start of treatment.RESULTS: The median age of the patients was 68 years and 37 (80.4%) had a World Health Organization performance status of 0 or 1. The overall response rate at 8 weeks, according to the response evaluation criteria in solid tumors (RECIST) criteria in 46 evaluable patients, was 15% (95% confidence interval 5-26%) and 20% (95% confidence interval 8-31%) when assessments at all time points were included. The median progression-free survival was 1.9 months (95% confidence interval 1.8-2.7 months) and the median overall survival was 6.5 months (95% confidence interval 4.1-8.5 months). The most frequent grade 3/4 toxicities were mucositis and diarrhoea (each in 6.5% of patients) and nausea/vomiting and hand-foot syndrome (each in 4.3% of patients).CONCLUSIONS: Continuous infusional 5-fluorouracil has activity in transitional cell carcinoma of the urinary tract. Prolonged fluoropyrimidine administration may be a useful component of future combination regimens for this disease, particularly in patients with poor renal function.</p
A randomized trial of radical radiotherapy for the management of pT1G3 NXM0 transitional cell carcinoma of the bladder
No full textPURPOSE: We conducted a multicenter randomized trial in the United Kingdom to determine the efficacy of radical radiotherapy in reducing the incidence of progression of pT1G3 transitional cell carcinoma of the bladder to muscle invasive disease and subsequent disease fatality.MATERIALS AND METHODS: Patients with a new diagnosis of pT1G3 NXM0 transitional cell carcinoma with unifocal disease and no carcinoma in situ (group 1), or with multifocal disease and/or carcinoma in situ (group 2) were eligible for the trial. Patients in group 1 were randomized between observation and radiotherapy to the bladder, and in group 2 between intravesical therapy and radiotherapy.RESULTS: From September 1991 to February 2003 a total of 210 patients from 37 centers in the United Kingdom were entered into the study. There were 77 patients in group 1 and 133 patients in group 2, and 6 patients were excluded from analysis because they were found to have pT2 disease by the reference pathologist. No evidence of an advantage with radiotherapy was found in terms of progression-free interval (hazard ratio 1.07; 95% CI 0.65, 1.74; p = 0.785), progression-free survival (hazard ratio 1.35; 95% CI 0.92, 1.98; p = 0.133) or overall survival (hazard ratio 1.32; 95% CI 0.86, 2.04; p = 0.193).CONCLUSIONS: To our knowledge this is the largest randomized trial performed in patients with pT1G3 disease for which 210 patients were recruited during 11 years. There is no evidence that radiotherapy is better than more conservative treatment. The prognosis of this group of patients appears to be poor irrespective of treatment and new treatment strategies need to be investigated.</p
Dependence and risk spillovers among clean cryptocurrencies prices and media environmental attention
No full textThis paper examines the relationships among cryptocurrency environmental attention and clean cryptocurrencies prices using Time-Varying Parameter Vector Auto-Regression (TVP-VAR) and wavelets techniques. Results show strong connectedness among these variables, implying that the prices of clean cryptocurrencies are influenced by attention on cryptocurrency sustainability. Connectedness is stronger with positive shocks on environmental attention than negative shocks. Also, in the short-term, clean cryptocurrencies prices lead environmental attention, especially after 2021. However, there are notable periods when environmental attention led clean cryptocurrency prices before 2021. In the long-term, clean cryptocurrencies such as Hedera, Polygon, Cosmos, IOTA, TRON, Stellar, Tezos and Ripple lead environmental attention. In the presence of bitcoin, the degrees of connectedness increased across both shocks on cryptocurrency environmental attention. In all cases, the bitcoin market is the main destination of shocks from the system. We highlight some crucial implications of these results.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Economics of Technology and Innovatio
Body length, dry and ash-free dry weights, and developmental changes at each copepodid stage in five sympatric mesopelagic aetideid copepods in the western Arctic Ocean
No full textAetideid copepods dominate the mesopelagic layer of the Arctic Ocean and play an important role in the vertical material flux and biodiversity. However, little information about the lengths and weights of their copepodids is available. In this study, we collected five sympatric aetideid copepods, Chiridius obtusifrons Sars G.O., 1902, Gaetanus tenuispinus (Sars G.O., 1900), Gaetanus brevispinus (Sars G.O., 1900), Aetideopsis multiserrata (Wolfenden, 1904), and Aetideopsis rostrata Sars G.O., 1903, from the Arctic Ocean and examined their body lengths, dry and ash-free dry weights, and developmental growths at each copepodid stage. Highly significant length-weight relationships were obtained among copepodids for all species. Within genera, individuals of the same length were heavier at shallower depths. This may result from the greater nutritional availability to species within genera inhabiting shallower depths. Common to all species, the organic content (ash -free dry weight per dry weight) was high for the early copepodid stages. This may be due to the residual organic content of lipid-rich eggs retained in the non-feeding nauplii. The largest growth in females occurred at C5/C6, whereas the largest growth in males occurred at C4/C5, as determined by moult increment and proportion of growth in weight. These sex differences in weight growth could be due to the degeneration of the feeding appendage and cessation of feeding in C6 males of aetideid copepods
Theoretical studies of the historical development of the accounting discipline: a review and evidence
No full textMany existing studies of the development of accounting thought have either been atheoretical or have adopted Kuhn's model of scientific growth. The limitations of this 35-year-old model are discussed. Four different general neo-Kuhnian models of scholarly knowledge development are reviewed and compared with reference to an analytical matrix. The models are found to be mutually consistent, with each focusing on a different aspect of development. A composite model is proposed. Based on a hand-crafted database, author co-citation analysis is used to map empirically the entire literature structure of the accounting discipline during two consecutive time periods, 1972–81 and 1982–90. The changing structure of the accounting literature is interpreted using the proposed composite model of scholarly knowledge development
Dynamic dependence and predictability between volume and return of Non-Fungible Tokens (NFTs): The roles of market factors and geopolitical risks
No full textWe examine the dependence between volume and returns for the NFT market and three sub-markets (Cryptokitties, Cryptopunks, and Decentraland) using both quantile cross-spectral coherency and quantile regression techniques. Results from both techniques show significant evidence of dependence between NFT return and volume. Dependence between volume and return is weakest in the Cryptopunks market. Similarly, quantile regression results show that during extreme market conditions, equity and gold markets uncertainty, business condition and term-spread are important predictors of Cryptokitties returns, while oil, equity and gold markets uncertainty and geopolitical risks significantly predict Cryptopunks and Decentraland markets returns. In all cases, increase in Bitcoin prices reduces NFT market returns.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Economics of Technology and Innovatio
Life extension in protective coatings via self-healing technology
No full textAs the field of self-healing materials continues to grow, novel self-healing concepts and chemistries are being developed for a variety of applications including coatings. Self-healing functionality is typically considered for incorporation in coatings to solve two basic challenges including restoration of aesthetic properties and restoration of protective function. In this talk I will compare these challenges and discuss the capability of existing technologies to meet them. I will then discuss examples of the development and application of self-healing chemistries to protective coatings and the level of success achieved in autonomic repair of coatings that have been damaged via a variety of mechanisms. These examples will include a range of laboratory and commercial formulations evaluated with a target of real world deployment in the near future
Green Transition Efficiency in African Countries: The role of climate aid and climate readiness
No full textThis research is designed to provide a structured and comprehensive examination of the complex relationship between climate readiness, climate aid, and carbon efficiency in African countries. At its heart, the primary goal is to construct a climate readiness framework initially designed to assess developing nations and subsequently refine it to align with the distinct contexts of African nations. This framework undergoes a two-fold process, starting with its conceptualization and followed by its adaptation through a combination of theoretical examination and real-world application. It forms the foundation of this research, supplying essential insights relevant to policymakers and institutions engaged in tackling climate-related issues specific to Africa.In the second phase of the study, a linear regression model is employed to analyze the connections between carbon efficiency, climate readiness, and climate aid. Carbon efficiency is determined using Data Envelopment Analysis (DEA), while the climate readiness variable is derived from the developed framework. The empirical findings underscore the critical role of targeted climate aid, particularly in countries with higher climate preparedness. This synergy contributes significantly to decoupling carbon emissions from economic growth, emphasizing the importance of strategic climate aid in fostering sustainable and environmentally responsible economic development.Overall, this research aims to shed light on the complex interplay of factors shaping climate outcomes in African countries, providing a foundation for informed decision-making and policy development in the realm of climate change mitigation and adaptation.Management of Technology (MoT
Luoghi della migrazione e corpi della tradizione. Aggravanti e attenuanti culturali in materia di modificazioni dei genitali femminili
No full textThe law prohibiting the female genital mutilation was passed by the Ital- ian Parliament in 2006 (Law 7/2006). This article presents an anthropological review about Law 7/2006 and its application. First of all, the author reviews the ambiguous use of the term “mutilation”. Then, she reconstructs the case of a Nigerian woman, G.O., arrested in Verona for allegedly having performed the “mutilation” of a three-month-old girl. Police tracked down G.O. near Verona, apparently en route to carry out the same surgery on a two-week old baby. In the first instance, the process led to the condemnation of G.O and of the parents, guilty of mutilating their daughters. On appeal, this ruling was overturned be- cause of the non-existence of specific intent to injure the body of the child
- …
