1,338 research outputs found
The Trial of Giordano Bruno
No full textIn 1600, Giordano Bruno, one of the leading intellectuals of the Renaissance, was burned at the stake on the charge of heresy by the Roman Inquisition. He is remembered primarily for his cosmological theories, particularly that the universe was infinite with the Earth not being at its centre. Today, he has become a symbol of the struggle for religious and philosophical tolerance.
The Trial of Giordano Bruno, originally published in Italian in 2018, provides English audiences with a complete and updated reconstruction of the inquisitorial trial by analysing the accusations, witnesses, and legal proceedings in detail. The author also gives a detailed profile of Bruno as well as the body which arrested and accused him – the Inquisition.
This book will appeal to all those interested in the life and death of Giordano Bruno, as well as those interested in Early Modern legal proceedings, the Roman Inquisition, and the history of religious and philosophical tolerance
Successful First-Line Treatment With Propranolol Of Multifocal Infantile Hepatic Hemangioma With High Flow Cardiac Overload
No full textA successful first-line treatment with propranolol of multifocal infantile hepatic hemangioma with high-flow cardiac overload is describe
Autoradiographic localization of putative melatonin receptors in the brain of two old world primates: Cercopithecus aethiops and Papio ursinus
No full textAbstract
The distribution of putative melatonin receptors in the brains of two Old World primates of the superfamily Catarrhina, Cercopithecus aethiops and Papio ursinus, was characterized using 2-[125I]iodomelatonin autoradiography. The specific binding demonstrated a discrete distribution pattern. The median eminence was intensely labelled, and examination at the light microscopic level demonstrated that the binding was confined to the small layer of cells comprising the pars tuberalis of the pituitary gland. The collar of pars distalis, present in the baboon (Papio ursinus), was diffusely labelled. No binding was detected in the pars distalis proper or the neural lobe of the pituitary gland. The binding in the suprachiasmatic nuclei was weaker, but well discernible. Diffuse faint specific binding was found in the frontal cortex and the dentate gyrus of the hippocampus. Two non-neural sites expressed strong, well-delineated binding: the walls of some brain blood vessels (the vertebral and spinal arteries, the inferior cerebellar and acoustic arteries, the basilar, pericallosal, internal carotid arteries, the arteries forming the circle of Willis) and the choroid plexuses. Binding in the arteries of the circle of Willis, the pars tuberalis and the suprachiasmatic nuclei was readily displaceable. Addition of 1 microM unlabelled 2-iodomelatonin following 45 min of preincubation with the radioactive ligand completely abrogated the binding. Co-incubation with guanosine 5'-O-(3-thiotriphosphate) led to a significant decrease in the apparent binding density in the pars tuberalis and abolished binding in the suprachiasmatic nuclei, but was without effect on the binding in the walls of the adjacent arteries, forming the circle of Willis, in the cortex and in the hippocampus. This qualitative distribution pattern demonstrates that in the two primate species studied, melatonin high-affinity, G-protein-linked binding sites are present in the pars tuberalis and the hypothalamic suprachiasmatic nuclei, and that melatonin may be acting as a synchronizer of the endogenous pacemakers' circadian activity, apart from its possible reproductive effects at the level of pars tuberalis, where the highest receptor density was observed. The strongly labelled arterial walls, and the flimsy labelled cortex and hippocampus, expressed different characteristics: though the binding was readily reversible, it was apparently not regulated by a guanine nucleotide-binding protein
Diagnosis of sclerosing cholangitis in children: Blinded, comparative study of magnetic resonance versus endoscopic cholangiography
No full textBackground: Magnetic resonance cholangiography (MRC) has been validated as comparable to endoscopic retrograde cholangiography (ERC) for the diagnosis of sclerosing cholangitis (SC) in adult patients. In children, MRC is widely used based mainly on non-comparative studies. Patients and methods: ERCs and MRCs of seven children (median age 9, range: 7-20. years) with SC and 17 controls (median age 6, range: 2. months-20. years) with other chronic liver diseases were reviewed in a blinded, random and independent way. All patients underwent both examinations within a 6-months slot. All ERCs and 17 MRCs were performed under general anesthesia. One radiologist evaluated both ERCs and MRCs and one interventional endoscopist independently reviewed only ERCs. Reviewers did not receive any clinical information. Diagnosis of SC, established on the basis of history, laboratory data, radiological examinations and clinical course, was used as gold standard to compare ERC and MRC diagnostic accuracy. Results: Overall image quality was graded as very good in 57% of MRC and in 71% of ERC cases; difference was not statistically significant (P= 0.24) although the probability for MRC to be diagnostic increased with patient's age. Depiction of first, second and fourth-order intrahepatic bile duct was better in ERC (P= 0.004, 0.02 and 0.023, respectively); depiction of the extrahepatic bile duct was comparable (P= 0.052). Diagnostic accuracy of MRC and ERC was very high, without statistically significant difference (P= 0.61). Conclusion: Despite an overall better depiction of the biliary tree by ERC, MRC is comparable for the diagnosis of SC in children. These data support MRC as the first imaging approach in children with suspected SC. © 2013 Elsevier Masson SAS
Blinded comparative study of magnetic resonance cholangiography versus endoscopic retrograde cholangiography in the diagnosis of sclerosing cholangitis in children.
No full textPurification and molecular characterization of a novel protein factor from Phytophthora cactorum causing toxicity in plant
No full textPediatric liver transplantation
No full textIn previous decades, pediatric liver transplantation has become a state-of-the-art operation with excellent success and limited mortality. Graft and patient survival have continued to improve as a result of improvements in medical, surgical and anesthetic management, organ availability, immunosuppression, and identification and treatment of postoperative complications. The utilization of split-liver grafts and living-related donors has provided more organs for pediatric patients. Newer immunosuppression regimens, including induction therapy, have had a significant impact on graft and patient survival. Future developments of pediatric liver transplantation will deal with long-term follow-up, with prevention of immunosuppression-related complications and promotion of as normal growth as possible. This review describes the state-of-the-art in pediatric liver transplantation
The Iron Age in Merv Oasis
No full textIn this short article the author in the volume devoted to the joint Italian/Russian/Turkmenian activities in south Turkmenistan entitled Archaeological Map of the Murghab delta is dealing with the development of the Iron Age in Central Asia. In particular the author is dealing with the important archaeological horizon of Yaz I-III, first individuated in the Murghab delta by the Soviet scholars right in the Yaz Tepe site
The Achaemenids in the History of Central Asia
No full textThe author in the volume devoted to the joint Italian/Russian/Turkmenian activities in south Turkmenistan entitled Archaeological Map of the Murghab delta, is dealing with an historical outline of the Achaemenid dynasty in Central Asia. Starting from the analyses of the epigraphic documentation, the author gives a view of the real geographic extension of the dynastic power in Central Asia, including Margiana, which never was listed as official province of the Empire
On large groups of symmetries of finite graphs embedded in spheres
No full textLet G be a finite group acting orthogonally on a pair
(S^d, \Gamma) where \Gamma is a finite, connected graph of genus g>1
embedded in a sphere S^d of dimension d. The 3-dimensional case d=3 has
recently been considered in a paper by C. Wang, S. Wang, Y. Zhang and the present
author where for each genus g>1 the maximum order of a G-action on a pair
(S^3, \Gamma) is determined and the corresponding graphs \Gamma are classified.
In the present paper we consider arbitrary dimensions d and prove that the order of
G is bounded above by a polynomial of degree d/2 in g if d is even and of
degree (d+1)/2 if d is odd; moreover the degree d/2 is best possible in even
dimensions d
- …
