101,428 research outputs found

    Contributors of the Summer Issue/Notes

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    Notes by William G. Greif, Louis Albert Hafner, William T. Huston, Maurice J. Moriarty, F. Richard Kramer, and George J. Murphy, Jr

    Letter, [Author unclear] to Paulina T. Merritt

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    Handwritten letter to Paulina Merritt from an unknown author, October 1, 1876.

    Handwritten biographical information on Paulina T. McClung Merritt

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    A handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.

    Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.

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    IFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Zehn lÿrische Selbst-Porträts ... /

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    Imprint date from Gesamtverzeichnis des deutschsprachigen Schrifttums (GV), 1700-1910.Introduction signed by the editor and publisher: Theodor Weicher.Includes poetry by each author.(from t.p.) Ferdinand von Saar -- Felix Dahn -- J. Trojan --Martin Greif -- Ernst von Wildenbruch -- Detlev von Liliencron -- Gustav Falke -- Arno Holz -- R. Dehmel -- Otto Julius Bierbaum.GV 1700-1910,Mode of access: Internet

    Las sociedades occidentales ante la emergencia de la peste

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    Se presenta un balance de las respuestas que se dieron a las pestes en el mundo occidental desdelas postrimerías de la Edad media hasta el presente, mostrando tanto las reacciones de la población como de la teoría médica y del poder público. En este sentido, analizar la historia de las respuestas desplegadas por las poblaciones del mundo occidental frente a la peste contribuye a entender algunos de los dilemas frente a los que nos encontramos hoy. Dilemas, por otra parte, que desde mediados de la última década del siglo pasado responden a una preocupación creciente ante la emergencia de nuevas enfermedades y la reemergencia de otras que se creían superadas.Fil: Greif, Esteban Augusto. Universidad de Buenos Aires. Facultad de Filosofía y Letras; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Multidisciplinario de Historia y Ciencias Humanas; Argentin
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