1,721,336 research outputs found
Active damping of a Bernoulli-Euler beam via end point impedance control using distributed parameter techniques
Get PDFThesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1987.MICROFICHE COPY AVAILABLE IN ARCHIVES AND SCIENCEBibliography: leaves 85-87.by Gregory Michael Procopio.M.S
Implementation of a general purpose dataflow multiprocessor
Get PDFThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1988.GRSN 409671Includes bibliographical references (leaves 151-155).by Gregory Michael Papadopoulos.Ph.D
Integrative modelling of protein abundance via sequence information
No full textUnderstanding the complex interactions between the transcriptome and proteome is essential in uncovering cellular mechanisms both in health and disease contexts. The underwhelming correlation between corresponding transcript and protein abundance suggests that regulatory processes tightly govern information flow surrounding transcription, translation and post translation; particularly in higher order organisms. Inherent difficulties associated with global proteome measurement make modelling protein abundance via proxies desirable, given the pivotal role that intra-cellular proteins play in cell regulation and function. In this thesis, a protein abundance predictor is developed across the human cell cycle using mRNA and translation abundance, determining that mRNA level alone insufficiently explains the transcriptome-proteome relationship. To expand the feature space, some 30 sequence-derived features (SDFs) were engineered that impact proteins before translation, and we demonstrated in our published works that overestimated outliers to fitted models (r 2 = 0.67) are associated with posttranslational regulation and degradation. It made sense then to expand on the concept of using sequence-engineered features as generalized predictors to expression; a large dataset was curated covering the entire human transcriptome to derive over 180 new features, spanning from genome to estimated post-translational modifications. SDFs were designed with scale and generality in mind; allowing for their application in a variety of ’omic studies. This newly generated resource was validated by systematically analysing intra-feature correlations and unsupervised learning techniques to mitigate inevitable multicollinearity. Finally, global protein abundance prediction using SDFs was attempted, finding that sequence information alone leads to model scores of r 2 = 0.45, with mRNA abundance included adding 5% to explaining model variance. Unpacking fitted SDF models using gene ontology analysis revealed a close relationship between SDFs and translation; helping to explain their improved model performance over mRNA level. This data driven approach helps to isolate proteins of interest by outlier detection, with SDF use biased towards predicting steady-state protein abundance
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The changing state pension age: Health impacts and ability to remain in employment
No full textThe main research questions examined in this thesis concern the interaction between an increasing State Pension Age (SPA) and health in the UK. The conclusions drawn from this investigation cast further light on the equality of an increasing SPA, including whether individuals in different circumstances will be able to continue working until reaching retirement age. In particular, this research suggests that inequality and the social gradient of health should be taken into account when designing a policy as influential as the State Pension.To explore the relationship between continued employment and health, a Dynamic Microsimulation Model is constructed. This projects individual health trajectories using English Longitudinal Study of Ageing data onto a representative Census base population. Within this framework, current and counterfactual SPA policy scenarios are used to assess the relative impact. This thesis furthers our understanding of the impact that the currently legislated SPA policy may have over the next 30 years.The study found a decline in overall health within the population of the UK throughout life. Each year the SPA was delayed resulted in an increasing proportion of individuals projected to fall into poor health before reaching the SPA. The results indicate that those in lower NS-SEC groups experiencing poor health at significantly earlier ages. This was found to be likely to lead to a much larger proportion of those in low NS-SEC groups experiencing difficulty remaining in employment before reaching SPA than their high NS-SEC group counterparts. The level of feedback between employment status and health was additionally found to be influential when defining the impact of a SPA change. It was found that if employment leads to an improvement in health, additional working years might protect individuals from an overall decline in health. If however continued employment is detrimental to health, declines in health may be exacerbated, leading to a rapid reduction in health state when nearing SPA.It was identified that allowing individuals to retire following 45 years of contributions has the potential to significantly decrease the number of individuals falling into poorer health while being under SPA. Conversely, the 50 years of contributions suggested by the Cridland (2016) Independent Review of the State Pension Age was found to pose little benefit in this regard. The health measure utilised was found to be influential when assessing the impact of policy. The study utilised the subjective Self-Reported Health measure, as well as an objective Hand-Grip Strength measure. Significantly different results were obtained, dependent on both the measure of health used and the manner in which conceptualisations of health were made
Continuities of Authoritarian Political Consolidation in Pre- and Post-Revolutionary Mexico
No full text(Statement of Responsibility) by Gregory Michael Hogan(Thesis) Thesis (B.A.) -- New College of Florida, 1987(Electronic Access) RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE(Bibliography) Includes bibliographical references.(Source of Description) This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.(Local) Faculty Sponsor: Bates, Margare
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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