48 research outputs found
Anticoagulation therapy and clinical outcomes in patients with recently diagnosed atrial fibrillation: Insights from the ARISTOTLE trial
No full textAbstract not availablePatrícia O. Guimarães, Daniel M.Wojdyla, John H. Alexander, Laine Thomas, Marco Alings, Greg C. Flaker, Sana M. Al-Khatiba, Michael Hanna, John D. Horowitz, Lars Wallenting, Christopher B. Granger, Renato D. Lope
Is quality of anticoagulation a 'wild card' in the treatment of patients with atrial fibrillation?
No full textUse of a Standardized Heparin Nomogram to Achieve Therapeutic Anticoagulation After Thrombolytic Therapy in Myocardial Infarction
No full text
Indirect contact heat recovery with solidification in thermochemical hydrogen production
No full textAn analysis is presented for the heat transfer from molten salt in the copper–chlorine thermochemical cycle for hydrogen production. For this cycle to become economical relative to other existing or developing technologies, effective heat recovery is very important. Heat recovery processes are investigated from molten CuCl (a product of the copper oxychloride decomposition process in the Cu–Cl cycle). Recovering heat from molten CuCl at 500 °C is challenging due to its phase change from liquid to solid. Based on a previous examination of different options for this heat recovery (including atomization with steam generation, casting/extrusion, drum flaker and a rotary spinning atomizer), the casting/extrusion method was deemed advantageous. Hence that process is considered here, with a counter-current air flow as a coolant. Predicted results for axial growth of the solid layer and variations of the coolant and wall temperatures are presented and discussed. The effects of the inner tube diameter and air mass flow rate are also investigated
Stroke prevention in the elderly atrial fibrillation patient with comorbid conditions: focus on non-vitamin K antagonist oral anticoagulants
No full textMohit K Turagam, Poonam Velagapudi, Greg C FlakerDivision of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO, USAAbstract: Stroke prevention in elderly atrial fibrillation patients remains a challenge. There is a high risk of stroke and systemic thromboembolism but also a high risk of bleeding if anticoagulants are prescribed. The elderly have increased chronic kidney disease, coronary artery disease, polypharmacy, and overall frailty. For all these reasons, anticoagulant use is underutilized in the elderly. In this manuscript, the benefits of non-vitamin K antagonist oral anticoagulants compared with warfarin in the elderly patient population with multiple comorbid conditions are reviewed.Keywords: non-vitamin K antagonist oral anticoagulants, novel oral anticoagulants, warfarin, dabigatran, rivaroxaban, apixaban, edoxaba
Indirect contact heat recovery with solidification in thermochemical hydrogen production
No full textAn analysis is presented for the heat transfer from molten salt in the copper–chlorine thermochemical cycle for hydrogen production. For this cycle to become economical relative to other existing or developing technologies, effective heat recovery is very important. Heat recovery processes are investigated from molten CuCl (a product of the copper oxychloride decomposition process in the Cu–Cl cycle). Recovering heat from molten CuCl at 500 °C is challenging due to its phase change from liquid to solid. Based on a previous examination of different options for this heat recovery (including atomization with steam generation, casting/extrusion, drum flaker and a rotary spinning atomizer), the casting/extrusion method was deemed advantageous. Hence that process is considered here, with a counter-current air flow as a coolant. Predicted results for axial growth of the solid layer and variations of the coolant and wall temperatures are presented and discussed. The effects of the inner tube diameter and air mass flow rate are also investigated
Ticagrelor as an Alternative for Clopidogrel-Associated Acute Arthritis
No full textA 65-year-old Caucasian man was hospitalized for a non-ST-elevation myocardial infarction. On discharge, the patient was started on multiple new medications, including clopidogrel and atorvastatin. Twenty-six days after discharge, he presented to the Emergency Department (ED) with polyarthralgias. He was instructed to stop atorvastatin and to follow up with rheumatology and cardiology clinic. At cardiology clinic follow-up 43 days after ED discharge, clopidogrel was discontinued and patient was switched to ticagrelor. On follow-up one month later, his symptoms had completely resolved. During the next 4 months, patient had routine follow-up due to participation in Cardiopulmonary Rehab and he had no cardiac events or recurrence of joint symptoms. Our patient had no history of arthritis. Because he initially presented with 2 medication classes associated with arthritis, each was withdrawn separately. The temporal association of patient’s symptomatic improvement strongly suggests that the arthritis was caused by clopidogrel. Our patient was able to tolerate ticagrelor with complete resolution of his arthritis and no cardiac events. Clopidogrel-induced arthritis is a rare adverse drug event. For patients with a recent drug-eluting stent, alternative antiplatelet therapy with ticagrelor may provide positive cardiac outcomes without similar adverse effects.</jats:p
