39,081 research outputs found
Supporting the Design of Phishing Education, Training and Awareness interventions: an LLM-based approach
No full textPhishing remains one of the most effective cyber threats in our digital world, affecting millions of organizations. Phishing education, training, and awareness programs are used to address employees’ lack of knowledge about phishing attacks. However, despite being very expensive, these interventions are not always effective, mainly due to the lack of customization of training materials based on the employees’ needs and profiles. In fact, creating customized training content for each employee and each context would require a huge effort from security practitioners and educators thus increasing costs even more. The proposal we present in this paper is to use Large Language Models to automate some steps in the design process of training content, which is tailored to the specific user profile
Blanda, Laos, Cerillae : guida archeologica dell'alto Tirreno cosentino / Emanuele Greco, Gioacchino Francesco La Torre
No full textFavorable Survival of In-Hospital Compared with Out-of-Hospital Refractory Cardiac Arrest Patients Treated with Extracorporeal Membrane Oxygenation: An Italian Tertiary Care Center Experience
No full textObjective: Extracorporeal membrane oxygenation (ECMO) support has been suggested to improve survival in patients with refractory in- and out-of-hospital cardiac arrest (IHCA, OHCA). Aim of the present study was to report our experience on the use of ECMO in adult patients with refractory IHCA and OHCA. We have further examined outcome differences between IHCA and OHCA and factors accounting for such differences.
Methods: Forty-two patients (31 males) with refractory cardiac arrest, 24 IHCA and 18 OHCA, were enrolled in this single centre, retrospective, observational study, from January 2006 to December 2010.
Results: There was significant difference in the time of no-flow (duration of untreated cardiac arrest) between the OHCA and IHCA patients (p<0.001). The time of low flow (duration of CPR prior to ECMO) was also significantly longer in the OHCA group compared with the IHCA one (77 mins vs 55 mins, p<0.001). ECMO implantation was successful in 38 (90%) of the 42 patients. ECMO support was positioned: 3 times (8%) in the operating room, 6 (16%) in the cardiac surgery intensive care unit, 21 (55%) in the emergency department, 5 (13%) in the catheterization laboratory and 3 (8%) in general ward. A total of 14 IHCA (58%) and 3 OHCA (16%) patients were weaned from ECMO (p<0.05). 11 IHCA (46%) and 1 OHCA (5% p<0.05) were discharged from intensive care unit (ICU). Among IHCA patients, 10 were alive at 6 months, 9 of whom (38%) with good neurological outcome. Among OHCA patients weaned from ECMO, one was alive at six months with good neurological outcome (5%, p<0.05 vs IHCA).
Conclusions: ECMO support should be considered as a resuscitation alternative in selected patients. More specifically, patients with witnessed IHCA have more benefits from ECMO treatment compared to those who experience an out-of-hospital cardiac arrest.
Formula
Author Disclosures: L. Avalli: None. G. Greco: None. F. Sangalli: None. L. Galbiati: None. M. Trabucchi: None. F. Formica: None. C. Costa: None. G. Ristagno: None. R. Fumagalli: None
Training of Special Education teachers in Greece, France, and Italy. Critical comments regarding Inclusive Education (ISTRUZIONE E FORMAZIONE DEGLI INSEGNANTI IN EDUCAZIONE SPECIALE IN GRECIA, ITALIA E F...
No full textSi tratta di un volume che si occupa della formazione degli insegnanti attraverso la disamina degli approcci teorici e di ricerca sull'educazione e sulla pedagogia speciali.
Nel contributo indicato, gli autori - E. Kourkoutas, greco; R. Caldin, italiana; M.-G. Prunier, francese - svolgono una dettagliata comparazione delle teorie e delle pratiche in pedagogia e in educazione speciali tra la Grecia, l'Italia e la Francia, mettendo in luce - dei vari Paesi - le "buone pratiche", le dimensioni teoriche, le prospettive inclusive
Favorable Survival of In-Hospital Compared with Out-of-Hospital Refractory Cardiac Arrest Patients Treated with Extracorporeal Membrane Oxygenation: An Italian Tertiary Care Center Experience
No full textObjective: Extracorporeal membrane oxygenation (ECMO) support has been suggested to improve survival in patients with refractory in- and out-of-hospital cardiac arrest (IHCA, OHCA). Aim of the present study was to report our experience on the use of ECMO in adult patients with refractory IHCA and OHCA. We have further examined outcome differences between IHCA and OHCA and factors accounting for such differences.
Methods: Forty-two patients (31 males) with refractory cardiac arrest, 24 IHCA and 18 OHCA, were enrolled in this single centre, retrospective, observational study, from January 2006 to December 2010.
Results: There was significant difference in the time of no-flow (duration of untreated cardiac arrest) between the OHCA and IHCA patients (p<0.001). The time of low flow (duration of CPR prior to ECMO) was also significantly longer in the OHCA group compared with the IHCA one (77 mins vs 55 mins, p<0.001). ECMO implantation was successful in 38 (90%) of the 42 patients. ECMO support was positioned: 3 times (8%) in the operating room, 6 (16%) in the cardiac surgery intensive care unit, 21 (55%) in the emergency department, 5 (13%) in the catheterization laboratory and 3 (8%) in general ward. A total of 14 IHCA (58%) and 3 OHCA (16%) patients were weaned from ECMO (p<0.05). 11 IHCA (46%) and 1 OHCA (5% p<0.05) were discharged from intensive care unit (ICU). Among IHCA patients, 10 were alive at 6 months, 9 of whom (38%) with good neurological outcome. Among OHCA patients weaned from ECMO, one was alive at six months with good neurological outcome (5%, p<0.05 vs IHCA).
Conclusions: ECMO support should be considered as a resuscitation alternative in selected patients. More specifically, patients with witnessed IHCA have more benefits from ECMO treatment compared to those who experience an out-of-hospital cardiac arrest.
Formula
Author Disclosures: L. Avalli: None. G. Greco: None. F. Sangalli: None. L. Galbiati: None. M. Trabucchi: None. F. Formica: None. C. Costa: None. G. Ristagno: None. R. Fumagalli: None
Expression of membrane-bound human leucocyte antigen-G in systemic sclerosis and systemic lupus erythematosus
No full textHuman leucocyte antigen-G (HLA-G) is a nonclassical class I major histocompatibility complex (MHC) molecule characterized by complex immunoregulatory and tolerogenic functions. Membrane-bound HLA-G is expressed on the surface of different cell populations in both physiological and pathological conditions. Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by widespread tissue fibrosis, vascular lesions and immunological alterations. Systemic lupus erythematosus is the prototypic systemic autoimmune disease affecting virtually any organ system, such as skin, joints, central nervous system, or kidneys. In SSc and SLE patients, the membrane expression of HLA-G on monocytes (0.88 ± 1.54 and 0.43 ± 0.75, respectively), CD4+ (0.42 ± 0.78 and 0.63 ± 0.48, respectively), CD8+ (2.65 ± 3.47 and 1.29 ± 1.34, respectively) and CD4+ CD8+ double-positive cells (13.87 ± 15.97 and 3.79 ± 3.11, respectively) was significantly higher than in healthy controls (0.12 ± 0.07; 0.01 ± 0.01; 0.14 ± 0.20 and 0.32 ± 0.38, respectively) (p < 0.0001). Our results show that in SSc and SLE the membrane expression of HLA-G by different subpopulations of peripheral blood mononuclear cells (PBMC) is increased, suggesting a potential role of HLA-G molecules in the complex immunological pathogenesis of these two autoimmune disorders
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