1,721,004 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Reply to Christ et al.: LQT1 and JLNS phenotypes in hiPSC-derived cardiomyocytes are due to KCNQ1 mutations
No full textMechanistic studies of substrate activation by the human CDK-activating kinase and its inhibition by small-molecule ligands
No full textThe human cyclin-dependent kinase (CDK)-activating kinase (CAK), a heterotrimeric protein complex consisting of CDK7, cyclin H, and MAT1, is a dual regulator of both transcription and the cell cycle. As a subcomplex of the general transcription factor TFIIH, it regulates transcription initiation and co-transcriptional pre-mRNA processing through phosphorylation of the C-terminal domain of RNA polymerase II. As a free complex, it regulates the cell cycle by catalysing the activating phosphorylation of CDK proteins. Due to its key activities in such fundamental cellular processes, which are commonly dysregulated in tumorigenesis, several small-molecule inhibitors of CDK7 have been developed as anti-cancer drugs.Despite a wealth of existing structural and biochemical data concerning the architecture, functions, and inhibition of the human CAK, several key questions remain. For instance, we currently lack an understanding of the molecular mechanisms by which the CAK recognises its CDK substrates. Additionally, targeting of CDK7 for cancer treatment is challenged by issues of non-selective binding of inhibitors to related CDKs, as well as possible treatment resistance.The work presented in this thesis aims to address several of these outstanding questions and challenges. I present structural and mechanistic studies of CAK-substrate complexes, which reveal the basis of CDK substrate recognition by the CAK. I additionally present structures of the CAK bound to a series of small-molecule inhibitors, thereby providing insights into inhibitor selectivity relevant to the design of future drugs, while establishing workflows for high-throughput, high-resolution structure determination by cryo-EM applicable to structure-based drug design efforts of other challenging targets. Finally, I present structural and biochemical analysis of a mutant form of the CAK that is resistant to certain inhibitors. Together, this work advances our understanding of the functions of this “master regulator” and how it can be more effectively targeted in disease
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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