106,644 research outputs found
Joshua Davis: Author of Spare Parts
No full textCitation: K-State First (2016). Joshua Davis: Author of Spare Parts [Flier]. Manhattan, Kansas: K-State First.Flyer advertising Joshua Davis's author talk at Kansas State University
Developing a new curriculum for school age learners.
No full textThe global reach of English has spurred a rethinking of its role in education and consequently, a rethinking of how to teach it. The accounts in this volume represent differences in educational systems, language teaching traditions, purposes for learning English, and responses to educational reform. In many countries the role of English is shifting from language as a subject and language as a means for academic learning and for cultural communication and exchange
Steven Johnson Author Talk Poster
No full textK-State Book NetworkA poster advertising an author talk by Steven Johnson at Kansas State University on September 3, 2014. Steven Johnson's book "The Ghost Map" was the 2014-2015 common book
Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease
No full textTo date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic determinants shared among these involved tissues. To characterize these T cells at the molecular level, we compared the T cell antigen receptor (TcR) variable (V) region gene usage in thyroid, retroorbital, pretibial tissue, and peripheral blood mononuclear cells of two patients with Graves' disease, ophthalmopathy, and pretibial dermopathy. Ribonucleic acid was extracted, reverse transcribed, and amplified using the PCR and 22 V alpha and 23 V beta gene-specific oligonucleotide primers. The resulting TcR V alpha and V beta transcripts were verified by Southern hybridization analysis using TcR C region-specific, digoxigenin-labeled oligonucleotide probes. In addition, complementarity determining regions 3 and junctional regions of TcR V beta genes were sequenced. Marked similarities of intrathyroidal, retroorbital, and pretibial TcR V alpha and V beta gene repertoires were noted with respect to the degree of TcR V gene restriction and the patterns of individual V genes expressed. Sequence analysis of junctional domains of V beta families revealed oligoclonality of intrahyroidal, retroorbital, and pretibial T cells. In addition, certain conserved junctional motifs were shared by T cells derived the thyroid gland and the extrathyroidal sites. Our results suggest that in the two patients with Graves' disease and extrathyroidal manifestations studied, similar antigenic determinants may have contributed to the recruitment and oligoclonal expansion of T cells both within the thyroid gland and at the involved extrathyroidal sites
A Genomic Point Mutation in the Extracellular Domain of the Thyrotropin Receptor in Patients with Graves’ Ophthalmopathy
No full textOrbital and pretibial fibroblasts are targets of autoimmune attack in Graves' ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves' disease and the reason for the association of GO and PTD with hyperthyroidism are unknown. RNA encoding the full-length extracellular domain of the TSH receptor has been demonstrated in orbital and dermal fibroblasts from patients with GO and normal subjects, suggesting a possible antigenic link between fibroblasts and thyrocytes. RNA was isolated from cultured orbital, pretibial, and abdominal fibroblasts obtained from patients with severe GO (n = 22) and normal subjects (n = 5). RNA was reverse transcribed, and the resulting cDNA was amplified by the polymerase chain reaction, using primers spanning overlapping regions of the entire extracellular domain of the TSH receptor. Nucleotide sequence analysis showed an A for C substitution in the first position of codon 52 in 2 of the patients, both of whom had GO, PTD, and acropachy. Genomic DNA isolated from the 2 affected patients, and not from an additional 12 normal subjects, revealed the codon 52 mutation by direct sequencing and AciI restriction enzyme digestions. In conclusion, we have demonstrated the presence of a genomic point mutation, leading to a threonine for proline amino acid shift in the predicted peptide, in the extracellular domain of the TSH receptor in two patients with severe GO, PTD, acropachy, and high thyroid-stimulating immunoglobulin levels. RNA encoding this mutant product was demonstrated in the fibroblasts of these patients. We suggest that the TSH receptor may be an important fibroblast autoantigen in GO and PTD, and that this mutant form of the receptor may have unique immunogenic properties
[Note from J. P. Adamcik to L. C. Graves, December 2, 1963 #1]
No full textNote from J. P. Adamcik and K. L. Anderton to L. C. Graves regarding Lee Harvey Oswald practicing at the Sportsdrome Gun Range
Challenges and Opportunities in Designing a New Curriculum for School-Age Learners pp. 1-12
No full textThe global reach of English has spurred a rethinking of its role in education and, consequently, a rethinking of how to teach it. This introductory contribution is aimed at presenting new perspectives in English curriculum development
[Note from J. P. Adamcik to L. C. Graves, December 2, 1963 #2]
No full textNote from J. P. Adamcick and K. L. Anderton to L. C. Graves regarding Lee Harvey Oswald practicing at the Sportsdrome Gun Range
To Live Amongst the Dead: an Ethnographic Exploration of Mass Graves in Cambodia
No full textThis thesis uses mass graves as a lens through which to examine how people in contemporary Cambodia use the Khmer Rouge period (1975 – 1979) to reconstitute and re-imagine the world they live in. Based on sixteen months of multisited ethnographic fieldwork, this thesis will argue that the Khmer Rouge regime was a critical event (Das 1997) in Cambodian life, and as such has triggered a re-shaping of relationships between local and the national, and the national and the global, leading to new forms of social and community life and action in post Khmer Rouge Cambodia. As physical markers of violence and political instability, mass graves are inherently political and articulate these re-imaginations on the state, community, and individual level. The Cambodian state exercises and legitimates its authority by constructing modern history in reference to a narrative of liberation from the Khmer Rouge, and the ‘innocent suffering’ of Cambodia and its people, while local communities use Buddhism and animism to narrate and conceptualise the period, bringing it into expected and understandable events within Khmer Buddhist cosmology. These approaches are not necessarily in opposition to one another, but rather represent the overlapping plurality of connections with mass graves.
This thesis provides a unique exploration of social relationships to mass graves in Cambodia contributing to debates within the anthropology of politics, violence and collective memory by examining how moments of national mass violence re-shape the state and relationships within it, and how destructive periods of violence nonetheless create new fields for the imagination of the political, the religious, and the social. It also contributes to the emerging field of Cambodian ethnography that combines local considerations with wider national and geo-political discourses and how these are played out at the local level
(SNP068) Louis Graves interviewed by Reed Engle, transcribed by Joy K. Stiles
No full textRecords an interview with Louis Graves, who grew up in Madison County, Virginia, not far from the site where President Herbert Hoover would construct a rustic retreat known as Rapidan Camp, and later as Camp Hoover. Hoover paid for the project out of his own funds and the camp was constructed by a detachment of U.S. Marines as a military exercise by March, 1929. Louis Graves recalls speeches given by President Hoover and other dignitaries in Madison, Va., as part of a day-long Hoover Day celebration on August 9, 1929. Graves relates that more than 10,000 people attended the event, including Virginia governor Harry F. Byrd, who arrived at the celebration aboard an Army reconnaissance blimp. Includes a discussion of the economic situation in Madison County in 1929, during a time of prolonged drought and at the onset of the Great Depression.
There is no audio recording for this interview; interview consists of transcript only.https://commons.lib.jmu.edu/snp/1123/thumbnail.jp
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