1,721,401 research outputs found
Electrical impedance tomography: just another tool or a real advance towards precision-medicine in mechanical ventilation?
No full textNo abstract availabl
Viral nanoparticles as macromolecular devices for new therapeutic and pharmaceutical approaches
No full textViral nanoparticles are molecular cages derived from the assembly of viral structural proteins. They bear several peculiar features as proper dimensions for nanoscale applications, size homogeneity, an intrinsic robustness, a large surface area to mass ratio and a defined, repetitive and symmetric macromolecular organization. A number of expression strategies, using various biological systems, efficiently enable the production of significant quantities of viral nanoparticles, which can be easily purified. Genetic engineering and in vitro chemical modification consent to manipulate of the outer and inner surface of these nanocages, allowing specific changes of the original physico-chemical and biological properties. Moreover, several studies have focused on the in vitro disassembly/reassembly and gating of viral nanoparticles, with the aim of encapsulating exogenous molecules inside and therefore improving their potential as containment delivery devices. These technological progresses have led research to a growing variety of applications in different fields such as biomedicine, pharmacology, separation science, catalytic chemistry, crop pest control and material science. In this review we will focus on the strategies used to modify the characteristics of viral nanoparticles and on their use in biomedicine and pharmacology
Electric field in SPS: geometry and pulsed current effects
No full textCited By (since 1996):1 Export Date: 19 August 2014 CODEN: NSKRE Correspondence Address: Grasso, S.; School of Engineering and Materials Science, Nanoforce Technology Limited, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom; email: [email protected] References: Omori, M., (2000) Materials Science and Engineering A-Structural Materials Properties Microstructure and Processing, 287, pp. 183-188; Munir, Z., Anselmi-Tamburini, U., Ohyanagi, M., (2006) J. Mater. Sci., 41, pp. 763-777; Cologna, M., Prette, A.L.G., Raj, R., (2011) J. Am. Ceram. Soc., 94, pp. 316-319; Ghosh, S., Chokshi, A.H., Lee, P., Raj, R., (2009) J. Am. Ceram. Soc., 92, pp. 1856-1859; Conrad, H., Yang, D., (2013) Mater. Sci. Eng., A, 559, pp. 591-594; Zhang, J., Zavaliangos, A., Groza, J., The effect of specimen conductivity on current and temperature distribution in field activated sintering (2003) International Conference on Powder Metallurgy and Particulate Materials, , Las Vegas; Zavaliangos, A., Zhang, J., Krammer, M., Groza, J., (2004) Materials Science and Engineering A-Structural Materials Properties Microstructure and Processing, 379, pp. 218-228; Olevsky, E.A., Garcia-Cardona, C., Bradbury, W.L., Haines, C.D., Martin, D.G., Kapoor, D., (2012) J. Am. Ceram. Soc., 95, pp. 2414-2422; Grasso, S., Sakka, Y., Maizza, G., (2009) Mater. Trans., 50, pp. 2111-2114; Anselmi-Tamburini, U., Gennari, S., Garay, J., Munir, Z., (2005) Materials Science and Engineering A-Structural Materials Properties Microstructure and Processing, 394, pp. 139-148; Vanmeensel, K., Laptev, A., Hennicke, J., Vleugels, J., Van Der Biest, O., (2005) Acta Mater., 53, pp. 4379-4388; Maizza, G., Grasso, S., Sakka, Y., (2009) J. Mater. Sci., 44, pp. 1219-1236; Grasso, S., Sakka, Y., Maizza, G., (2009) Sci. Technol. Adv. Mater., 10, p. 053001 Electrical heating of the graphite die and punch assembly is a unique feature of the spark plasma sintering (SPS) process. The high currents needed to heat the die, despite its low resistance, can produce an electric field across the ceramic specimens that may be enough to induce field assisted sintering. Despite the large number of publications of SPS, the electric field intensity has not been accounted in previous investigations. A FEM model is employed to quantify the magnitude of electric field applied during sintering across zirconia sample. We show that the electric field depends most critically on the ratio of the outer and inner diameter of the die. We also report that the intensity of the electric field across the sintering sample is significantly affected by duty cycle of the pulsed current. © 2013 The Ceramic Society of Japan. All rights reserved.Cited By (since 1996):1 Export Date: 19 August 2014 CODEN: NSKRE Correspondence Address: Grasso, S.; School of Engineering and Materials Science, Nanoforce Technology Limited, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom; email: [email protected] References: Omori, M., (2000) Materials Science and Engineering A-Structural Materials Properties Microstructure and Processing, 287, pp. 183-188; Munir, Z., Anselmi-Tamburini, U., Ohyanagi, M., (2006) J. Mater. Sci., 41, pp. 763-777; Cologna, M., Prette, A.L.G., Raj, R., (2011) J. Am. Ceram. Soc., 94, pp. 316-319; Ghosh, S., Chokshi, A.H., Lee, P., Raj, R., (2009) J. Am. Ceram. Soc., 92, pp. 1856-1859; Conrad, H., Yang, D., (2013) Mater. Sci. Eng., A, 559, pp. 591-594; Zhang, J., Zavaliangos, A., Groza, J., The effect of specimen conductivity on current and temperature distribution in field activated sintering (2003) International Conference on Powder Metallurgy and Particulate Materials, , Las Vegas; Zavaliangos, A., Zhang, J., Krammer, M., Groza, J., (2004) Materials Science and Engineering A-Structural Materials Properties Microstructure and Processing, 379, pp. 218-228; Olevsky, E.A., Garcia-Cardona, C., Bradbury, W.L., Haines, C.D., Martin, D.G., Kapoor, D., (2012) J. Am. Ceram. Soc., 95, pp. 2414-2422; Grasso, S., Sakka, Y., Maizza, G., (2009) Mater. Trans., 50, pp. 2111-2114; Anselmi-Tamburini, U., Gennari, S., Garay, J., Munir, Z., (2005) Materials Science and Engineering A-Structural Materials Properties Microstructure and Processing, 394, pp. 139-148; Vanmeensel, K., Laptev, A., Hennicke, J., Vleugels, J., Van Der Biest, O., (2005) Acta Mater., 53, pp. 4379-4388; Maizza, G., Grasso, S., Sakka, Y., (2009) J. Mater. Sci., 44, pp. 1219-1236; Grasso, S., Sakka, Y., Maizza, G., (2009) Sci. Technol. Adv. Mater., 10, p. 053001 Electrical heating of the graphite die and punch assembly is a unique feature of the spark plasma sintering (SPS) process. The high currents needed to heat the die, despite its low resistance, can produce an electric field across the ceramic specimens that may be enough to induce field assisted sintering. Despite the large number of publications of SPS, the electric field intensity has not been accounted in previous investigations. A FEM model is employed to quantify the magnitude of electric field applied during sintering across zirconia sample. We show that the electric field depends most critically on the ratio of the outer and inner diameter of the die. We also report that the intensity of the electric field across the sintering sample is significantly affected by duty cycle of the pulsed current. © 2013 The Ceramic Society of Japan. All rights reserved
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Pressure effects on temperature distribution during spark plasma sintering with graphite sample
No full textTranspulmonary pressure-based mechanical ventilation in acute respiratory distress syndrome from theory to practice?
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