1,721,194 research outputs found
Le colombaie nel vicentino
Full text linkQuesto contributo, facente parte di un più ampio progetto, ha lo scopo di riportare alla giusta attenzione una pratica largamente utilizzata in gran parte del mondo da molti secoli, ma ormai spesso abbandonata: l’allevamento dei colombi nelle colombaie, manufatti appositamente concepiti e costruiti allo scopo. Questa pratica era nel passato molto diffusa anche nel Vicentino e ne restano numerose tracce materiali, le colombaie, e immateriali, come i toponimi e la tradizione culinariaThis contribution, which is part of a larger project, aims to bring to the right attention a practice widely used in most of the world for many centuries, but now often abandoned: the breeding of pigeons in dovecotes, artifacts specially conceived and built at scope. In the past, this practice was also widespread in the Vicenza area and numerous material traces remain, such as the dovecotes, and immaterial ones, such as toponyms and culinary traditio
Multiple myeloma: pathogenesis of the osteolysis and critical aspects in the orthopaedic management
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Progettare città pubbliche per rinnovare i ruoli dell'azione pubblica. Ipotesi di lavoro a Trieste
No full textIl saggio propone una riflessione sul ruolo che l'azione pubblica oggi può giocare nel fare fronte a una rinvigorita questione della casa. Tratta in primo luogo di un vuoto, quello dell'edilizia residenziale pubblica, che nel nostro Paese è oggi un dato di fatto che di per sé fa problema proprio perché dimostra l'incapacità – da parte delle politiche pubbliche nazionali (e regionali) – di cogliere l'emergere di una vera e propria nuova emergenza abitativa. Un secondo aspetto attiene al cambiamento nella domanda sociale. Un cambiamento importante, anche se non ancora del tutto sufficientemente indagato. Rispetto a questo cambiamento può essere letto l'emergere di un nuovo approccio alla città pubblica, quello dell'edilizia sociale. Lo slittamento lessicale – da edilizia residenziale pubblica a edilizia sociale o addirittura al termine anglofono social housing – sottende tuttavia un modo completamente diverso dal passato di intendere le relazioni tra parole e cose. Il testo tratta infine della specificità del caso triestino, nell'intento di dimostrare un semplice assunto: di fronte a una questione casa che si va complessificando, la risposta non può più essere quella di un modello assoluto, universale, che tratti la questione in maniera aggregata e generale, quanto piuttosto la ricerca di modelli locali, parziali e al plurale, che con le risorse disponibili riescano almeno in parte a scomporre e ad affrontare un problema di così grande difficoltà
Etidronate inhibits osteoclast adhesion to bone surfaces but does not interfere with their specific recognition of single bone proteins
No full textBisphosphonates are nonbiodegradable pyrophosphate analogues that are increasingly used for inhibiting bone resorption in disorders characterized by excessive bone loss; they are in fact generally considered potent inhibitors of osteoclastic bone resorption both in vivo and in vitro but the mechanism by which these compounds exert their effect remains to be clarified. Data obtained on human systems in vitro are in particular lacking. The aim of this study was to assess the effect of etidronate (EHDP), one of the early compounds of bisphosphonates family, on osteoclast-matrix interactions and on bone resorption in a human in vitro system, using as an experimental model, osteoclast-like cells derived from giant cell tumors of bone (GCT). We reported that the presence of EHDP at the concentration ranging from 10-3 M to 10-7 M exerted a dose-dependent inhibition of the bone resorption activity with a maximal effect at 10-5 M. Because bisphosphonates owe the specificy of their actions to their ability of binding to bone surfaces, we performed adhesion assay using bone slices that had been pre-treated with solution of EHDP, at the established inhibitory concentration of hone resorption. Results showed that the morphology of cells plated onto bone slices pre-treated with the bisphosphonate was not significantly different from the control while the number of adherent cells was significantly reduced, by the treatment of about 50% vs control. Since osteoclast adhesion to the bone surface is mediated by the interaction with some adhesive proteins of extracellular bone matrix such as bone sialoprotein, osteopontin and fibronectin, furthermore the effect of EHDP on osteoclast adhesion onto specific extracellular matrix proteins, was also tested. In this case the presence of EHDP in the medium did not modify the percentage of cell adhesion compared to the control, indicating that the inhibitory effect of EHDP on cell adhesion onto hone slices, was probably not due to the interference with adhesion process of cells with specific hone matrix proteins. However we cannot exclude a possible effect on this process of EHDP that could be evident when all the components of the extracellular matrix ar present. In summary this work provides the first evidences of the inhibitory effect of EHDP on human osteoclast-like cells in vitro, confirming animal model data, possibly by a mechanism involving the adhesion process
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