1,720,957 research outputs found
Does the paediatric immunotherapy service for allergic rhinitis at Southampton Children's Hospital provide a safe and effective service to the right patients?
No full textTaking a longer LEAP? A service evaluation of early peanut screening and outcomes in higher risk infants
No full textFifteen-minute consultation: the EATERS method for the diagnosis of food allergies
No full textThe EATERS mnemonic is a novel method for taking an allergy focused clinical history. It provides a degree of certainty for diagnosing food allergy and can be used in both IgE and non IgE mediated reactions. EATERS will allow health care professionals to use their existing clinical skills to interpret the history of an allergic reaction, and by doing so will help to make sense of allergy test results.</p
Chlorhexidine allergy diagnosis in the UK: Clinical features and investigational pathways
No full textObjectives: Asthma is a chronic respiratory disease, characterised by relapse and remission of symptoms. The Arg16 variant of the ADRB2 gene has been associated with diminished clinical responsiveness to β2‐agonists, and increased risk of asthma exacerbations. The association between this variant and asthma‐related prescribing is unclear. Our hypothesis is that the Arg16 allele is associated with long‐term increased use of prescribed asthma medication.Method: A secondary analysis of BREATHE, a study of gene‐environment associations with asthma severity, was undertaken. BREATHE data were collected on participants with asthma, aged 3‐22 years, between 2003 and 2005, in Tayside and Fife, Scotland. Through collaboration with the Health Informatics Centre in Dundee, BREATHE was linked to several databases: Accident & Emergency, community prescribing and Scottish Morbidity Records (hospital admissions). This linkage allows exploration of associations between genetic variation and prescribing. Data between 2005 and 2013 were analysed using random effects generalised linear models.Results: The analysis was performed on 1009 individuals. Over the 9‐year period, a significant association was found between individuals homozygous for the Arg16 variant and the prescribing of prednisolone (Gly/Arg vs Arg/Arg—Incidence Rate Ratio (IRR): 1.54, 95% CI: 1.06‐2.25; Gly/Gly vs Arg/Arg—IRR: 1.64, 95% CI: 1.12‐2.42). A significant association was also found between the Arg16 variant and prescribing of anti‐leukotriene antagonists (Gly/Gly vs Arg/Arg—IRR: 2.33, 95% CI: 1.06‐5.13) and a combination of long‐acting β2‐agonist and corticosteroids (Gly/Arg vs Arg/Arg—IRR: 2.80, 95% CI: 1.35‐5.81; Gly/Gly vs Arg/Arg—IRR: 3.15, 95% CI: 1.50‐6.63). Over the 9‐year period, children and adults with the Arg/Arg genotype cost more £250 to the NHS than children and adults with the Gly/Gly or Gly/Arg genotype.Conclusions: Homozygous individuals with the Arg/Arg variant are associated with long‐term increased prescribing of asthma medication. Defining subgroups of individuals requiring more medication could help develop targeted management strategies
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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