124 research outputs found
Profile: Brian Kiley
No full textBrian Kiley, head monologue writer for Conan O\u27Brien, has published his second novel, Maybe Kevin (HumorOutcasts Press). He\u27s also the author of The Astounding Misadventures of Rory Collins
Cold & fire
No full text"Cold & Fire", a song by the Australian band Dear Anonymous, was produced as part of the Indie 100 research intensive project within the Independent Music Project (IMP). The IMP is an ongoing, interdisciplinary research arm within QUT. The song's author is Julia Kourtidis
Cobwebs (Just a Minute)
No full text"Cobwebs (Just a Minute), a song by the Australian artist Charlotte Emily, was produced as part of the Indie 100 research intensive project within the Independent Music Project (IMP). The IMP is an ongoing, interdisciplinary research arm within QUT. The song's author is Charlotte Boumford
The Problem of the West[ern]
No full textThree great Western films—Stagecoach, The Man Who Shot Liberty Valance, and the contemporary No Country for Old Men—delve deep into the American psyche and make a broad claim that the American way of mixing freedom and rule is inherently flawed.
Author information: Kiley Duhn is a Business Economics and Accountancy double major and Political Science minor at Miami University in Oxford, Ohio. After graduating in the Class of 2019, she plans to pursue a career in tax consulting at a public accounting firm
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Learning from new perspectives: Using sparse data and multiple views to predict cancer progression and treatment
No full textAdvancements in sequencing technology have led to an influx of cancer genomics data, transforming cancer research into a field limited by data interpretation rather than acquisition. Machine learning methods that can make use of this wealth of data are desperately needed. Similarly, patient stratification is a critical task in cancer diagnosis and treatment. While stratification approaches using various biomarkers for patient-to-patient comparisons have been successful in elucidating previously unseen subtypes, the potential of many other sparse but rich genotype and phenotype data (e.g. tumor images) remains untapped. To this end, I present two methods. The first uses social network analysis techniques to extract subtypes from sparse data. The second is a semi-supervised multiview learning framework that integrates both prior knowledge and a variety of genomic data to predict outcomes in cancer. Crucially, this method accommodates samples for which we have different data types, paving the way for integration of data from past studies.I apply these methods to several cancer datasets. Of note, I show that TCGA--defined molecular subtypes of glioblastoma are independent of both tumor location and volume, and that both the imaging and genomic data provide important perspectives of the disease. Analysis of a large drug sensitivity database identifies an epigenetic effect from chromatin modifiers that lends sensitivity to Panobinostat. Multiview learning, the second method I developed, also outperforms other methods in predicting sensitivity in all of the study drugs. In this dissertation I begin with unsupervised single--platform analysis, then combine multiple platforms, and finally analyze many data platforms using semi--supervised analysis
Dan Kiley en la casa Miller
No full textEl propósito de esta tesis es estudiar los aspectos fundamentales de la obra del paisajista norteamericano Dan Kiley a través del ejemplo de la casa Miller en Columbus, Indiana. A la hora de abordar el estudio se ha tratado por una parte de estudiar y explicar cuánto hay de relevante en esta obra, pero también de situarla en su contexto. Éste es, además, múltiple: el de la obra, de su autor, el del lugar en que se encuentra y el del momento cultural e histórico en que se produce. En el caso de la casa Miller, la autoría es compartida, y el resultado final, como ocurre en muchos casos de viviendas unifamiliares, responde a un carácter coral, en el que los protagonistas son varios, con mayor o menor influencia, pero indispensables todos ellos en la visión final de conjunto. El primero de los aspectos a considerar son los antecedentes que la han hecho posible ya que el entorno que conforma el universo de Dan Kiley hasta llegar a Columbus es fundamental para entender las circunstancias de partida de una obra como la casa Miller: sus años previos a la universidad, su particular relación con el paisaje a través de sus diferentes trabajos, su extenso conocimiento de las especies de plantas y la experiencia acumulada trabajando para Warren Manning, como la formación basada en la enseñanza, herencia de Olsmted y de las Bellas Artes. Después, sus compañeros de Harvard Eckbo y Rose, la influencia dentro de la universidad tanto de Walter Gropius como de los paisajistas Thomas Church o Christopher Tunnard y de los jardines realizados en Europa durante las primeras décadas del siglo XX conocidos a través de las publicaciones y de la arquitectura de Mies van der Rohe. Años más tarde, después de haber abandonado Harvard, la decisiva influencia de Eero Saarinen y también la de sus relaciones con los diversos colaboradores, los primeros viajes a Europa y con ello la posibilidad de visitar las grandes obras de Le Nôtre. Por otro lado, y en paralelo, la biografía de Irwin Miller, propietario de la casa, nos lleva hasta el momento en el que se ponen en contacto las tres figuras clave para el inicio de las obras (Miller, Saarinen y Kiley) terminando de situar a la casa Miller en el contexto biográfico de su creación. El análisis del lugar, una ciudad tan especial como Columbus, nos remite continuamente a la figura de Irwin Miller, manteniendo siempre una relación indisoluble entre este singular patrono y su ciudad, materializada en la creación del Architecture Program. La primera parte del trabajo aborda estos temas, alternando entre una figura y otra, aunque todas las partes se encuentran ligadas entre sí. En la segunda parte de la tesis se analiza en profundidad primero la casa Miller y después con una mayor precisión los jardines: su esquema compositivo general, sus tres partes diferenciadas y dentro de ellas las sucesivas subpartes que las componen. El análisis se estructura en tres fases: una primera descriptiva del desarrollo del proyecto hasta su materialización en la obra, la siguiente que analiza lo realmente ejecutado y por último los cambios sufridos a lo largo del tiempo. En cuanto al análisis propio de la casa y los jardines, la información de los planos, así como de las fotografías familiares, junto con las imágenes más oficiales de la casa pertenecientes a Ezra Stoller y Balthazar Korab, permitirá conocer los cambios producidos a lo largo del tiempo debidos a diversos factores, como el cambio de criterio en cuanto al uso o decisiones personales del matrimonio Miller: sustitución de plantas y árboles, desaparición de elementos curiosos como las cascadas del techo de uno de los porches, o aparición de elementos singulares que formaran parte de las visiones ya clásicas de la casa, como la escultura de Henry Moore. La tercera parte de la tesis describe la influencia de los jardines de Le Nôtre en el jardín de la casa Miller, gracias a la utilización y adaptación de numerosos recursos del jardín barroco francés, y se configura, junto con el análisis de las obras de jardín doméstico más significativas de Kiley en su obra posterior a la Miller, como el análisis final de todo el trabajo. La utilización de estos instrumentos depurados bajo una estética formal propia del movimiento moderno tiene una singularidad única en los jardines de la Miller, y a pesar de que a lo largo de su carrera Dan Kiley convirtió esta utilización en una constante, no logró la armonía demostrada en esta residencia de Columbus en ninguno de los jardines posteriores en cuanto a forma, escala, relación entre las partes, respuesta a las necesidades de uso y de evolución a lo largo del tiempo. ABSTRACT The purpose of this thesis is to study the fundamental aspects of the work of the american landscape architect Dan Kiley through the example of the Miller House in Columbus, Indiana. When addressing the study it was treated on the one hand to study and explain how much is relevant in this work, but also put it into context. This is also multiple: the work, its author, the place where it lands and the cultural and historical context in which it occurs. In the case of the Miller house, the authorship is shared, and the end result, as in many cases houses, responds to a coral nature, in which the protagonists are several, with more or less influence on it, but indispensable all of them in the final overview. The first aspect to be considered are the antecedents that made it possible, because the environment which forms the universe of Dan Kiley to reach Columbus is essential to understand the circumstances of departure for a work like the Miller house: his previous years of college, his particular relationship with the landscape through his different jobs, his extensive knowledge of species of plants and the accumulated experience working for Warren Manning, and also the training based on Olmsted and Beaux Arts heritage . After that, his Harvard fellows Eckbo and Rose, the influence from Walter Gropius Thomas Church and Christopher Tunnard within the university, and also the landscape and garden made in Europe during the first decades of the twentieth century known through publications and the architecture of Mies van der Rohe. Years later, after leaving Harvard , the decisive influence of Eero Saarinen and also his relationships with various partners, the first trips to Europe and therefore the opportunity to visit the great works of Le Nôtre. On the other hand, and in parallel, Irwin Miller´s biography, owner of the house, takes us to the time when the three key figures come into contact to the start the construction (Miller, Saarinen and Kiley) putting the Miller house into the biographical context of its creation. The analysis of the place, a very special city like Columbus, continually refers us to Irwin Miller´s figure while maintaining an indissoluble relationship between employer and this unique city, materialized in the creation of the Architecture Program. The first part of the work deals with these issues, alternating between one figure and another, although all parties are linked. The second part of the thesis analyzes in depth Miller´s house and then with greater precision the gardens: its overall compositional scheme, its three distinct parts and within them the successive subparts that compose the garden The analysis is divided into three phases: the first one is focused in the project development to its materialization in the final work, the second one which analyzes what is really executed and finally the changes undergone over time. As for the own analysis of the house and gardens, the information drawings, as well as family photographs, along with the official pictures of the house belonging to Ezra Stoller and Balthazar Korab, will reveal the changes throughout time due to various factors, as the change in criterion for the use, or Miller´s marriage personal decisions: replacement of plants and trees, disappearance of curious elements like waterfalls roof of one of the porches, or appearance of single elements that now have become part of the classic visions of the house, like the sculpture of Henry Moore. The third part of the thesis describes the influence of the gardens of Le Nôtre in the garden of Miller´s house, through the use and adaptation of numerous resources from the French Baroque garden, and it is configured as the final analysis of of the work, also with the description of Kiley´s most significant post-Miller one family housing gardens. The use of these released under its own formal aesthetics of modernism instruments has a unique singularity in the gardens of the Miller´s , and although Dan Kiley turned this use in a constant throughout his career, he never got to the harmony demonstrated in Columbus residence in any of the later gardens in form, scale, relationship between the parties, responding to the needs of use and evolution over time
Apparent total tract macronutrient digestibility, fecal characteristics, urinalysis, fecal metabolites, serum chemistry, and voluntary physical activity levels of healthy adult dogs fed extruded, mildly cooked and raw foods
No full textThe pet food market continues to be strong, with much of the growth coming from super- premium foods and those with novel formats or processing methods. In addition to canned and extruded diets, lightly cooked and raw diets are available today. Despite the increase in their popularity, little research has been performed on such diets. The objective of this study was to determine the apparent total tract macronutrient digestibility (ATTD), fecal characteristics and metabolites, serum chemistry metabolic profile, urinalysis, and voluntary physical activity levels of adult dogs fed the following commercial dog diets: 1) Purina Dog Chow (DC), as the control diet; 2) Freshpet Vital Balanced Complete Nutrition (CN); 3) Freshpet Roasted Meals (RM); 4) Freshpet Vital Raw (VR). All procedures were approved by the University of Illinois Institutional Animal Care and Use Committee prior to the study. Eight dogs (mean age = 3.6 yr ± 0.29; mean body weight (BW) = 13.0 kg ± 0.84) were used in a replicated 4x4 Latin square design. Each period consisted of 28 d, with a 14-d adaptation phase followed by a 7-d phase for measuring voluntary physical activity, a 1-d adaptation phase to metabolic cages, a 5-d phase for fecal and urine collection, and 1-d for blood collection. Fresh fecal samples were collected for pH, moisture, and metabolite measurements. Food was fed twice daily and at a rate to maintain BW. All data were analyzed statistically by mixed models of SAS. Dry fecal output and ATTD of dry matter (DM) and organic matter (OM) were not affected by treatment; however, ATTD of crude protein (CP) was greater (P0.05). Serum triglycerides were within reference ranges, but greater (P<0.05) for dogs fed DC than dogs fed CN or VR, with those fed RM being intermediate. All diets were well tolerated and dogs remained healthy throughout the study. In conclusion, the lightly cooked and raw diets tested were highly palatable, highly digestible, reduced blood triglycerides, and maintained fecal quality and serum chemistry.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-08-01The student, Kiley Algya, accepted the attached license on 2017-07-18 at 12:44.The student, Kiley Algya, submitted this Thesis for approval on 2017-07-18 at 12:54.This Thesis was approved for publication on 2017-07-19 at 13:44.DSpace SAF Submission Ingestion Package generated from Vireo submission #11513 on 2018-03-02 at 13:02:31Made available in DSpace on 2018-03-02T19:59:44Z (GMT). No. of bitstreams: 2
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Previous issue date: 2017-07-19Embargo set by: Seth Robbins for item 105073
Lift date: 2020-03-02T19:59:52Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 105073
Lift date: 2020-03-02T20:02:46Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 105073 on 2020-03-03T10:15:22Z
PLATYPUS: A Multiple—View Learning Predictive Framework for Cancer Drug Sensitivity Prediction
No full textCancer is a complex collection of diseases that are to some degree unique to each patient. Precision oncology aims to identify the best drug treatment regime using molecular data on tumor samples. While omics-level data is becoming more widely available for tumor specimens, the datasets upon which computational learning methods can be trained vary in coverage from sample to sample and from data type to data type. Methods that can 'connect the dots' to leverage more of the information provided by these studies could offer major advantages for maximizing predictive potential. We introduce a multi-view machinelearning strategy called PLATYPUS that builds 'views' from multiple data sources that are all used as features for predicting patient outcomes. We show that a learning strategy that finds agreement across the views on unlabeled data increases the performance of the learning methods over any single view. We illustrate the power of the approach by deriving signatures for drug sensitivity in a large cancer cell line database. Code and additional information are available from the PLATYPUS website https://sysbiowiki.soe.ucsc.edu/platypus
Many Direct-To-Consumer Canine Genetic Tests Can Identify the Breed of Purebred Dogs
No full textOBJECTIVE To compare pedigree documentation and genetic test results to evaluate whether user-provided photographs influence the breed ancestry predictions of direct-to-consumer (DTC) genetic tests for dogs.
ANIMALS 12 registered purebred pet dogs representing 12 different breeds. METHODS Each dog owner submitted 6 buccal swabs, 1 to each of 6 DTC genetic testing companies. Experimenters registered each sample per manufacturer instructions. For half of the dogs, the registration included a photograph of the DNA donor. For the other half of the dogs, photographs were swapped between dogs. DNA analysis and breed ancestry prediction were conducted by each company. The effect of condition (ie, matching vs shuffled photograph) was evaluated for each company’s breed predictions. As a positive control, a convolutional neural network was also used to predict breed based solely on the photograph. RESULTS Results from 5 of the 6 tests always included the dog’s registered breed. One test and the convolutional neural network were unlikely to identify the registered breed and frequently returned results that were more similar to the photograph than the DNA. Additionally, differences in the predictions made across all tests underscored the challenge of identifying breed ancestry, even in purebred dogs.
CLINICAL RELEVANCE Veterinarians are likely to encounter patients who have conducted DTC genetic testing and may be asked to explain the results of genetic tests they did not order. This systematic comparison of commercially available tests provides context for interpreting results from consumer-grade DTC genetic testing kits
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