714 research outputs found
John Frederick Knott - Bibliography from John Frederick Knott. 9 December 1938 — 5 October 2017
No full textJohn Knott was a leading expert in materials, fracture and structural integrity applied particularly to the fields of nuclear power generation and aero-engine applications. He made significant contributions to the quantitative scientific understanding of fracture processes in metals and alloys and its applications in engineering. His early work elucidated the role of microstructure in the initiation and propagation of cracks and involved detailed analysis of the micro-mechanisms of cleavage, ductile and fatigue fracture modes in many types of steel and non-ferrous alloys. He developed innovative techniques of mechanical testing which allowed detailed monitoring of crack propagation. He was the author of a much-used text book on the principles of fracture mechanics.The wide range of his expertise meant that John Knott was in high demand to serve on advisory committees for both government and industry organizations, particularly in the civil nuclear power generation and aerospace industries. With his deep knowledge of materials behaviour, he was invited to give many prestigious lectures at conferences. He was a convivial character with a keen sense of humour and often entertained conference dinners with poems he had composed about the particular event and about other participants
3D Ultrastructure of Synaptic Inputs to Distinct GABAergic Neurons in the Mouse Primary Visual Cortex
No full textSynapses are the fundamental elements of the brain’s complicated neural networks. Although the ultrastructure of synapses has been extensively studied, the difference in how synaptic inputs are organized onto distinct neuronal types is not yet fully understood. Here, we examined the cell-type-specific ultrastructure of proximal processes from the soma of parvalbumin-positive (PV+) and somatostatin-positive (SST+) GABAergic neurons in comparison with a pyramidal neuron in the mouse primary visual cortex (V1), using serial block-face scanning electron microscopy. Interestingly, each type of neuron organizes excitatory and inhibitory synapses in a unique way. First, we found that a subset of SST+ neurons are spiny, having spines on both soma and dendrites. Each of those spines has a highly complicated structure that has up to eight synaptic inputs. Next, the PV+ and SST+ neurons receive more robust excitatory inputs to their perisoma than does the pyramidal neuron. Notably, excitatory synapses on GABAergic neurons were often multiple-synapse boutons, making another synapse on distal dendrites. On the other hand, inhibitory synapses near the soma were often single-targeting multiple boutons. Collectively, our data demonstrate that synaptic inputs near the soma are differentially organized across cell types and form a network that balances inhibition and excitation in the V1.
The Differential Distribution of RAPTA-T in Non-Invasive and Invasive Breast Cancer Cells Correlates with Its Anti-Invasive and Anti-Metastatic Effects
No full textNanoscale secondary ion mass spectrometry (NanoSIMS) combined with transmission electron microscopy (TEM) can be a powerful approach to visualize the exact distribution of drugs at the sub-cellular level. In this work, we exploit this approach to identify the distribution and localisation of the organometallic ruthenium(II)-arene drug Ru((6)-C6H5Me)(pta)Cl-2, termed RAPTA-T, in MDA-MB-231 and MCF-7 human breast cancer cells. These cell lines have been chosen because the former cell lines are highly invasive and resistant to most chemotherapeutic agents and the latter ones are very sensitive to hormonal-based therapies. In the MDA-MB-231 cells, RAPTA-T was found to predominantly localise on the cell membrane and to a lesser extent in the nucleolus. These findings are consistent with the previously reported anti-metastatic properties of RAPTA-T and the observation that once internalized RAPTA-T is associated with chromatin. RAPTA-T shows a lack of membrane accumulation on the non-invasive MCF-7 cells, which correlates well with its selective anti-metastatic properties on invasive cell lines.AHEADLCO
Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey
No full textThe axonal composition of cortical projections originating in premotor, supplementary motor (SMA), primary motor (a4), somatosensory and parietal areas and descending towards the brain stem and spinal cord was characterized in the monkey with histological tract tracing, electron microscopy (EM) and diffusion MRI (dMRI). These 3 approaches provided complementary information. Histology provided accurate assessment of axonal diameters and size of synaptic boutons. dMRI revealed the topography of the projections (tractography), notably in the internal capsule. From measurements of axon diameters axonal conduction velocities were computed. Each area communicates with different diameter axons and this generates a hierarchy of conduction delays in this order: a4 (the shortest), SMA, premotor (F7), parietal, somatosensory, premotor F4 (the longest). We provide new interpretations for i) the well-known different anatomical and electrophysiological estimates of conduction velocity; ii) why conduction delays are probably an essential component of the cortical motor command; and iii) how histological and dMRI tractography can be integrated
People, productivity and performance: the importance of workplace relations reform to Australia's resource future
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After the past decade of unprecedented global investment into new resource projects and existing mine expansions in Australia, the next few years will see a large number of these new mega-projects finish construction and enter the production phase.
During this industry transition, the performance and productivity of Australia's new resource projects will be critical for delivering the greatest returns to the nation and in determining whether more investment capital will find its way into the country.
As Australia's resource industry rapidly transitions into this new long-term production phase, the author, Australian Mines and Metals Association (AMMA) Chief Executive Steve Knott, discusses how leadership, productivity and workplace relations reform will maximise new production capacity and create ongoing opportunities for future generations. In particular, the author explores why Australia's workplace relations system is an increasing concern for an industry subject to intensifying global competition and the reforms that could assist resources companies to do business, invest and create jobs. This extended abstract about all things people and productivity will examine:
Australia's productivity performance against existing and emerging competitors.
The importance of workplace relations for boosting resource industry productivity and positioning Australia to secure further waves of global investment.
Key reform priorities for resource industry employers, and the workplace policy foundations that the industry needs for future productivity and competitiveness.
Labour productivity in the wider context of skills, leadership and technology usage.
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Sleep Deprivation Impairs Productivity in Adults With Mood Disorders: A Scoping Review
No full textAbstract
Date Presented 4/1/2017
Sleep deprivation (SD) is common in adults with mood disorders. Yet, little is known about how SD in adults with mood disorders may further restrict participation in occupations. This scoping review synthesized the literature on the effects of sleep deprivation on the productivity of adults with mood disorders.
Primary Author and Speaker: Melissa Knott
Contributing Authors: Christopher Derak, Lisa McAughey, Rashmi Mehrotra, Florence Roudbarani</jats:p
Miracle in the mundane poems, prompts, and inspiration to unlock your creativity and unfiltered joy
No full text"The national bestselling author of Chasers of the Light pulls back the curtain on his creative process to share how to unlock creativity and lead a more mindful and compassionate life Every day, Tyler Knott Gregson posts romantic and striking poems on Instagram, enchanting his many fans with his authentic and deeply personal voice. He has a remarkable ability to see the beauty within the seemingly mundane moments of our lives, and above all else this is what keeps his fans coming back for more. Tyler's newest book showcases his inspiring poems, but it also goes one step deeper to reveal his secrets to cultivating this sense of wonder for the world. In this insightful guide, you will learn how to uncover your creativity, find inspiration, and live a life that is "more." Through a series of challenges, you are encouraged to write, draw, photograph, and share as you discover how to see yourself in a new way. Featuring exercises on mindfulness and self-expression as well as a poem for every prompt, this book will broaden your heart and mind to see the miracles hidden all around you"--"The national bestselling author of Chasers of the Light pulls back the curtain on his creative process to share how to unlock creativity and lead a more mindful and compassionate life"-
Pandarus rhincodonicus Norman & Newbound & Knott 2000, sp. nov.
No full textPandarus rhincodonicus sp. nov. (®gures 1±5) Material HOLOTYPE: female Western Australian Museum (WAM) C 23238; ALLOTYPE: male WAM C 23239; PARATYPES: WAM C 23240. The senior author holds additional specimens and DRN holds the dissected material. Female (®gures 1±3) Body form shown in ®gure 1A and B. Length range 7.0±8.0 mm (mean = 7.6 mm, n = 10). Width range 3.83±4.28 mm (mean = 4.1 mm, n =10), with greatest width at cephalon, just anterior to the cephalon/thoracic junction. Height range 1.19±1.58 mm (1.4 mm, n =10). Although dorsal surface of body is smooth, pores are scattered across surface. Lateral margins of carapace are ¯eshy and with frill (®gure 2A). Frontal plates well developed and narrow mesial extensions meet in midline. First pediger fused with head; hinder margin of cephalon with four or ®ve robust spines (sometimes heavily eroded), with another two on each extension of the cephalon. Dorsal thoracic plates on pedigers 2±4. Pediger 2: plates separate, extending beyond tip of pediger 3 almost to level of posterior limit of plates of pediger 4; straight posterior margin with four sharp spines. Plates of pediger 3 and 4 fused at their bases; posterior margins with shallow sinuses. Plates of pediger 4 extend over base of genital double somite. Genital double somite: almost circular; with well-de®ned posterior projections (separated by a narrow sinus), each bearing an upturned triangular projection dorsally; often with a sub-marginal setospine either side near base of the sinus (but lacking in the holotype). Abdomen onesegmented covered dorsally by plate longer than wide and not extending to level of tips of caudal rami; margins at the greatest width of dorsal plate curved ventrally, giving the appearance, from dorsal aspect, of a slight projection: ventrally, joined broadly to genital double somite and posteriorly terminating in broad plate extending between bases of caudal rami. Caudal rami stout, curved, L-shaped in cross section; lateral surface is oblique proximally and follows line of abdomen to just beyond the widest point of dorsal abdominal plate beyond which level the caudal ramus is deēcted outwards and tapers to a terminal spine which recurves slightly back towards midline of the animal. Upper margin of caudal ramus is sharply de®ned beyond the stout spine, which marks the beginning of the curve outwards and carries a second smaller spine; ventral surface with tubercle near the proximo-lateral corner and with thin seta and small spine on the mesial edge. Oral area. Adhesion pads present at bases of antennule, antennae and maxillipeds. The surface structure of a pad is illustrated in ®gure 2B and C. Pads also present anteriorly on lateral expansions of thoracomere 2. Antennule (®gure 1C) of two articles: article 1 bearing 27 setospines, 21 stout and six small; article 2 bearing 12 naked, mostly curved, setae. Antenna of three articles (®gure 1D): terminal article bearing large curved terminal spine and two spines marginally; article 2 with two ventral spines, one mid-article on broad base, the other at the distal margin. Mouth tube (®gure 1E): of 10 females measured, oral cones 0.5±1.0 mm long, average 0.7 mm. Labrum ends in complex structure (®gure 2D). Labium with two terminal fringes of backwardly directed denticles (®gure 2D). Mandible (®gure 2D), with slender shaft ¯attened and dentate near the tip. Maxillule (®gure 1F) of two articles: basal article bearing 0 to two short setae; terminal article with large terminal, plus one small spine. Maxilla brachiform (®gure 1G): article 1 (lacertus) unarmed; article 2 (brachium) without ¯abellum, but with two distal spines, longer one fringed, shorter plumose; calamus bearing large claw with rows of spinules and apical patch of spinules. Maxilliped (®gure 1H) of two articles: basal article (corpus maxillipedus) stout with nacreous-like pad; article 2 (subchela) unequally bilobed, with nacreouslike pad, which works against pad of article 1. Legs 1±4 biramose, each ramus of two articles, with spine and setal formula as follows: Arabic numerals: setae. n P: plumose setae. Plumose setae are visible only at high magni®cations. Both rami of legs 1±3 (®gure 3A±C) with two articles. Both rami of leg 4 (®gure 3D) with one article; endopodite lacking spines. Leg 5 (®gure 3E) consisting of outer seta and inner lobe with single terminal spine. Adhesion pads and denticulate areas illustrated in ®gure 3A±D. Figure 2E shows detail of a denticulate region. Egg strings (®gure 3F) slender, approximately same length as body, slightly curved. Eggs disc shaped. Adult females vary in the extent of coloration. Colour patches dark chocolate± chestnut brown centrally shading outwards to transparent amber. Three colour patches occur on the cephalon, one anterior and triangular patches posterio-laterally. The considerable variation in the extent of separation to fusion between these three patches, resulting in considerable variation in the extent of amber-coloured areas about the eye spots, may be due to ontogenetic dierences. Colour patches also occur on frontal lobes; separately on segments 2 and 3 and at the bases of genital lobe projections; across most of segment 4 and abdominal segment (®gure 1A). Male (®gures 4, 5) Body form as in ®gure 4A and B. Length (not including setae on caudal rami) 5.2 ±7.2 mm (mean = 6.0 mm, n =5), width 2.9±4.3 mm (mean = 3.3 mm, n = 5) and height 0.84±0.94 mm (mean = 0.90, n = 5). Cephalon rounded when viewed dorsally with head and ®rst pediger fused. Segment 2 bears two pairs of dorsal spines; segments 3, 4 and 5 each bear one pair of dorsal spines. Pedigers 2± 4 free, without dorsal plates except for lateral wing-like plates on pediger 2. Genital double somite with posterior corners terminating in prominent triangular projection. Coiled spermatophores visible within genital double somite. Abdomen two-segmented. Caudal ramus bearing four long, plumose setae and series of ®ne setules along inner margin. Oral area as in female except for distribution of adhesion pads. Adhesion pad (®gure 4B) present at base of antennule (®gure 4C) approximatel y half the length, and positioned at greater angle towards centre of the cephalon, than is the case in the female. Small adhesion pad situated on base of antenna (®gure 4D). Absence of adhesion pads at base of maxilliped (®gure 4E) and on lateral projections of pediger 2. Legs 1±4 biramose, each ramus of two articles, with spine and setal formula as follows: Arabic numerals: setae. n P: plumose setae. Three sizes of setae are recognizable on the legs as follows: gigantic setae on article 1 of endopods 2±4; one very large, bipennate setae on article 1 of exopods 2 and 3 and three to eight setae on article 2 of all exopod and endopods; and smaller setae on both articles of exopods 1±4. Legs 1±4, ®gures 5A-D, which show the distribution of adhesion pads and denticulate areas. Leg 5 borne on genital double somite as lateral projection with three setae and one stout terminal spine. Leg 6 consisting of two setospines, outer longer than inner, borne on genital double somite near the origin of the abdomen. Colour in life is pale pink and devoid of darker pigment. Etymology Rhincodonicus refers to the host of the copepods, the whale shark, Rhincodon typus.Published as part of Norman, B. M., Newbound, D. R. & Knott, B., 2000, A new species of Pandaridae (Copepoda), from the whale shark Rhincodon typus (Smith), pp. 355-366 in Journal of Natural History 34 (3) on pages 357-364, DOI: 10.1080/002229300299534, http://zenodo.org/record/475739
Blueberry Ridge School District No. 4562 - 03
No full textPhotograph - Pupils at a school concert at Blueberry Ridge School near Rochester, Alberta. Left to right: Teacher, Miss Taylor, and students, Ethel Hurley, Ruby Hicks, Arnold Knott, Ann Lukeski, Ruth Ward, Mary Wilson, Alex Panalack, Ernst Hahn, Eva Hurley and Kenneth WardTaylor, Miss; Hurley, Ethel; Hicks, Ruby; Knott, Arnold; Lukeski, Ann; Ward, Ruth; Wilson, Mary; Panalack, Alex; Hahn, Ernst; Hurley, Eva; Ward, Kennet
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