1,720,999 research outputs found
Siblings' perspectives on their relationships with a brother or sister with autism
No full textThis study compared adjustment and quality of relationship in siblings of adolescents and young adults with Autism Spectrum Disorder (ASD; n = 27) and siblings with typical development (n = 27). Siblings completed the Network of Relationships Inventory-Behavioral Systems Version and Symptom Checklist-90-R. Only for siblings of adolescents and young adults with ASD, we conducted in-person semi-structured interviews for evaluating the sibling relationship in terms of similarity and differences, siblings' demands, and feelings. Results demonstrated that the two groups showed different emotional relationship and adjustment. A qualitative survey lead to several interesting suggestions to plan support's projects for adolescents siblings and young adults. The findings of this study emphasize the importance of carefully considering the domains included in future research on individual's psychological well-being and quality of sibling relationship for planning intervention programs siblings of adolescents and young adults with Autism Spectrum Disorder
Tyrosinase Expression as a Molecular Marker for Investigating the Presence of Circulating Tumor Cells in Melanoma Patients
No full textIn 1991, Reverse Transcriptase–Polymerase Chain Reaction (RT-PCR) was introduced to assess the expression
of Tyrosinase in the peripheral blood of melanoma patients, in order to identify the presence of Circulating Melanoma
Cells. To date, hundreds of studies, some of which are reviewed here, were performed to assess the clinical value of tyrosinase
expression alone, and/or, in addition to other molecular markers. Unfortunately no consensus on the utility of tyrosinase
detection exists. In this paper, we underline the presence of too many variables that may interfere with the detection
of circulating melanoma cells: from withdrawal and RNA extraction, to Reverse Transcriptase–Polymerase Chain
Reaction and the assays used for the analysis of amplification products
ABCB5 in peripheral blood of a patient affected by multiple primary malignancies
No full textLa sindrome da neoplasie multiple è caratterizzata dall’insorgenza di diversi tumori in maniera sincroma in un organismo. Il caso da noi riportato ha evidenziato la presenza di sei diverse neoplasie primarie nell’arco di quattro anni. Il paziente è stato affetto da adenocarcinoma prostatico, carcinoma duttale mammario, linfoma (CD 20+), due melanomi indipendenti e un basalioma. È stata, quindi, effettuata la ricerca di marker di staminalità nel sangue periferico e nei linfonodi sentinella, dimostrando la presenza del recettore ABCB5, tipico del melanoma
EpCAMlow circulating tumor cells: Gold in the waste
Full text linkThe CellSearch® system which is still considered the gold standard for the enumeration of circulating tumor cells (CTC) utilizes antibodies against the epithelial cell adhesion molecule (EpCAM) for CTC enrichment. Recently, CTC discarded by the CellSearch® system due to their low EpCAM expression have been isolated and analyzed. We here sought to discuss technical and biological issues concerning the isolation and characterization of EpCAMlow CTC, highlighting the enormous potential of this subpopulation discarded by CellSearch®, which might instead reveal an unexpected clinical significance in tumor types where CTC enumeration has never been validated for prognostic and predictive purpose
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Internalizing and externalizing behaviors and close relationships in siblings of adolescents with autism spectrum disorder
No full textThe literature on typically developing (TD) siblings of individuals with Autism Spectrum Disorder (ASD-TD siblings) has grown over the last few decades, providing inconsistent results. Much attention has been reserved to sibling relationships when one shows ASD symptoms. The purpose of the current study was to examine the mutual influences between ASD-TD siblings' emotional and behavioral characteristics, as evaluated by mothers, and the different dimensions of the sibling relationship through the lens of the behavioral system model Specifically, the role of ASD-TD siblings' emotional and behavioral functioning on sibling relationship was investigated. We hypothesized that the presence of internalizing and externalizing behaviors in ASD-TD siblings may be associated with less support, more negative interactions, and conflict in the sibling relationship. The sample included 59 ASD-TD siblings (35 M and 24 F; age range: 11-18 years, M = 14.20, SD = 1.52) of adolescents with ASD and their mothers. Behavioral and emotional characteristics of ASD-TD siblings showed significant associations with sibling relationship dimensions. Specifically, support was negatively and significantly related to externalizing behavior, whereas conflict was positively related to internalizing behavior. Additionally, externalizing and internalizing behaviors showed a predictive role: Externalizing behavior emerged as a significant negative predictor of support and internalizing behavior emerged as a significant positive predictor of negative interaction
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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