7 research outputs found
Apocrine papillary cystadenoma and basal cell carcinoma: an unusual collision tumor.
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Can a single drug administration elicit two different immunological pathways at the same time? A case report of Fixed Drug Eruption after anaphylaxis
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A single institute's experience on melanoma prognosis: A long-term follow-up
No full textBACKGROUND: The prognosis of cutaneous melanoma is correlated to histopathologic parameters such as Breslow thickness, the presence of mitosis, ulceration and lymphatic involvement at the moment of the diagnosis. On the other hand, the prognostic value of parameters such as age, sex, and tumor localization are still a matter of debate. We evaluated herein the prognostic factors in melanoma patients during a long-term follow-up (60 months). METHODS: Melanoma patients presenting stage IB-III at diagnosis were included. Breslow thickness, ulceration, lymphatic involvement, patients' age, sex and tumor localization were correlated to patients' prognosis. Univariate Cox regressions and multivariate Cox proportionalhazards regression were performed. Successively, Kaplan-Meier was used for variables significantly associated with overall melanoma survival. RESULT S: A total of 115 melanoma patients were included in this study. During follow-up 82 (72.17%) patients survived and 33 (28.7%) died. In our dataset, Breslow thickness >2 mm (P=0.0007), patients age >50 years (P=0.005) and positive sentinel lymph node (P=0.0003) seem to be the most important variables correlated with the presence of metastases at 5 years follow-up. However distant metastases were also observed during follow-up in 14/26 patients presenting negative sentinel lymph node at diagnosis. CONCLUSIONS: Given the vital importance of target drugs and the newly introduced immunotherapies in cutaneous melanoma management, we would suggest that mutational analyses should also be extended to the subgroup of patients presenting microstaging parameters related to a poor prognosis in a long-term follow-up of 60 months
Drug consumption and melanocytic nevi: correlation between oral contraceptives or hormone replacement therapy and a high melanocytic nevi count
No full textUn ILS open source per l'automazione delle biblioteche: l'ipotesi Koha a Ca' Foscari.
No full textThe first part of the work is focused on the history and last trend on library automation and integrated library systems, with specific attention on the italian context. The second part introduce to open source, evaluates some possible use of open source software in library and open source diffusion in Italy. The third part analyze Koha, an open source ILS, and its possible application at the University of Ca' Foscari Library System
