30 research outputs found
Risk Factors in Addition To Short and Long-Term Outcomes With Thin Catheter Surfactant Administration Failure in Preterm Infants: a Retrospective Analysis
No full textKanmaz Kutman, H. Gozde/0000-0002-3177-9411; Siyah Bilgin, Betul/0000-0003-3807-4809; Kadioglu Simsek, Gulsum/0000-0003-4831-8950Objective: To evaluate the incidence of thin catheter surfactant administration (TCA) failure and compare short and long-term neonatal outcomes who failed TCA or did not. Design: Single-center retrospective cohort study. Infants between 25 and 30 weeks of gestational age with respiratory distress syndrome and receiving 200 mg/kg poractant alfa via thin catheter administration were included. TCA failure was defined as the need for early mechanical ventilation ( 72 h). Infants were divided into two groups those who failed TCA or those who did not. Results: The TCA failure rate was 24.6%. Initial oxygen requirement (0.39% vs. 0.36%) and the number of small for gestational age infants were significantly higher in the TCA failure group (15% vs. 7.9%). Infants who failed TCA had a higher pneumothorax (6.7% vs. 1.1%, p = 0.03), BPD (15% vs.5.5%, p = 0.02), late-onset sepsis (36.7% vs. 18%, p = 0.04), retinopathy of prematurity rates (11.7% vs. 3.3%, p = 0.02) and an increased duration of respiratory support. However, Bayley Scales of Infant Development II scores were comparable between groups at 18 and 26 months of corrected age. Conclusion: Infants who fail TCA are at increased risk for short-term complications despite favourable long-term neurodevelopmental outcomes. Identifying infants at risk of TCA failure may help early prevention of morbidities and individualise their management
Turkish Neonatal Society guideline on the management of respiratory distress syndrome and surfactant treatment
No full textRespiratory distress syndrome is the leading cause of respiratory failure in preterm infants. The incidence and severity of respiratory distress syndrome are inversely related to the gestational age of the newborn. The major underlying pathophysiologic mechanisms are surfactant deficiency and anatomic, structural immaturity of the lung. Recent improvements such as antenatal steroid treatment to enhance pulmonary maturity, appropriate resuscitation facilitated by placental transfusion and immediate use of continuous positive airway pressure for alveolar recruitment, early rescue administration of surfactant, ventilation with gentler modes to minimize damage to the immature lungs, and the other supportive therapies have significantly decreased respiratory distress syndrome-related morbidity and mortality. This guideline was addressed to overview the mentioned improvements in order to standardize respiratory distress syndrome management in neonatal intensive care units in Turkey
Turkish Neonatal Society guideline on the management of respiratory distress syndrome and surfactant treatment
No full textExamination of Circassian proverbs mentioned in Mashbas İshak's novels translated into Turkish, they are "Bitmeyen Umutlar I-II, Taşdeğirmen, Sürülenler ve Hehesher"
Get PDFYÖK Tez No: 652340Dil, bir toplumun en değerli kültürel mirasıdır. Dilde kullanılan kelimeler, atasözleri ve deyimler o toplumun yaşam biçimini, tarihini ve kültürünü yansıtır. Bu nedenle dilin devamlılığını sağlamak, dildeki kullanımların yozlaşmasını engellemek, o toplumun kültürünü korumak demektir. Bu çalışmada ele alınan Çerkez atasözleri de Çerkez kültürünün devamlılığının sağlanması ve korunması amacıyla ele alınmış ve çalışmayla ataların kültürü gelecek nesle aktarılmak istenmiştir. Bu amaç doğrultusunda kültürel öğelere eserlerinde çokça rastladığımız Çerkez Edebiyatı'nın ünlü yazarı Meşbaşe İshak'ın eserleri kullanılan atasözleri açısından incelenmiştir.Language is the most valuable cultural heritage of a society. Words, proverbs and idioms used in language reflect the life style, history and culture of that society. Therefore, to ensure the continuity of the language, and to prevent the corruption of the use of the language means to protect the culture of that society. The Circassian proverbs discussed in this study were also discussed in order to ensure the continuity and preservation of the Circassian culture. For this purpose, cultural elements were examined in terms of proverbs used in the works of Meshbas, Ishaq, the esteemed author of Circassian literature, which we have come across in many of his works
Sex-Specific Effects of Nutritional Supplements for Infants Born Early or Small: An Individual Participant Data Meta-Analysis (ESSENCE IPD-MA) I—Cognitive Function and Metabolic Risk
Get PDFNeonatal nutritional supplements are widely used to improve growth and development but may increase risk of later metabolic disease, and effects may differ by sex. We assessed effects of supplements on later development and metabolism. We searched databases and clinical trials registers up to April 2019. Participant-level data from randomised trials were included if the intention was to increase macronutrient intake to improve growth or development of infants born preterm or small-for-gestational-age. Co-primary outcomes were cognitive impairment and metabolic risk. Supplementation did not alter cognitive impairment in toddlers (13 trials, n = 1410; adjusted relative risk (aRR) 0.88 [95% CI 0.68, 1.13]; p = 0.31) or older ages, nor alter metabolic risk beyond 3 years (5 trials, n = 438; aRR 0.94 [0.76, 1.17]; p = 0.59). However, supplementation reduced motor impairment in toddlers (13 trials, n = 1406; aRR 0.76 [0.60, 0.97]; p = 0.03), and improved motor scores overall (13 trials, n = 1406; adjusted mean difference 1.57 [0.14, 2.99]; p = 0.03) and in girls not boys (p = 0.03 for interaction). Supplementation lowered triglyceride concentrations but did not affect other metabolic outcomes (high-density and low-density lipoproteins, cholesterol, fasting glucose, blood pressure, body mass index). Macronutrient supplementation for infants born small may not alter later cognitive function or metabolic risk, but may improve early motor function, especially for girls
Alkaline phosphatase levels of preterm infants under 30 weeks of gestational age and its role in the diagnosis of osteopenia of prematurity
No full textAim: Alkaline phosphatase is perhaps the most important biochemical marker used in the diagnosis and follow-up of metabolic bone disease or osteopenia of prematurity (OP). The aim of this study was to investigate the percentiles of alkaline phosphatase (ALP) levels in premature infants compared to gestational age and to determine cut-off values for the diagnosis of osteopenia.Material Methods: All ALP results sent to our biochemistry laboratory between 2013-2018 were evaluated retrospectively. Of the total 2476 results, 1830 (74%) were found to belong to a separate infant born before 30 weeks of gestation. The results and demographic data of the patients whose clinical information could be reached were statistically analyzed.Results: The mean birth weight of the infants included in the study was 995 g±254 (450-1500 g) and the mean gestational week was calculated as 27±1.7 (24-29,6 weeks). The average alkaline phosphatase level was 510±225 U/L [median: 458 IU/L (159-1554)]. In serum ALP levels; 160.8 IU/L value 5. Percentile, 203 IU/L 10. percentile, 290 U/L 25. percentile 421 IU/L 50. percentile, 583 U/L 75. Percentile, 819 U/L formed 90th percentile and 969 U/L formed 95th percentile. Separate percentiles were also calculated for each gestational week interval.Conclusion: Although the infants included in the study were hospitalized premature infants, this is the reference range study with the largest number of patients in our country. Although the data is retrospective, these percentiles may be helpful in the evaluation and the diagnosis of osteopenia in premature infants.Keywords: Preterm infant; alkaline phosphatase; osteopenia; phosphorus
The association between early partial carbondioxide levels and neurodevelopmental outcomes of very preterm infants
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