1,407 research outputs found
Correction: Efects and mechanisms of supramaximal high-intensity interval training on extrapulmonary manifestations in people with and without chronic obstructive pulmonary disease (COPD-HIIT): study protocol for a multi-centre, randomized controlled trial
No full textFollowing the publication of the original article [1], we were notified that the formatting in Table 3 was incorrect. Additionally, a few numbers have been mistakenly formatted as references throughout the text and these have been removed. The original article has been corrected.</p
The effect of aerobic exercise training on intrinsic satellite cell function in healthy older adults: a pilot study
No full textSupplemental tables and figures to the manuscript titled "The effect of aerobic exercise training on intrinsic satellite cell function in healthy older adults: a pilot study" published in the Journal of Applied Physiology-Regulatory, Integrative and Comparative Physiology
Ideas for justice
No full textAs part of the wider ‘What is Justice?’ symposium, the Ideas for Justice project is speaking to people about their understanding and experience of justice today. The interviews are being conducted by Harry Annison and Philippa Budgen. In this update on the ‘Ideas for Justice’ project, we reflect on the interviews that have been published so far
The margin and the mainstream : positioning Harry Partch's theories within the broader discourse of musical aesthetics
No full textBibliography: leaves 102-106.The dissertation examines the broader musical value of microtonal composer Harry Partch's musical theories by locating his critique of abstract music within mainstream compositional theory and aesthetics. This contextualisation aims to deconstruct Partch's iconoclastic image so as to understand his contribution within a wider realm of critical discourse. The work of composers that follow in Partch's footsteps becomes important in this context, especially that of his one-time student Ben Johnston whose own microtonal aesthetic is firmly rooted in European aesthetics from Debussy to Schoenberg. By a study of Johnston's utilisation of Partch's theory of just intonation the dissertation attempts to arrive at a more inclusive compositional theory, one which continues to address those aspects of Partch's theories that serve as a valid and constructive critique of traditional musical values. Taking Adorno's view that musical critique must deal with the problem of reification at the level of musical materials, the author proposes a reading of Partch's corporeal philosophy that is applicable beyond the confines of narrative musical drama. By creating a distinction between historical models of organisation and 'second nature' forms of musical presentation, it is suggested that critique does not necessarily prefigure alienation from the mainstream, but can rather be situated within musical discourse in such a way that a new image of the latter's forms results. On a practical level, the dissertation explores the validity of expanded just intonation as a means of achieving this immanent critique, both in the realm of compositional theory and, implicitly, in that of analytical theory, concluding with the description of a tuning system with the capacity to synthesise the range of compositional theories explored
Effects and mechanisms of supramaximal high-intensity interval training on extrapulmonary manifestations in people with and without chronic obstructive pulmonary disease (COPD-HIIT):study protocol for a multi-centre, randomized controlled trial
No full textBACKGROUND: Beyond being a pulmonary disease, chronic obstructive pulmonary disease (COPD) presents with extrapulmonary manifestations including reduced cognitive, cardiovascular, and muscle function. While exercise training is the cornerstone in the non-pharmacological treatment of COPD, there is a need for new exercise training methods due to suboptimal adaptations when following traditional exercise guidelines, often applying moderate-intensity continuous training (MICT). In people with COPD, short-duration high-intensity interval training (HIIT) holds the potential to induce a more optimal stimulus for training adaptations while circumventing the ventilatory burden often associated with MICT in people with COPD. We aim to determine the effects of supramaximal HIIT and MICT on extrapulmonary manifestations in people with COPD compared to matched healthy controls. METHODS: COPD-HIIT is a prospective, multi-centre, randomized, controlled trial with blinded assessors and data analysts, employing a parallel-group designed trial. In phase 1, we will investigate the effects and mechanisms of a 12-week intervention of supramaximal HIIT compared to MICT in people with COPD (n = 92) and matched healthy controls (n = 70). Participants will perform watt-based cycling two to three times weekly. In phase 2, we will determine how exercise training and inflammation impact the trajectories of neurodegeneration, in people with COPD, over 24 months. In addition to the 92 participants with COPD performing HIIT or MICT, a usual care group (n = 46) is included in phase 2. In both phases, the primary outcomes are a change from baseline in cognitive function, cardiorespiratory fitness, and muscle power. Key secondary outcomes include change from baseline exercise tolerance, brain structure, and function measured by MRI, neuroinflammation measured by PET/CT, systemic inflammation, and intramuscular adaptations. Feasibility of the interventions will be comprehensively investigated. DISCUSSION: The COPD-HIIT trial will determine the effects of supramaximal HIIT compared to MICT in people with COPD and healthy controls. We will provide evidence for a novel exercise modality that might overcome the barriers associated with MICT in people with COPD. We will also shed light on the impact of exercise at different intensities to reduce neurodegeneration. The goal of the COPD-HIIT trial is to improve the treatment of extrapulmonary manifestations of the disease. TRIAL REGISTRATION: Clinicaltrials.gov: NCT06068322. Prospectively registered on 2023-09-28
Memo from Harry L. Black, Assistant Project Director, to Willard E. Schmidt, Chief of Police, re: disorders in Block #54, June 2, 1944
No full textDiscusses imprisonment in the stockade of 12 incarcerees and tension concerning the Japanese Language Schools and the schools in the camps, detailing what it terms "terrorist tactics" on the part of the Japanese Language School's proponents and concluding that the Project Director is justified in using the stockade for disciplinary purposes. The document also includes the directive, Administration of Japanese Language Schools at Tule Lake incarceration camp (March 30, 1944 by R. R. Best, Project Director), which outlines policy regarding the camp and Japanese Language Schools; a memo regarding this directive "prepared as a public announcement by Mr. Harkness, Superintendent of Schools... (May 18, 1944);" and a memo from Kenneth M. Harkness, Superintendent of Schools, to Harry L. Black, Chief, Community Management (May 21, 1944) concerning these memoranda. Also included is an envelope from the Federal Communications Commission to Willard E. Schmidt marked Personal and Confidential.The Willard Schmidt collection, documents some of the administrative duties of Willard Schmidt, the Chief of Internal Security for the War Relocation Authority and the Tule Lake incarceration/segregation camp. This collection contains administrative records and photos documenting the Tule Lake camp, the largest incarceration camp with a peak population of 18,789 and with the most turbulent history. In 1943, the camp was turned into a segregation center to house "disloyal" Japanese Americans relocated from other camps based on their answers to a confusing loyalty questionnaire. The camp endured martial law from November 1943- Jan 1944 after escalating protests and unrest. The hostile environment of the camp lead to many incarcerees renouncing their American citizenship upon the end of incarceration, a process which took 14 years to reverse if they did not wish to be deported to Japan
Skeletal muscle mitophagy in chronic disease: implications for muscle oxidative capacity?
Full text linkPurpose of reviewLoss of skeletal muscle oxidative capacity is a common feature of chronic diseases such as chronic obstructive pulmonary disease, type 2 diabetes, and congestive heart failure. It may lead to physical impairments and has been suggested to contribute to metabolic inflexibility-induced cardiometabolic risk. The mechanism underlying loss of muscle oxidative capacity is incompletely understood. This review discusses the role of mitophagy as a driving force behind the loss of skeletal muscle oxidative capacity in these patients.Recent findingsMitophagy has been studied to a very limited extent in human skeletal muscle. There are, however, clear indications that disease-related factors, including hypoxia, systemic inflammation, muscle inactivity, and iron deficiency are able to induce mitophagy, and that these factors trigger mitophagy via different regulatory mechanisms. Although mitophagy may lead to mitochondrial loss, it is also required to maintain homeostasis through clearance of damaged mitochondria.SummaryBased on available evidence, we propose that enhanced mitophagy is involved in chronic disease-induced loss of muscle oxidative capacity. Clearly more research is required to confirm this role and to establish to what extent mitophagy is pathological or a part of physiological adaptation to maintain muscle health
Memo from Harry L. Black, Advisory Committee, to Mr. [Raymond R.] Best, February 8, 1944
No full textMemorandum regarding meeting with Co-ordinating Committee. Concerns meeting to discuss Committee's recommendation to release "18 additional detainees from the stockade." The memo on "Executive Office of the President, Office for Emergency Management" letterhead, also discusses employment of incarcerees from Manzanar and Tule Lake and moving incarcerees out of and into various housing blocks.The Willard Schmidt collection, documents some of the administrative duties of Willard Schmidt, the Chief of Internal Security for the War Relocation Authority and the Tule Lake incarceration/segregation camp. This collection contains administrative records and photos documenting the Tule Lake camp, the largest incarceration camp with a peak population of 18,789 and with the most turbulent history. In 1943, the camp was turned into a segregation center to house "disloyal" Japanese Americans relocated from other camps based on their answers to a confusing loyalty questionnaire. The camp endured martial law from November 1943- Jan 1944 after escalating protests and unrest. The hostile environment of the camp lead to many incarcerees renouncing their American citizenship upon the end of incarceration, a process which took 14 years to reverse if they did not wish to be deported to Japan
Manners cost nothing? Civility on Twitter and political engagement, trust, and affective polarisation in Britain
No full textThis data set was created for the purpose of Harry Gable's 2020 MPhil thesis (Politics, Comparative Government) that has been deposited under the same title. It was created by relation to a Qualtrics online survey, which was completed by participants between 26 November and 1 December 2019. Participants were recruited using the online subject recruitment platform Prolific. The author recommends using the statistical analysis software R to analyse the data contained within the Excel spreadsheet
Manners cost nothing? Civility on Twitter and political engagement, trust, and affective polarisation in Britain
Full text linkThis data set was created for the purpose of Harry Gable's 2020 MPhil thesis (Politics, Comparative Government) that has been deposited under the same title. It was created by relation to a Qualtrics online survey, which was completed by participants between 26 November and 1 December 2019. Participants were recruited using the online subject recruitment platform Prolific. The author recommends using the statistical analysis software R to analyse the data contained within the Excel spreadsheet
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