102,530 research outputs found
[New strategies in the treatment of acute myocardial infarction]. FT Nuove strategie di trattamento dell'infarto miocardico acuto
No full textI lavori della Costituente: DC, PCI e gli altri schieramenti politici di fronte alla questione della "scuola di tutti"
No full textUna scuola per la nuova Italia. I lavori della Costituente: DC, PCI e gli altri schieramenti politici di fronte alla questione della 'scuola di tutti'
No full textIl lavoro prende in esame le posizioni dei principali partiti politici in merito al riordino del sistema scolastico dopo il ventennio fascista. I problemi relativi all’insegnamento religioso, al finanziamento della scuola privata, al diritto allo studio troveranno – dopo molteplici scontri tra gli opposti schieramenti – una soluzione compromissoria nell’elaborazione degli articoli costituzionali favorevoli ad una scuola democratica e aperta a tutti
Invasive coronary revascularisation is better than conservative treatment in patients with acute coronary syndromes
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Dizziness and syncope in young people: keep yourmind open! Case report of the challenging differentiation between arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) and catecholaminergic polymorphic ventricular tachycardia (CPVT).
No full textA paradigmatic case of aborted sudden cardiac death (SCD) in a young man is discussed, mirroring the challenge of diagnosing the various conditions potentially underlying this dramatic condition. Based on the clinical characteristics of our case, presenting some overlapping clinical features common to both the diseases, the discussion will be focused on Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) and Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia (ARVC/D). Epidemiological, genetic, diagnostic and therapeutic aspect will be discussed
The dark side of the QT interval. The Short QT Syndrome: pathophysiology, clinical presentation and management.
No full textA large number of studies has been carried out to investigate the pathophysiology and the clinical implications of QT interval prolongation in the ECG over recent years. It was only in the last decade, however, that the scientists have focused on the specular aspects of the long QT syndrome (LQTS), and it is now well established that the abnormal shortening of the QT interval is associated with meaningful clinical consequences and adverse outcomes.
The aim of the present article is to summarize knowledge and existing evidence about the Short QT Syndrome (SQTS). SQTS is a rare, albeit largely underdiagnosed, genetically determined disease, which is characterized by a high tendency to develop life-threatening arrhythmias. The two clinical landmarks of SQTS are the presence of a short QT interval (i.e., less than 320 ms) in a structurally normal heart. The disease is now classified as a “channellopathy”, and is principally caused by a defective functioning of both potassium and calcium ion channels. The underlying genetic anomalies cause an abnormal ripolarization and a reduced refractoriness of myocardiocites. Pharmacologic treatments are mainly tailored to slow the conduction and to prolong the refractory period of myocardiocites. The implantable cardioverter and defibrillator (ICD) is currently considered the therapeutic gold standard
Hemodynamic, respiratory, and metabolic effects of medium-chain triglyceride-enriched lipid emulsions following valvular heart surgery
No full textStudy: A lipid emulsion containing 10 percent medium-chain triglycerides (MCT) and 10 percent long-chain triglycerides (LCT) was infused at a rate of 1 ml/kg/h (3.3 mg/kg/min) for 2 h, in 12 patients (2 males, 10 females; mean age, 54 ± 3 (SEM) years; range, 34 to 67 years) 24 h after open-heart surgery (mitral valve replacement). Methods: Hemodynamic factors (pulmonary and radial artery indwelling catheters), oxygen and carbon dioxide partial pressures, oxygen saturation, oxygen delivery and consumption, and intrapulmonary shunt fraction were obtained before, during, and after lipid infusion (for 2 h), at 30-s intervals, along with some metabolic indexes (triglycerides, free fatty acids, glucose, insulin, lactate, acetoacetate). Results: No statistically significant changes in heart rate, cardiac index, systemic and pulmonary pressures and resistances, central venous and pulmonary capillary pressures, or arterial oxygen partial pressure were observed during infusion. Arterial carbon dioxide partial pressure values were constantly reduced throughout and after the end of lipid infusion, as compared with baseline values, while oxygen consumption was increased significantly without any change in oxygen delivery. No adverse effects on intrapulmonary shunt fraction were observed. Statistically significant increases of triglycerides, free fatty acids, acetoacetate and insulin (peak values at end of the lipid infusion) were found in comparison with baseline values. Plasma glucose increased significantly during lipid infusion and remained higher than baseline values until the end of the study. Lactate levels were unchanged, except for a slight decrease at the end of the study, without any derangement of acid-base equilibrium. Neither arrhythmias nor adverse clinical reactions were observed as a consequence of lipid infusion. Conclusion: Fat emulsions containing both MCT and LCT, when given at 3.3 mg/kg/min for 120 min following valvular heart surgery, do not exert negative cardiopulmonary effects, and could represent a source of rapidly metabolized substrates
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