177 research outputs found
Effects of environment and genotype on hardness and alkaline cooking properties of maize / by Troy Marc Goldstein
No full textDue to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Bibliography: leaves 73-77.Not availabl
Accretion: Flexible, Networked Animated Music Notation For Orchestra With the Raspberry Pi
No full textIn 2014, the author set out to expand the notational potential of their generative music systems to be performed by the Rensselaer Orchestra in Troy, NY. The experiments resulted in the use of several networked Raspberry Pi devices delivering a realtime, generative Animated Music Notation to subsections of the live orchestra during performance. This paper outlines the structure of the piece, Accretion; the technical details of its implementation; and the possibilities presented by using the Raspberry Pi to deliver scored materials to performers. Ultimately, the paper seeks to make a case for adopting the Raspberry Pi as a powerful device and method of distribution/performance of Animated Music Notation
Episodis de matèria troiana en el manuscrit espagnol 13 de la Bibliothèque nationale de France
No full textThis article focuses on the episodes related to the matter of Troy included in the manuscript Espagnol 13 of the Bibliothèque nationale de France (Paris) that contains, among other texts, a fifteenth century Catalan translation of Histoire ancienne jusqu’à César, the great universal chronicle written in the early thirteenth century and attributed to Wauchier de Denain. Some considerations about the main features of the underlying model of this translation are singled out, and the most relevant features of the text are also analysed. Unlike the other Catalan translation of the Histoire ancienne jusqu’à César that has come down to us (Ms. 352, in Biblioteca de Catalunya), this version does not offer a full translation of the Trojan section of the Histoire ancienne jusqu’à César, but of just a few passages, those that seemed to be more interesting for the author/compiler. Thus, some hypotheses are offered -the knowledge of the Historia destructionis Troiae, Guido delle Colonne’s latin version, or maybe of the other Catalan version- in order to explain why this Catalan translation is missing the core of the story, precisely the most narrative section with all the details and circumstances of the Trojan War. The study is completed with the edition in an appendix of those episodes related to the matter of Troy, so far unpublished, of this Catalan version of the great French universal chronicle.Aquest treball s’ha dut a terme en el marc del projecte d’investigació “BITECA y su contexto literario (occitano y latín). De los manuscritos al mundo digital” (FFI2014-55537-C3-1-P), finançat pel Ministeri d’Economia i Competitivitat (Secretaria d’Estat d’Investigació, Desenvolupament i Innovació), amb participació de fons FEDER, i dirigit per la Dra. Gemma Avenoza (UB - IRCVM) i el Dr. Xavier Espluga (UB)
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Reply to comment by Keith J. Beven and Hannah L. Cloke on "Hyperresolution global land surface modeling: meeting a grand challenge for monitoring Earth’s terrestrial water"
No full textMonitoring Earth's terrestrial water conditions is critically important to many hydrological applications such as global food production; assessing water resources sustainability; and flood, drought, and climate change prediction. These needs have motivated the development of pilot monitoring and prediction systems for terrestrial hydrologic and vegetative states, but to date only at the rather coarse spatial resolutions (∼10–100 km) over continental to global domains. Adequately addressing critical water cycle science questions and applications requires systems that are implemented globally at much higher resolutions, on the order of 1 km, resolutions referred to as hyperresolution in the context of global land surface models. This opinion paper sets forth the needs and benefits for a system that would monitor and predict the Earth's terrestrial water, energy, and biogeochemical cycles. We discuss six major challenges in developing a system: improved representation of surface-subsurface interactions due to fine-scale topography and vegetation; improved representation of land-atmospheric interactions and resulting spatial information on soil moisture and evapotranspiration; inclusion of water quality as part of the biogeochemical cycle; representation of human impacts from water management; utilizing massively parallel computer systems and recent computational advances in solving hyperresolution models that will have up to 109 unknowns; and developing the required in situ and remote sensing global data sets. We deem the development of a global hyperresolution model for monitoring the terrestrial water, energy, and biogeochemical cycles a “grand challenge” to the community, and we call upon the international hydrologic community and the hydrological science support infrastructure to endorse the effort
Trade remedies and World Trade Organization dispute settlement : Why are so few challenged?
No full textAntidumping and related trade remedies are the most popular policy instruments that many of the largest importing countries in the World Trade Organization (WTO) system use to restrict international trade. While such trade remedies are also frequent targets of dispute settlement activity under the WTO, given that Panel and Appellate Body rulings have almost invariably found that some aspect of each reviewed remedy was inconsistent with WTO obligations, an open research question is why aren't more remedies targeted by dispute settlement? The author provides a first empirical investigation of the trade remedy and WTO dispute settlement interaction by focusing on determinants of WTO members'decisions of whether to formally challenge U.S. trade remedies imposed between 1992 and 2003. He provides evidence that it is not only the size of the economic market at stake and the capacity to retaliate under potential DSU (dispute settlement understanding)-authorized sanctions that influence the litigation decision of whether to formally challenge a measure at the WTO. The author also finds that if the negatively affected foreign industry has the capacity to directly retaliate through a reciprocal antidumping investigation and measure of its own, its government is less likely to pursue the case on its behalf at the WTO. This is consistent with the theory that potential complainants may be avoiding WTO litigation in favor of pursuing reciprocal antidumping and hence"vigilante justice."TF054105-DONOR FUNDED OPERATION ADMINISTRATION FEE INCOME AND EXPENSE ACCOUNT,Economic Theory&Research,Trade and Services,World Trade Organization,Trade Policy
Preparation of low molecular weight heparin from a remodeled bovine intestinal heparin
No full textJournal of Medicinal Chemistry, 64, 2242-2253Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.Bovine intestinal heparins are structurally distinct from porcine intestinal heparins and exhibit lower specific anticoagulant activity (units/mg). The reduced content of N-sulfo, 3-O-sulfo glucosamine, the central and critical residue in heparin’s antithrombin III binding site, is responsible for bovine intestinal heparin’s reduced activity. Previous studies demonstrate that treatment of bovine intestinal heparin with 3-O-sulfotransferase in the presence of 3′-phosphoadenosine-5′-phosphosulfate afforded remodeled bovine heparin with an enhanced activity reaching the United States Pharmacopeia’s requirements. Starting from this remodeled bovine intestinal heparin, we report the preparation of a bovine intestinal low molecular weight heparin having the same structural properties and anti-factor IIa and anti-factor Xa activities of Enoxaparin. Moreover, this bovine intestinal heparin-derived “Enoxaparin” showed comparable platelet factor-4 binding affinity, suggesting that it should exhibit similarly low levels of heparin induced thrombocytopeneia, HIT.National Institutes of Healthhttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/acs.jmedchem.0c0201
Nanostructured glycan architecture is important in the inhibition of influenza A virus infection
No full textNature Nanotechnology, 12, 48-56Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.Rapid change and zoonotic transmission to humans have enhanced the virulence of the influenza A virus (IAV)3. Neutralizing antibodies fail to provide lasting protection from seasonal epidemics1,4. Furthermore, the effectiveness of anti-influenza neuraminidase inhibitors has declined because of drug resistance5. Drugs that can block viral attachment and cell entry independent of antigenic evolution or drug resistance might address these problems. We show that multivalent 6′-sialyllactose-polyamidoamine (6SL–PAMAM) conjugates, when designed to have well-defined ligand valencies and spacings, can effectively inhibit IAV infection. Generation 4 (G4) 6SL–PAMAM conjugates with a spacing of around 3 nm between 6SL ligands (S3–G4) showed the strongest binding to a hemagglutinin trimer (dissociation constant of 1.6 × 10−7 M) and afforded the best inhibition of H1N1 infection. S3–G4 conjugates were resistant to hydrolysis by H1N1 neuraminidase. These conjugates protected 75% of mice from a lethal challenge with H1N1 and prevented weight loss in infected animals. The structure-based design of multivalent nanomaterials, involving modulation of nanoscale backbone structures and number and spacing between ligands, resulted in optimal inhibition of IAV infection. This approach may be broadly applicable for designing effective and enduring therapeutic protection against human or avian influenza viruses.Ministry of Educationhttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1038/nnano.2016.18
Archi-texture: meditations on the mediations of dwelling
No full textThis thesis is an inter-disciplinary and inter- cultural exploration of home as understood as the place in which we usually live. Empirical research in an Australian suburb and an Indian town provide the fabric from which cultural studies engages with phenomenology to produce a design used to cut and style this exploration. Motivated by an interest in what threads contribute to the weave of contemporary household dwelling, this thesis revisits the two questions used by Heidegger to frame his essay 'Building Dwelling Thinking': What is it to dwell? and How does building belong to dwelling? It is an inquiry committed to its respondents as bearers and representatives of 'structures of feeling' circulating within the socio-cultural milieu or habitus in which they live and engage with the idea of 'home'. This inquiry offers an exploration of the chief constituent mediums of home which I call its 'archi-texture'. As such, it looks at location, physical and material attributes, domestic technology and household membership as framed by the presence or absence of a family. This thesis is almost certainly the only example of an empirically grounded examination of Heidegger?s ontological exposition of dwelling. Hence I position it as a meditation on the mediations of dwelling rather than a judgmental critique, although in no sense do I believe it to be either a dispassionate position nor an impartial digest of the research material
Human-water interface in hydrological modelling : Current status and future directions
No full textOver recent decades, the global population has been rapidly increasing and human activities have altered terrestrial water fluxes to an unprecedented extent. The phenomenal growth of the human footprint has significantly modified hydrological processes in various ways (e.g. irrigation, artificial dams, and water diversion) and at various scales (from a watershed to the globe). During the early 1990s, awareness of the potential for increased water scarcity led to the first detailed global water resource assessments. Shortly thereafter, in order to analyse the human perturbation on terrestrial water resources, the first generation of largescale hydrological models (LHMs) was produced. However, at this early stage few models considered the interaction between terrestrial water fluxes and human activities, including water use and reservoir regulation, and even fewer models distinguished water use from surface water and groundwater resources. Since the early 2000s, a growing number of LHMs have incorporated human impacts on the hydrological cycle, yet the representation of human activities in hydrological models remains challenging. In this paper we provide a synthesis of progress in the development and application of human impact modelling in LHMs. We highlight a number of key challenges and discuss possible improvements in order to better represent the human-water interface in hydrological models
In the Shadow of Night: Sleeping and Dreaming and Their Technical Rôles in Shakespearian Drama
No full textThis thesis aims to demonstrate the variety of ways in which sleep and dreams are employed in Shakespeare’s dramatic canon. Using a historical perspective, the work primarily examines the functions of these motifs within the design of the plays: how they contribute to the structure and unity of the works, how they assist in delineating some of the individual characters, and how they shape the atmosphere of specific dramatic situations. This kind of analysis requires an understanding of the cultural and intellectual contexts in which the fictitious representations of these phenomena were originally written and received. For this reason, the present thesis also offers a historical and cultural background, outlining the social character of the phenomena of sleep and dreams in early modern England and the history of their employment in pre-Shakespearian literature. Where relevant, the use of these motifs in the works of Shakespeare’s contemporaries is also studied.
The Introduction to the thesis summarizes the current state of knowledge of the topic and defines the present author’s approach to the research question. The first chapter discusses dream literature as a genre, its themes and development before Shakespeare’s time. The second chapter analyses the dramatic functions of a sleeping character on the stage in Shakespeare’s drama and how this image developed from the dramatist’s early plays to his later and more mature works. It examines how the motif affects the image of the character in question, but also how it influences the immediate dramatic context. A special section is devoted to the topos of dreams and its use as a characterization device. The third chapter deals with fictitious dream prophecies and their technical functions in Shakespeare’s plays. Again, the chapter follows the motif from the early stages of Shakespeare’s dramatic career to his last plays, trying to determine both its staple functions and changes in its employment. The last chapter addresses the dramatic image of the night as a time in which sleeping and dreaming – but also other typically dark enterprises – occur. A special section is devoted to Shakespeare’s use of the death-as-sleep metaphor and its dramatic implications
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