5,475 research outputs found
Toenails: An easily accessible and long-term stable source of DNA for genetic analyses in large-scale epidemiological studies [8]
No full textPG - 1168-70 AD - Department of Health Risk Analysis and Toxicology and. FAU - van Breda, Simone G AU - van Breda SG FAU - Hogervorst, Janneke G AU - Hogervorst JG FAU - Schouten, Leo J AU - Schouten LJ FAU - Knaapen, Ad M AU - Knaapen AM FAU - van Delft, Joost H AU - van Delft JH FAU - Goldbohm, R Alexandra AU - Goldbohm RA FAU - van Schooten, Frederik J AU - van Schooten FJ FAU - van den Brandt, Piet A AU - van den Brandt PA LA - eng PT - Journal Article PL - United States TA - Clin Chem JT - Clinical chemistry JID - 9421549 SB - I
Alcohol consumption and bladder cancer risk: results from The Netherlands Cohort Study.
No full textAm J Epidemiol 2001 Jan 1;153(1):38-41 Related Articles, Books, LinkOut Alcohol consumption and bladder cancer risk: results from The Netherlands Cohort Study. Zeegers MP, Volovics A, Dorant E, Goldbohm RA, van den Brandt PA. Department of Epidemiology, Maastricht University, The Netherlands. [email protected] Although several epidemiologic studies have been conducted on alcohol consumption and bladder cancer risk, the risk according to quantity and type of alcohol consumed is not clear. The authors investigated these associations in a large prospective cohort study on diet and cancer among 120,852 subjects in the Netherlands aged 55-69 years at baseline (1986). Subjects completed a questionnaire on risk factors for cancer, including alcohol consumption. Follow-up for incident cancer was established by record linkage to cancer registries. The case-cohort analysis was restricted to a follow-up period of 6.3 years and was based on 594 cases with bladder cancer and 3,170 subcohort members. The authors corrected for age and smoking in multivariable analyses. The incidence rate ratios for men who consumed or =30 grams of alcohol per day were 1.49, 1.52, 1.16, and 1.63 compared with nondrinkers, respectively (p for trend = 0.13). Alcohol consumed from beer, wine, and liquor was associated with moderately elevated risks, although most were not statistically significant. The incidence rate ratios for women varied around unity. The results of this study do not suggest an important association between alcohol consumption and bladder cancer risk
Am I shrinking? On clothing size and body size.
No full textComment on: Hughes LA, Schouten LJ, Goldbohm RA, van den Brandt PA, Weijenberg MP. Self-reported clothing size as a proxy measure for body size. Epidemiology. 2009 Sep;20(5):673-6. PMID: 1945182
Rayleigh number dependence of the Archimedes number dependent large-scale flow structure formation in mixed convection
No full textWe report on experimental investigations of large-scale flow structure formation in mixed convection. We characterize the flow field by measuring the velocity fields within a rectangular model room using 2D2C PIV. The control parameters are the Reynolds number Re, the Rayleigh number Ra and the Prandtl number Pr. All parameters are linked through the Archimedes number Ar. In 6.4x10-2 ≤ Ar ≤ 1.39x101, 4.2x103 ≤ Re ≤ 6.35x104 and Ra = 3.1x107, Ra = 1.8x108 and Pr = 0.713 we found flow 3 different flow structures. While keeping Ra and Pr constant and varying Ar through Re variations, we found an Ar dependence of the largescale flow structure formation within 6.4x10-2 ≤ Ar ≤ 1.39x101. Furthermore, we found a Ra dependence of the structure formation, which shifts the transition points between the structures to higher Archimedes numbers and reduces the mean velocities within the investigated domain
Dietary factors, genetic susceptibility and somatic mutations in colorectal cancer: a prospective study.
No full textItem does not contain fulltex
Toenail selenium levels and the risk of breast cancer
No full textToenail selenium levels and the risk of breast cancer. van den Brandt PA, Goldbohm RA, van't Veer P, Bode P, Dorant E, Hermus RJ, Sturmans F. Department of Epidemiology, University of Limburg, Maastricht, The Netherlands. The association between toenail selenium and breast cancer was studied in a prospective study on diet and cancer among 62,573 Dutch women aged 55-69 years that started in September 1986. The analysis was based on 355 breast cancer cases, detected during 3.3 years of follow-up (1986-1989), for whom selenium data were available. Selenium levels were significantly lower among cases diagnosed early during follow-up. After exclusion of cases that occurred in the first year of follow-up, multivariable-adjusted rate ratios of breast cancer in increasing quintiles of selenium were 1.00, 0.90, 0.76, 0.86, and 0.91 (trend p = 0.618). The authors found no evidence for an inverse association between selenium status and breast cance
Reynolds numbers near the ultimate state of turbulent Rayleigh-Bénard convection
No full textWe report on measurements of the mean-flow Reynolds number ReU and the rms fluctuation Reynolds number ReV in turbulent Rayleigh-Bénard convection as a function of the Rayleigh number Ra for 4 x 1011 < Ra < 2 1014 and Pr ' 0:8. Both can be described by the same power law with an effective exponent = 0:44, in agreement with predictions for ReU but in disagreement with predictions for ReV
Logarithmic variance profiles and the corresponding f-1 spectra of temperature fluctuations in turbulent Rayleigh-Bénard convection
No full textWe report experimental results for the temperature variance 2(z) and the corresponding frequency spectra P(f) in turbulent Rayleigh-Bénard convection (RBC) in a cylindrical sample of aspect ratioT= D/L = 1:00 (D = 1:12 m is the diameter and L = 1:12 m the height). The measurements were conducted in the Rayleigh-number range 1011 < Ra < 1:35 1014 and Pr ' 0:8. For Ra = 1:35x1014, 2(z) could be described well by a logarithmic dependence on the vertical position z in a range of z 1 < z < z 2 with z 1 ' 70 and z 2 = 0:1L. Here L=(2Nu) is the thickness of a thin thermal sublayer adjacent to the horizontal plate where the heat flux (denoted by the Nusselt number Nu) is carried mostly by thermal diffusion. In the log layer, we found that the temperature spectra had a significant frequency range over which P(f) f with close to 1. As Ra decreased, increased so that the log layer became thinner. At Ra = 2:05 1011, z 2 < z 1 and therefore there was no range for a log layer. Correspondingly, the temperature spectrum near the horizontal plate did not have the f1 scaling form either
Agreement between interview data and a self-administered questionnaire on dietary supplement use
No full textAgreement between interview data and a self-administered questionnaire on dietary supplement use. Dorant E, van den Brandt PA, Goldbohm RA, Hermus RJ, Sturmans F. Department of Epidemiology, University of Limburg, Maastricht. OBJECTIVE: To study the relative validity of an open-ended question on the consumption of dietary supplements in the preceding five-year period, incorporated in a self-administered questionnaire used in the NLCS, The Netherlands Cohort Study on diet and cancer (120,852 men and women aged 55-69 years). DESIGN: Questionnaire data were compared with reference information from three personal interviews carried out within a period of 10 months. SETTING AND SUBJECTS: A randomly selected subgroup (59 men and 50 women) of the cohort living in 12 municipalities in the eastern and western regions of The Netherlands. RESULTS AND CONCLUSIONS: The overall sensitivity of the questionnaire concerning the use of any dietary supplement was 65.9%, the specificity was 98.5%; kappa as measure of agreement was estimated at 0.69. A high percentage recall was observed among women, users of at least three types of dietary supplements, long-term supplement users and those in the oldest age group. Recall of intake of specific supplements ranged from 77.8% for garlic preparations to 11.8% for 'other' supplements. Estimates of consumption of specific supplements (garlic and vitamin preparations) may provide enough precision to correctly classify individuals as users or non-users of those supplement
A prospective study of dietary acrylamide intake and the risk of endometrial, ovarian, and breast cancer
No full textBACKGROUND: Acrylamide, a probable human carcinogen, was detected in various heat-treated carbohydrate-rich foods in 2002. The few epidemiologic studies done thus far have not shown a relationship with cancer. Our aim was to investigate the association between acrylamide intake and endometrial, ovarian, and breast cancer risk. METHODS: The Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55-69 years. At baseline (1986), a random subcohort of 2,589 women was selected using a case cohort analysis approach for analysis. The acrylamide intake of subcohort members and cases was assessed with a food frequency questionnaire and was based on chemical analysis of all relevant Dutch foods. Subgroup analyses were done for never-smokers to eliminate the influence of smoking; an important source of acrylamide. RESULTS: After 11.3 years of follow-up, 327, 300, and 1,835 cases of endometrial, ovarian, and breast cancer, respectively, were documented. Compared with the lowest quintile of acrylamide intake (mean intake, 8.9 mug/day), multivariable-adjusted hazard rate ratios (HR) for endometrial, ovarian, and breast cancer in the highest quintile (mean intake, 40.2 mug/day) were 1.29 [95% confidence interval (95% CI), 0.81-2.07; P(trend) = 0.18], 1.78 (95% CI, 1.10-2.88; P(trend) = 0.02), and 0.93 (95% CI, 0.73-1.19; P(trend) = 0.79), respectively. For never-smokers, the corresponding HRs were 1.99 (95% CI, 1.12-3.52; P(trend) = 0.03), 2.22 (95% CI, 1.20-4.08; P(trend) = 0.01), and 1.10 (95% CI, 0.80-1.52; P(trend) = 0.55). CONCLUSIONS: We observed increased risks of postmenopausal endometrial and ovarian cancer with increasing dietary acrylamide intake, particularly among never-smokers. Risk of breast cancer was not associated with acrylamide intake. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2304-13). AD - Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands. [email protected]. FAU - Hogervorst, Janneke G AU - Hogervorst JG FAU - Schouten, Leo J AU - Schouten LJ FAU - Konings, Erik J AU - Konings EJ FAU - Goldbohm, R Alexandra AU - Goldbohm RA FAU - van den Brandt, Piet A AU - van den Brandt PA LA - eng PT - Journal Article PL - United States TA - Cancer Epidemiol Biomarkers Prev JT - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncolog
- …
