1,568 research outputs found
Using growing RBF-nets in rubber industry process control
No full textThis paper describes the use of a Radial Basis Function (RBF) neural network in the approximation of process parameters for the extrusion of a rubber profile in tyre production. After introducing the rubber industry problem, the RBF network model and the RBF net learning algorithm are developed, which uses a growing number of RBF units to compensate the approximation error up to the desired error limit. Its performance is shown for simple analytic examples. Then the paper describes the modelling of the industrial problem. Simulations show good results, even when using only a few training samples. The paper is concluded by a discussion of possible systematic error influences, improvements and potential generalisation benefits. Keywords: Adaptive process control; Parameter estimation; RBF-nets; Rubber extrusio
Effect of sirolimus on malignancy and survival after kidney transplantation: systematic review and meta-analysis of individual patient data
No full textObjective To examine risk of malignancy and death in patients with kidney transplant who receive the immunosuppressive drug sirolimus.Design Systematic review and meta-analysis of individual patient data.Data sources Medline, Embase, and the Cochrane Central Register of Controlled Trials from inception to March 2013.Eligibility Randomized controlled trials comparing immunosuppressive regimens with and without sirolimus in recipients of kidney or combined pancreatic and renal transplant for which the author was willing to provide individual patient level data. Two reviewers independently screened titles/abstracts and full text reports of potentially eligible trials to identify studies for inclusion. All eligible trials reported data on malignancy or survival.Results the search yielded 2365 unique citations. Patient level data were available from 5876 patients from 21 randomized trials. Sirolimus was associated with a 40% reduction in the risk of malignancy (adjusted hazard ratio 0.60, 95% confidence interval 0.39 to 0.93) and a 56% reduction in the risk of non-melanoma skin cancer (0.44, 0.30 to 0.63) compared with controls. the most pronounced effect was seen in patients who converted to sirolimus from an established immunosuppressive regimen, resulting in a reduction in risk of malignancy (0.34, 0.28 to 0.41), non-melanoma skin cancer (0.32, 0.24 to 0.42), and other cancers (0.52, 0.38 to 0.69). Sirolimus was associated with an increased risk of death (1.43, 1.21 to 1.71) compared with controls.Conclusions Sirolimus was associated with a reduction in the risk of malignancy and non-melanoma skin cancer in transplant recipients. the benefit was most pronounced in patients who converted from an established immunosuppressive regimen to sirolimus. Given the risk of mortality, however, the use of this drug does not seem warranted for most patients with kidney transplant. Further research is needed to determine if different populations, such as those at high risk of cancer, might benefit from sirolimus.Ottawa Hosp, Res Inst, Ottawa, ON K1H 7W9, CanadaUniv Ottawa, Ottawa, ON, CanadaCairo Univ, Cairo Kidney Ctr, Cairo, EgyptLimites Med Res, Vacallo, SwitzerlandUniv Manitoba, Dept Pediat & Childs Hlth, Winnipeg, MB, CanadaLund Univ, Dept Nephrol & Transplantat, Malmo, SwedenUniversidade Federal de São Paulo, Hosp Rim & Hipertensao, São Paulo, BrazilAddenbrookes Hosp, Dept Renal Med, Cambridge, EnglandNorthwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USAMaastricht Univ, Med Ctr, Maastricht, NetherlandsSt Louis Hosp, Dept Nephrol, Paris, FranceHosp JW Goethe, Div Nephrol, Frankfurt, GermanyUniv Munich, Dept Surg, Munich, GermanyGoethe Univ Frankfurt, JW Goethe Clin, Clin Dermatol Venerol & Allergol, Frankfurt, GermanyInst Klin Expt Med, Dept Nephrol, Prague, Czech RepublicUniv Cambridge, Addenbrookes Hosp, Dept Surg, NIHR Cambridge Biomed Res Ctr, Cambridge CB2 2QQ, EnglandUniversidade Federal de São Paulo, Hosp Rim & Hipertensao, São Paulo, BrazilWeb of SciencePfize
Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages
No full textGenetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)-induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy. To determine whether vascular endothelial growth factor A (VEGF-A) produced by tumor-associated macrophages regulated the onset of the angiogenic switch, a genetic approach was used to restore expression of VEGF-A into tumors at the benign stages. This stimulated formation of a high-density vessel network and in macrophage-depleted mice, was followed by accelerated tumor progression. The expression of VEGF-A led to a massive infiltration into the tumor of leukocytes that were mostly macrophages. This study suggests that macrophage-produced VEGF regulates malignant progression through stimulating tumor angiogenesis, leukocytic infiltration and tumor cell invasion
Effect of Rolandic Spikes on ADHD Impulsive Behavior
No full textThe association of Rolandic spikes with the neuropsychological profile of children with attention deficit hyperactivity disorder (ADHD) was studied in a total of 48 patients at JW Goethe-University, Frankfurt/Main; and Central Institute of Mental Health, Mannheim, Germany
Fidelidad del cliente del Hotel JW Marriott el Convento Cusco -2020
No full textEl presente trabajo de investigación se titula “La fidelidad del cliente del hotel JW Marriott El
Convento Cusco-2020”. Teniendo en cuenta que la fidelidad del cliente es un tema que en la
hotelería es uno de los principales intereses y lo vienen desarrollando la mayoría de las cadenas
hoteleras más renombradas, como es Marriott Hotels y específicamente el hotel JW Marriott El
Convento Cusco. En el cual encontramos un problema del cual tratamos en la presente
investigación, la cual se basa en que: si el cliente no pasa satisfactoriamente las fases de
fidelización, no llega a fidelizarse completamente, ello se debe a que existen ciertos aspectos que
impiden una fidelización, es decir que pueden resquebrajar la fidelidad del cliente, por ejemplo los
inconvenientes que puede tener el cliente, ya sea previo al servicio (desde la reserva del servicio
por medio de Online Travel Agency o por otro medio), la entrega o disfrute del servicio (la estadía)
y el post servicio (después del check out del hotel). Por ello, la presente investigación tiene como
objetivo principal describir la fidelidad del cliente del hotel JW Marriott El Convento Cusco-2020.
Como también, los objetivos específicos que describen la fidelidad del cliente en cada una de las
fases de fidelización. La metodología manejada para la elaboración de la presente tesis fue de tipo
cuantitativo, el nivel es descriptivo no experimental.
Se obtuvo datos del autor (Oliver R. , 1999) sobre las fases de la fidelidad del cliente, que son
fidelidad cognitiva, fidelidad afectiva, fidelidad conativa y fidelidad de acción; las cuales se
utilizaron como dimensiones de la variable, describiendo cada una de ellas. Para describir la
fidelidad del cliente del hotel JW Marriott El Convento Cusco-2020 se realizó encuestas vía web
dada la coyuntura actual, con una muestra no probabilística de 102 personas que fueron los clientes
que voluntariamente respondieron el cuestionario.
Según los resultados obtenidos de las encuestas realizadas, se determinó que la fidelidad del cliente
del hotel JW Marriott El Convento Cusco-2020 es muy buena, al igual que sus cuatro fases de
fidelidad del cliente. Debido a que el hotel cumple con todas las expectativas que tiene el cliente y
al final genera una recompra por parte del cliente hacia el hotel JW Marriott El Convento Cusco,
dado por el cumplimiento de las cuatro fases de fidelización del cliente por lo siguiente: El cliente
es inicialmente fiel en un sentido cognitivo basado en la información y creencia que tiene el cliente,
después de las experiencias satisfactorias se genera un sentimiento de compromiso hacia el hotel
siendo fiel afectivamente, para así por medio de intenciones de comportamientos positivos por parte de asociados del hotel siendo fiel conativa, y finalmente el hotel al cumplir con todas las
expectativas del cliente y superar todos los obstáculos posibles se produce un control de la acción
que viene a ser la fidelidad de acción donde se produce la recompra del servicio del hotel JW
Marriott El Convento Cusco y retener al cliente.
Se pudo concluir que, el hotel JW Marriott El Convento Cusco es muy bueno fidelizando a sus
clientes y puede ser mejor incluso, si se siguen las propuestas planteadas. En la investigación, se
ha logrado describir cómo retener a los clientes y generar un compromiso profundo de recompra
del servicio JW Marriott El Convento Cusco por medio de las fases de fidelización.This research is titled “The costumer loyalty of the JW Marriott El Convento Cusco hotel-2020”.
We know that the loyalty in costumers is one of the most important issues for the hospitality
industry and it is been developed by most of the renowned hotel chains in the World, such as
Marriott Hotels and specifically the JW Marriott El Convento Cusco hotel. We found a problem
wich is based on the fact that: if the costumer doesn´t satisfactorily obtain the four loyalty phases,
the client will not become completely loyal to the hotel. This because there are some aspects that
don´t allow the loyalty, for example the pre service (from the reservation of the service through the
Online Travel agency or other method of reservation), the service (the stay) and the post service
(after the check out of the hotel). The main objective of this research is to describe the customer
loyalty of the JW Marriott El Convento Cusco hotel-2020. As well as, the especific objectives, that
describes the customer loyalty in each of the loyalty phases. The methodology used to prepare this
research was quantitative, and the level is descriptive, not experimental.
The data was obtained from the author (Oliver R. , 1999) that explained about the phases of
customer loyalty, which are Cognitive Loyalty, Afective loyalty, Conative loyalty and Action
loyalty; which were used as dimensions, describing each one of them. In order to describe the
costumer loyalty of the JW Marriott El Convento Cusco hotel-2020, we make the surveys via web
because of the current situation, with a non probability sample of 102 people who were the
costumers who voluntarily answered the questionnaire.
The costumer loyalty of the JW Marriott El Convento Cusco hotel -2020 was determined to be very
good, and also the phases of the customer loyalty as well. All that because the hotel meets all the
expectations that the customer has and in the end generates a repurchase by the customer from the
JW Marriott El Convento Cusco hotel, all that with the four phases of the loyalty of the client, and
we can detail that: The cliente initially gets the cognitive loyalty based in the information and
believes that the client has; after the satisfactory experiences, a feeling of commitment to the hotel
is generated, that is the afective loyalty; and for this reason through the intentions of positive
behaviors of the associates of the hotel, that is the conative loyalty; and finally when the hotel
meets all the expectations of the clients and overcoming all the possible obstacles, there is a control
of the action that comes to be the action loyalty, and the repurchase of the service of the JW Marriott
El Convento Cusco hotel occurs and retain more clients. In conclusion, the hotel JW Marriott El Convento Cusco is very good building customers loyalty
and can be better if the proposals proposed are followed. In the research, it has been possible to
describe how to retain customers and generate a deep commitment to repurchase the service of the
JW Marriott El Convento Cusco hotel through the loyalty phases
Persia
No full textLa Persia medievale diventa dopo la composizione del "Divano occidentale-orientale" di J.W. Goethe diventa un territorio mentale pensabile in tedesco. L'orientalismo che scaturisce dall'opera di Goethe, basata su una traduzione attenta alla differenza formale del ghazal persiano rispetto alla poesia tedesca, è una via alla crisi del classicismo, ma non una forma di esotismo, come invece accade nelle culture coloniali (inglese, tedesca).The medieval Persia becomes after the composition of JW Goethes " West-Eastern Divan " a mental territory for the German culture. Orientalism that stems from the work of Goethe, based on a translation of the Persian ghazal poetry that responds to the crisis of classicism, but not to a form of exoticism, as is the case in other more definitely colonial cultures (English, French)
The impact of neutralizer-free ignition of a radio frequency ion thruster on the lifetime of the ion optics system
No full textIn the initial stage of a radio frequency ion thruster (RIT) ignition, an influx of electrons is required from an external source into the discharge chamber and ionization of the neutral gas propellant. A neutralizer-free method for Townsend breakdown discharge ignition based on Paschen's law was developed in this study. The feasibility of the ignition method was confirmed by performing thousands of ignition experiments. Metallic Molybdenum (Mo), pyrolytic graphite (PG) and Zr41.2Ti13.8Cu12.5Ni10Be22.2 alloy acceleration grids were prepared, and ignition-induced damage on the grids was investigated. A field-emission scanning electron microscope was used to inspect surface damage on the grids after multiple ignitions and to analyze the influence of the ignition method on the lifetime of the ion optical system. Grid materials for space missions that require multiple RIT ignitions (10(3)) should be high-strength blocks that are resistant to sputtering corrosion and high temperature.</p
Cross listing and firm value - corporate governance or market segmentation? An empirical study of the stock market
No full textThis study investigates the economic consequences of cross-listing on the Chinese stock market. We argue that by adopting a higher disclosure standard through cross- listing firms voluntarily commit themselves to reducing information asymmetry. As a result, cross-listed firms are able to benefit from growth opportunities with less appropriated cash flow and lower cost of capital. The empirical evidence shows that cross-listed firms indeed command higher valuations than their non-cross-listed counterparts, after controlling for certain firm-specific attributes. This lends support to the corporate governance hypothesis of cross-listing on the Chinese stock market. The study also argues that an overall upgrad-ing of accounting standards cannot substitute for the cross-listing mechanism.corporate governance; listing; China
Role of BMP3 in progression of gastric carcinoma in Chinese people
No full textAuthor contributions: Chen XR designed the study and wrote the manuscript; Wang JW performed the majority of experiments; Li X and Wang JW provided the vital reagents and analytical tools and were also involved in editing the manuscript; Zhang H and Ye ZY coordinated and provided the collection of all human materials in addition to financial support for this work
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